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USP48 activates SLC9A3. 2 / 2

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"USP48 silencing decreased NHE3 's half-life (USP48 siRNA t1/2 = 6.1 h vs. vehicle t1/2 = 12.9 h), whereas overexpression of USP48 increased NHE3 half-life (t1/2 = 21.8 h), indicating that USP48 protects NHE3 from degradation via deubiquitinylation."

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"That is, the dopamine D3 receptor inhibits USP48 expression, which promotes NHE3 degradation."

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USP48 activates SLC9A3. 2 / 2

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