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USP48 activates NFkappaB. 3 / 3
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"For example, USP6/TRE17 is involved in activation of NF-κB pathway [ 24 , 25 ]; USP8 regulates T cell homeostasis and mitophagy in mitochondria [ 26 , 27 ]; USP10 or USP42 regulates p53 localization a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, subsequent studies demonstrated that in fact USP48 promotes NF-kappaB activity by co-operating with the COP9 signalosome to trim K48 linked polyubiquitin chains from p65 in the nucleus [XREF_BIBR]."
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"The inhibition of NF-κB activation by USP31 was not due to a reduction of effector protein expression, since Western blot analysis revealed that the levels of all effector proteins were unaffected by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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