IndraLab

Statements

USP48 is phosphorylated. 9 / 9
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"Exposure to TNFα caused GSK3β-mediated phosphorylation of USP48, leading to deubiquitination of TRAF2 in beas2B cells, increasing JNK signaling upon TNF-α-induction [ xref ]."
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"In response to TNF however, phosphorylation of USP48 is transient ( Fig. 8 C)."
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"Exposure to TNFα caused GSK3β-mediated phosphorylation of USP48, leading to deubiquitination of TRAF2 in beas2B cells, increasing JNK signaling upon TNF-α-induction [71]."
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"Interestingly, association of CK2 with the CSN and CK2-mediated phosphorylation of its subunits CSN2 and CSN7 have been observed [46] , implying potential reciprocal regulation of CK2 and CSN activit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We show that USP48 trims rather than completely disassembles long K48-linked free and substrate-anchored Ub-chains, a catalytic property only shared with ataxin-3 (Atx3) and otubain-1 (OTU1), and that USP48 Ub-chain-trimming activity is regulated by casein-kinase-2 (CK2)-mediated phosphorylation in response to cytokine-stimulation."
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"The ability of CK2 to phosphorylate USP48 at C-terminal sites was confirmed in kinase assays with recombinant USP48 variants, tagged at the N-term with GST ( Fig. 6 A )."
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"When USP48-FL was subjected to an in vitro kinase assay prior to and during the labeling reaction, labeling was suppressed indicating that phosphorylation of USP48 in the C-term changes its catalytic [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast to HA-Ub-VS-labeling of USP48, which was (transiently) lost after TNF stimulation and upon CK2-mediated phosphorylation ( Fig. 7 A), phosphorylation of USP48 in response to 2 h TNF stimula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP48 phosphorylation at its C-terminal CK2 phosphorylation sites in response to TNF was confirmed after knockdown of endogenous USP48, followed by reexpression of either siRNA-resistant USP48-FL WT [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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