IndraLab

Statements

USP48 binds GLI1. 7 / 7
| 1 6
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"The deubiquitinase USP48 is able to interact directly with GLI1, cleaving off its ubiquitin and thus enhancing its lifetime. xref In GBM cells, knockdown of USP48 inhibits cell proliferation and expression of GLI1’s downstream targets, leading to repressed tumorigenesis."
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"Zhou and colleagues sustained a positive feedback loop by which HH signaling activates USP48 through the binding of GLI1 to Usp48 promoter."
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"Mechanistically, USP48 interacts with Gli1 and cleaves its ubiquitin off directly."
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"USP48 interacts with Gli1 through its C-terminal DUSP domain to remove ubiquitin moiety from Gli1."
| PMC
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"In human glioblastoma, USP48 and Gli1 expression levels were positively correlated, and high USP48 expression levels correlated with higher grades of glioma malignancy [ xref ], suggesting that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis."
| PMC
sparser
"This evidence underlies the relevance of USP48-GLI1 regulatory axis for glioma cell proliferation and glioblastoma tumorigenesis [ xref ]."
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"Depletion of USP48 inhibits glioma cell viability and tumor generation by partially stabilizing Gli1, which incidates a critical role of the USP48‐Gli1 axis in glioblastoma tumorigenesis ( xref ) ( xref )."
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