IndraLab

Statements

GPS1 binds USP48. 2 / 4
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"While, in human cells, USP15 specifically binds to CSN7A [ xref ] and consequently to the CSN CSN7A-USP15 -CRL3 BTB complex [ xref ], USP48 is associated with CSN1 [ xref ] but interacts mostly with CSN CSN7B-USP48 -CRL4A/B [ xref ]."
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"We found that deubiquitinylase (DUB) ubiquitin specific protease 48 (USP48), which interacts with the COP9 signalosome (CSN) subunit CSN1, stabilises RelA by deubiquitinylation and thereby promotes the transcriptional activity of RelA to prolong de novo synthesis of DUB A20 in H. pylori infection."
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