IndraLab

Statements

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"By contrast, USP48 depletion did not enhance MMC induced RAD51 focus formation in control cells, suggesting that USP48 may inhibit HR processes specifically in an FA deficient background."
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"Together, the findings indicate that USP48 antagonizes BRCA1/BARD1 Ub ligase-dependent activities in HR, creating a balance that regulates DNA end-resection tract length [78, 80] (Figure 5B)."
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"As we had found that USP48 loss enhances HR in DeltaFANCC cells, we determined whether it could also alleviate chromosome breaks in DeltaFANCC cells."
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"At 18h after MMC treatment, recruitment of RAD51 into foci was significantly higher in U2OS cells simultaneously depleted for both FANCC and USP48 by siRNA treatment, compared to cells depleted for FANCC alone, implying that USP48 loss restores HR efficiency at replication forks encountering ICL damage in FA deficient cells."
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