IndraLab

Statements

USP48 binds RELA. 15 / 15
5 | 6 4
reach
"We found that USP48 cleaved poly-Ub-chains bound to RelA."
35913642
biogrid
No evidence text available
30628021
reach
"Another study on USP48-mediated p65/p50 regulation conducted in retinal pigment epithelial cells unveils that knockdown of USP48 causes destabilization of both cytoplasmic and nuclear p65 and downregulates NF-κB activity despite the interaction between USP48 and p65 (59)."
39507445
biogrid
No evidence text available
30628021
biogrid
No evidence text available
30628021
sparser
"A candidate target of USP31 could be p65/RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."
16214042
sparser
"Initial studies found that overexpression of USP48 inhibits NF-κB activity downstream of IKKβ and that USP48 also interacts with p65."
27187478
reach
"It is however possible, that TNF induced ubiquitination of RelA and/or other yet to be identified inducible PTMs of RelA, USP48 or unknown interaction partners are required to mediate this interaction[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
reach
"Although colocalization does not imply an interaction between proteins, previous data described a direct interaction between USP48 and p65."
36077078
reach
"USP48 interacts with the transcription factor NF-kappaB, deubiquitinates NF-kappaB subunit p65 and promotes its stability and activation, and up-regulates NF-kappaB target genes known to inhibit synaptogenesis."
37781625
biogrid
No evidence text available
33903120
reach
"Initial studies found that overexpression of USP48 inhibits NF-kappaB activity downstream of IKKbeta and that USP48 also interacts with p65."
27187478
biogrid
No evidence text available
36607699
sparser
"The association of USP48 with RelA is likely strengthened upon RelA ubiquitination."
25486460
sparser
"In this study we report that USP48 interacts physically with RelA in the nucleus."
30628021