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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP48 activates SLC9A3. 2 / 2

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"USP48 silencing decreased NHE3 's half-life (USP48 siRNA t1/2 = 6.1 h vs. vehicle t1/2 = 12.9 h), whereas overexpression of USP48 increased NHE3 half-life (t1/2 = 21.8 h), indicating that USP48 protects NHE3 from degradation via deubiquitinylation."

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"That is, the dopamine D3 receptor inhibits USP48 expression, which promotes NHE3 degradation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...