IndraLab

Statements

USP48 activates CRH. 4 / 4
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"USP48 pathogenic variants are relatively frequent in USP8 wild-type tumors and enhance CRH-induced hormone production in a manner coherent with sonic hedgehog activation."
31222332
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"The USP48 variant identified potentiated the stimulatory action of hypothalamic corticotropin-releasing hormone (CRH) on ACTH synthesis in a GLI1-dependent manner."
31845722
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"Overexpression of USP48 wt potentiated the stimulatory CRH action (173% ± 13% for ACTH secretion and 171% ± 15% for POMC promoter activity vs CRH treated mock transfected controls, P < 0.01; representative example in Fig. 3D and E)."
31222332
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"Based on initial evidence in the literature, USP48 and USP8 mutations in PitNETs are believed to enhance corticotropin releasing hormone (CRH)-induced production coherent with the Hh signaling pathway (Fig 3E)."
36640905