IndraLab

Statements

USP48 ubiquitinates TP53. 3 / 3
| 3
sparser
"USP48 can enhance Mdm2-mediated p53 ubiquitination and degradation."
28233861
sparser
"Importantly, p53 degradation assay showed that the USP48-induced increase in Mdm2-mediated p53 ubiquitination could also lead to more efficient p53 degradation ( xref )."
28233861
sparser
"While the co-expression of Mdm2 and USP48 strongly enhanced p53 ubiquitination ( xref ), USP48 was not capable of inducing p53 ubiquitination in the absence of Mdm2 ( xref ), suggesting that the observed increase in Mdm2 levels was largely responsible for the enhancement of p53 ubiquitination in the presence of USP48."
28233861