IndraLab

Statements

USP48 binds MDM2. 3 / 3
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"More detailed subsequent analyses of Mdm2-USP48 interactions suggested the presence of two independent USP48-binding sites in Mdm2 ( xref , xref )."
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"To test the possible effect of USP48-Mdm2 interactions on Mdm2 protein stability, Mdm2 was expressed in U2OS cells together with increasing amounts of USP48."
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"One possible explanation could be provided by our finding that USP48 binds to the central acidic domain of Mdm2, a region that was shown by us and others to independently contribute to p53 ubiquitination and to p53 and Mdm2 stability xref xref xref xref xref ."
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