IndraLab

Statements

Hedgehog increases the amount of USP48. 4 / 4
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"Additionally, active HH signaling induces USP48 expression via a positive feedback loop by GLI1 binding to the USP48 promoter (203)."
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"In addition, we find that the Sonic Hedgehog (SHH) pathway induces USP48 expression through Gli1 mediated transcriptional activation, which forms thus a positive feedback loop to regulate Hh signaling."
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"USP48 provides a positive feedback loop in Hh signaling as USP48 expression is induced by Hh activation."
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"In addition, to a certain extent, GLI1 determines the effect of USP48 on cell proliferation and tumorigenesis and the HH pathway also induces USP48 expression via GLI1 trans-activation, thus forming a mutual feedback loop (73)."
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