IndraLab

Statements


USP48 activates RELA. 4 / 4
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"USP48 Overexpression Promotes p65 Nuclear Localization."

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"Interestingly, overexpressed USP48 promoted RelA nuclear accumulation 30 min after TNF stimulation independent of catalytic site Cys C98."

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"Another study on USP48-mediated p65/p50 regulation conducted in retinal pigment epithelial cells unveils that knockdown of USP48 causes destabilization of both cytoplasmic and nuclear p65 and downregulates NF-κB activity despite the interaction between USP48 and p65 (59)."

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"USP48 Downregulation Induces Basal p65 Stabilization."