IndraLab

Statements

USP48 ubiquitinates TP53. 3 / 3
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"While the co-expression of Mdm2 and USP48 strongly enhanced p53 ubiquitination ( xref ), USP48 was not capable of inducing p53 ubiquitination in the absence of Mdm2 ( xref ), suggesting that the observed increase in Mdm2 levels was largely responsible for the enhancement of p53 ubiquitination in the presence of USP48."
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"Importantly, p53 degradation assay showed that the USP48-induced increase in Mdm2-mediated p53 ubiquitination could also lead to more efficient p53 degradation ( xref )."
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"USP48 can enhance Mdm2-mediated p53 ubiquitination and degradation."
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