IndraLab

Statements

USP48 activates Neoplasms. 5 / 5
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"Finally, overexpression of USP48 enhanced the therapeutic efficacy of PD-1 inhibitors in tumors in mouse models."
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"Consequently, we proceeded to investigate the function of USP48 in promoting CRC metastasis in vivo.Our findings consistently demonstrate that knockdown of USP48 in CRC cells significantly suppresses tumor metastasis compared to control cells in liver and lung metastasis models of CRC."
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"It is therefore of interest to show that somatic activating pathogenic variants in the USP48 gene may induce corticotroph tumorigenesis by enhancing corticotroph tumor response to hypothalamic CRH stimulation.Among the potential USP48 substrates, Gli1 is of particular interest for corticotroph pathophysiology."
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"Collectively, these findings suggest that USP48 enhances tumor metastasis largely by regulating HMGA2 in vitro and in vivo.3."
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"Subsequent research revealed that USP48 promotes tumor progression, metastasis, and chemoresistance by inhibiting the degradation of cancer-related proteins such as MDM2, RelA, Gli1, Aurora B, and HMGA2."
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