IndraLab

Statements

USP48 inhibits E3_Ub_ligase. 3 / 3
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"In cells we reveal that USP48 antagonizes BRCA1 E3 ligase function and in BRCA1-proficient cells loss of USP48 results in positioning 53BP1 further from the break site and in extended resection lengths."
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"For instance, USP48 might bind UNC119a and block the recognition site of the E3 ligase, preventing UNC119a from being ubiquitinated and targeted for proteasomal degradation."
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"Further, USP48 promotes cell survival and antagonizes also other E3 ligase functions which are involved in genome stability and DNA repair."
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