IndraLab

Statements

USP48 activates cell population proliferation. 5 / 5
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"In vivo and in vitro functional investigations have demonstrated that overexpression of USP48 promotes the proliferation of CRC cells."
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"XREF_BIBR In GBM cells, knockdown of USP48 inhibits cell proliferation and expression of GLI1 's downstream targets, leading to repressed tumorigenesis."
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"MTT experiments showed that both HHT and USP48 shRNA could inhibit AML cell proliferation, and inhibiting USP48 could enhance the effect of HHT (Figure 6b)."
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"Suppression of USP48 inhibits proliferation and promotes tumor cell death, making it a potential target for cancer therapy.PR-619, a broad DUB inhibitor that includes USP48, is considered a promising anti-cancer drug."
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"Furthermore, inhibition of USP48 expression through shRNA knockdown in AML cell lines significantly reduced cell proliferation, promoted apoptosis, and induced G1 phase arrest."
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