IndraLab

Statements

reach
"Intriguingly, GLI1 is the downstream target of sonic hedgehog (SHH) signaling that is deregulated in corticotroph tumors [57] indicating that both USP8 and USP48 might trigger corticotroph tumorigenesis via the same pathway."
31845722
reach
"It is therefore of interest to show that somatic activating pathogenic variants in the USP48 gene may induce corticotroph tumorigenesis by enhancing corticotroph tumor response to hypothalamic CRH stimulation.Among the potential USP48 substrates, Gli1 is of particular interest for corticotroph pathophysiology."
31222332
reach
"Additionally, USP48 has been shown to promote tumorigenesis by stabilizing oncoproteins such as Gli1, TRAF2, and Mdm2."
39878157