IndraLab

Statements

USP48 activates Cell Survival. 5 / 5
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"USP48 is implicated in activation of NF-κB (Mirra et al. 2022; Schweitzer and Naumann 2015; Ghanem et al. 2019), induces pyroptosis by stabilization of Gasdermin E (Ren et al. 2023) and promotes cell survival in Helicobacter pylori infection (Jantaree et al. 2022)."
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"Together, USP48 and A20 promoted GC cell survival during H. pylori infection and suggested an oncogenic role for A20."
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"USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection."
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"Furthermore, USP48 promotes cell survival during H. pylori infection through A20-dependent suppression of caspases activity and apoptotic cell death."
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"Further, USP48 promotes cell survival and antagonizes also other E3 ligase functions which are involved in genome stability and DNA repair."
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