IndraLab

Statements

USP33 affects ROBO1
1 3 1 | 29 19
USP33 binds ROBO1.
3 | 11 19
ROBO1 binds USP33. 10 / 32
3 | 11 15
biogrid
No evidence text available
19684588
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"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"In lung cancer cells, USP33 interacted with Robo1, similar to the observation in the breast cancer cells, as detected by co-immunoprecipitation experiments (Fig.  xref A)."
24981056
sparser
"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells xref , xref ."
25242263
sparser
"The mechanism of the interaction between Robo1 and USP33 was explored by co-IP and ubiquitination protein analysis."
30896071
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"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells XREF_BIBR, XREF_BIBR."
25242263
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"USP33 interacts with Robo1 and mediates Slit2 signaling in CRC cells."
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"USP33 interacts with the axonal guidance receptor Roundabout (Robo) 1 [ xref ], whose ligand is Slit."
21704388
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"The mechanism of the interaction between Robo1 and USP33 was explored by co-IP and ubiquitination protein analysis."
30896071
biogrid
No evidence text available
19706539
ROBO1 binds USP33 and CRC. 2 / 2
| 2
sparser
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
25242263
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
ROBO1 binds HTATIP2 and USP33. 1 / 1
| 1
sparser
"Co-immunoprecipitation using deletion mutants of Robo1 and USP33 showed that the Robo1 CC3 motif interacted with USP33 in the region containing the catalytic USP and substrate-recognizing DUSP domains xref ( xref )."
19684588
USP33 deubiquitinates ROBO1.
1 1 | 7
USP33 deubiquitinates ROBO1. 7 / 7
1 | 6
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"USP33 mediates Slit2 signaling by deubiquitinating and stabilizing Robo1."
25242263
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"USP33 deubiquitinates ROBO1 in lung cancer cells to maintain its stability, thereby regulating SLIT2 activity and inhibiting cancer cell metastasis [XREF_BIBR]."
29743814
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"Cell based assays support a model in which USP33 reverses Robo1 ubiquitination : knockdown of USP33 increases levels of ubiquitinated Robo1, while USP33 overexpression reduces ubiquitinated Robo1 levels [XREF_BIBR]."
21704388
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"These results show that USP33 mediates Slit-Robo signaling by deubiquitinating and stabilizing Robo1 in CRC cells (XREF_SUPPLEMENTARY)."
25242263
ubibrowser
"Robo-interacting ubiquitin-specific protease 33 (USP33) is required for the inhibitory function of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
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"USP33 deubiquitinates and stabilizes Robo1."
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"Though direct deubiquitination of Robo1 by USP33 has not been reported, it is reasonable to speculate that USP33 deubiquitinates and thus rescues Robo1 from degradation during the Slit response."
21704388
Modified USP33 leads to the deubiquitination of ROBO1. 1 / 1
| 1
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"Overexpression of wild-type USP33, but not catalytically inactive C163A mutant of USP33, decreased the ubiquitination of Robo1."
24981056
USP33 deubiquitinates ROBO1 on lysine. 1 / 1
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biopax:reactome
No evidence text available
USP33 increases the amount of ROBO1.
| 4
USP33 increases the amount of ROBO1. 2 / 2
| 2
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"Knocking-down USP33 in H1299 cells increased the level of ubiquitinylated Robo1 in the presence of MG132, an inhibitor of the ubiquitin proteasome system."
24981056
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"USP33 silencing in A549 and SPC-A-1 cells significantly promoted the cell migration, invasion and metastasis and obviously down-regulated the expressions of SLIT2 and ROBO1."
30187867
Modified USP33 increases the amount of ubiquitinated ROBO1. 1 / 1
| 1
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"USP33 knockdown increased the ubiquitinated Robo1 level, whereas overexpression of GFP-USP33 reduced the ubiquitinated Robo1 level (XREF_SUPPLEMENTARY), suggesting that USP33 play a role in Robo1 deubiquitination."
19684588
Modified USP33 increases the amount of ROBO1. 1 / 1
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"Conversely, overexpression of wild-type USP33, not the C163A mutant USP33, in H1299 cells increased the levels of Robo1."
24981056
USP33 inhibits ROBO1.
| 2
USP33 inhibits ROBO1. 2 / 3
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"Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells."
24981056
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"Similarly, the downregulation of USP33 (a ubiquitin ligase enzyme) reduces the stability of the ROBO1 receptor in lung cancer cells 29 and breast cancer cell migration 30."
33318575
USP33 decreases the amount of ROBO1.
| 3
USP33 decreases the amount of ubiquitinated ROBO1. 2 / 2
| 2
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"Cell based assays support a model in which USP33 reverses Robo1 ubiquitination : knockdown of USP33 increases levels of ubiquitinated Robo1, while USP33 overexpression reduces ubiquitinated Robo1 levels [XREF_BIBR]."
21704388
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"USP33 knockdown increased the ubiquitinated Robo1 level, whereas overexpression of GFP-USP33 reduced the ubiquitinated Robo1 level (XREF_SUPPLEMENTARY), suggesting that USP33 play a role in Robo1 deubiquitination."
19684588
USP33 decreases the amount of ROBO1. 1 / 1
| 1
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"Overexpression of USP33 reduced, whereas knocking-down USP33 increased the level of ubiquitinylated Robo1 (XREF_FIG)."
25242263
USP33 activates ROBO1.
| 1
USP33 activates ROBO1. 1 / 2
| 1
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"Though direct deubiquitination of Robo1 by USP33 has not been reported, it is reasonable to speculate that USP33 deubiquitinates and thus rescues Robo1 from degradation during the Slit response."
21704388
USP33 ubiquitinates ROBO1.
| 1
USP33 leads to the ubiquitination of ROBO1. 1 / 1
| 1
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"USP33 mediates the inhibitory function of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
BTRC affects USP33
| 24 12
BTRC binds USP33.
| 5 11
BTRC binds USP33. 10 / 14
| 5 9
sparser
"We found that USP33(△DSG) can also interact with β-TrCP ( Fig. 3 B )."
28506875
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"We found that USP33 (^ DSG) can also interact with beta-TrCP."
28506875
sparser
"Furthermore, we found that the WD40 motif of β-TrCP and 201-400 amino acid motif of USP33 are required for the interaction between β-TrCP and USP33."
28506875
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"Beta-TrCP can also interact with FH-USP33 (^ DSG), indicating that the interaction between beta-TrCP and USP33 is independent of DSG motif of USP33."
28506875
sparser
"Our data showed that USP33 was able to interact with β-TrCP-WT, but unable to interact with β-TrCP-△WD40 ( Fig. 3 D )."
28506875
sparser
"Collectively, we found that the WD40 motif of β-TrCP and 201–400 amino acid motif of USP33 are necessary for the interaction between β-TrCP and USP33."
28506875
sparser
"Β-TrCP is able to interact with USP33, and promotes the ubiquitination and proteasomal degradation of USP33."
28506875
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"These results suggest that the effect of beta-TrCP on USP33 is independent of the classic DSG motif.Since beta-TrCP promotes USP33 ubiquitin dependent degradation, then we assessed the interaction bet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
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"The interaction of β-TrCP with these USP33 mutants was evaluated."
28506875
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"We also revealed that beta-TrCP interacted with USP33 independently of the classic binding motif for beta-TrCP, and mediated USP33 degradation via the ubiquitin proteasome pathway."
28506875
BTRC binds USP33 and infC. 1 / 1
| 1
sparser
"Therefore, USP33 isoform 3 is suitable for the analysis of interaction between β-TrCP and USP33-DSG motif."
28506875
BTRC binds USP33 and FH. 1 / 1
| 1
sparser
"Β-TrCP can also interact with FH-USP33(△DSG) ( Fig. 3 B ), indicating that the interaction between β-TrCP and USP33 is independent of DSG motif of USP33."
28506875
BTRC activates USP33.
| 9
BTRC activates USP33. 9 / 9
| 9
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"Consequently, beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and cell invasion."
28506875
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"These results indicate that beta-TrCP attenuates USP33 mediated inhibition of cell proliferation."
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"Taken together, these results suggest that beta-TrCP downregulates USP33 expression at the protein level but not at the mRNA level.To uncover the mechanism of USP33 downregulation mediated by beta-TrC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
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"Our results showed that MG132 blocked beta-TrCP-mediated USP33 downregulation, suggesting that beta-TrCP promotes USP33 downregulation via the proteasome pathway."
28506875
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"Furthermore, we demonstrated that overexpression of beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and invasion."
28506875
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"Furthermore, we found that beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and cell invasion."
28506875
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"Taken together, we found that beta-TrCP attenuates USP33 mediated inhibition of cell proliferation and invasion.So far, the study of USP33 is still very limited."
28506875
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"The results showed that knockdown of beta-TrCP in cells slowed down the degradation rate of endogenous USP33 and therefore enhanced USP33 protein stability."
28506875
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"These data suggest that beta-TrCP might mediate USP33 downregulation at the protein level."
28506875
BTRC decreases the amount of USP33.
| 3
BTRC decreases the amount of USP33. 3 / 4
| 3
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"In contrast, knockdown of beta-TrCP in HEK293T cells upregulated endogenous USP33 protein levels."
28506875
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"Taken together, these results suggest that beta-TrCP downregulates USP33 expression at the protein level but not at the mRNA level.To uncover the mechanism of USP33 downregulation mediated by beta-TrC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
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"Here, we found that beta-TrCP downregulated cellular levels of endogenous USP33."
28506875
BTRC ubiquitinates USP33.
| 2 1
BTRC leads to the ubiquitination of USP33. 2 / 2
| 1 1
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"Furthermore, beta-TrCP also increased the ubiquitination of USP33 (^ DSG) and decreased the protein stability of USP33 (^ DSG)."
28506875
sparser
"Furthermore, β-TrCP also increased the ubiquitination of USP33(△DSG) ( Fig. 2 D ) and decreased the protein stability of USP33(△DSG) ( Fig. 4 B )."
28506875
Modified BTRC leads to the ubiquitination of USP33. 1 / 1
| 1
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"The results showed that overexpression of beta-TrCP substantially increased the poly-ubiquitination of endogenous USP33."
28506875
BTRC inhibits USP33.
| 3
BTRC inhibits USP33. 3 / 3
| 3
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"Deubiquitinase USP33 is negatively regulated by beta-TrCP through ubiquitin dependent proteolysis."
28506875
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"Thus, our data revealed a new regulatory mechanism of the deubiquitinase USP33, and uncovered an additional signaling pathway, that is, beta-TrCP downregulates USP33 to promote cell proliferation.HeLa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
reach
"The results showed that knockdown of beta-TrCP in cells slowed down the degradation rate of endogenous USP33 and therefore enhanced USP33 protein stability."
28506875
BTRC increases the amount of USP33.
| 2
BTRC increases the amount of USP33. 1 / 1
| 1
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"Conversely, knockdown of beta-TrCP significantly decreased the ubiquitination levels of endogenous USP33."
28506875
Modified BTRC increases the amount of USP33. 1 / 1
| 1
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"We found that overexpression of beta-TrCP did not decrease, but slightly increased USP33 mRNA levels."
28506875
ROBO1 affects USP33
3 | 11 19
ROBO1 binds USP33. 10 / 32
3 | 11 15
biogrid
No evidence text available
19684588
reach
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"In lung cancer cells, USP33 interacted with Robo1, similar to the observation in the breast cancer cells, as detected by co-immunoprecipitation experiments (Fig.  xref A)."
24981056
sparser
"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells xref , xref ."
25242263
sparser
"The mechanism of the interaction between Robo1 and USP33 was explored by co-IP and ubiquitination protein analysis."
30896071
reach
"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells XREF_BIBR, XREF_BIBR."
25242263
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"USP33 interacts with Robo1 and mediates Slit2 signaling in CRC cells."
25242263
sparser
"USP33 interacts with the axonal guidance receptor Roundabout (Robo) 1 [ xref ], whose ligand is Slit."
21704388
reach
"The mechanism of the interaction between Robo1 and USP33 was explored by co-IP and ubiquitination protein analysis."
30896071
biogrid
No evidence text available
19706539
ROBO1 binds USP33 and CRC. 2 / 2
| 2
sparser
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
25242263
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
ROBO1 binds HTATIP2 and USP33. 1 / 1
| 1
sparser
"Co-immunoprecipitation using deletion mutants of Robo1 and USP33 showed that the Robo1 CC3 motif interacted with USP33 in the region containing the catalytic USP and substrate-recognizing DUSP domains xref ( xref )."
19684588
USP33 affects ARRB2
9 1 | 15 9
USP33 binds ARRB2.
9 | 4 9
USP33 binds ARRB2. 10 / 22
9 | 4 8
sparser
"These conformation-specific interactions are supported by observations from two sets of assays conducted in vitro: (1) interaction of purified β-arrestin2 and USP33 is augmented by addition of a synth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23764054
biogrid
No evidence text available
19363159
sparser
"While examining the kinetics of agonist-dependent association of endogenously expressed USP33 with β-arrestin2, characteristic binding patterns were revealed ()."
24377933
biogrid
No evidence text available
19363159
sparser
"Upon β 2 AR activation, the recruited β-arrestins are rapidly ubiquitinated and deubiquitinated, and this is facilitated by a high-affinity interaction between β-arrestin2 and USP33."
21680031
biogrid
No evidence text available
19363159
reach
"Upon beta 2 AR activation, the recruited beta-arrestins are rapidly ubiquitinated and deubiquitinated, and this is facilitated by a high-affinity interaction between beta-arrestin2 and USP33."
21680031
sparser
"Upon stimulation of the βAR with isoproterenol, a robust increase in the association of β-arrestin2 and USP33 was detected."
24377933
biogrid
No evidence text available
19363159
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
USP33 binds AR and ARRB2. 1 / 1
| 1
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
USP33 deubiquitinates ARRB2.
1 | 6
USP33 deubiquitinates ARRB2. 7 / 7
1 | 6
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"Subsequent deubiquitination of beta-arrestin 2 by the deubiquitinase USP33 dissociates the receptor, beta, and arrestin complex."
19853559
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"USP33 leads to de-ubiquitination of beta-arrestin2 with non degradative effects."
27835898
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"Further results verified that USP33 can deubiquitinate beta-arrestin2, subsequently block the internalization of SDF-1-stimulated CXCR4, and disrupt beta-arrestin-dependent ERK activation."
27835898
ubibrowser
No evidence text available
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"Beta-arrestin-2 can be ubiquitinated by Mdm2 (see above) and deubiquitinated by the DUB enzyme USP33."
20854416
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"Importantly, a knockdown of USP20 and USP33 enhances beta-arrestin2 ubiquitination and increases beta 2 AR degradation [XREF_BIBR, XREF_BIBR]."
24680432
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"Given that the enzymatic activity of USP33 is important in regulating CXCR4 internalization, we were interested in whether USP33 can deubiquitinate beta-arrestin2 and subsequently regulate CXCR4 endocytosis."
27835898
USP33 ubiquitinates ARRB2.
| 2
USP33 leads to the ubiquitination of ARRB2. 2 / 2
| 2
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"Depletion of USP33 completely inhibited the deubiquitination of beta-arrestin2 observed after stimulating the beta 2 AR for 10 min."
24377933
reach
"Importantly, a double knockdown of USP20 and USP33 enhances the extent of beta-arrestin-2 ubiquitination and increases beta 2 AR degradation."
24292830
USP33 decreases the amount of ARRB2.
| 2
USP33 decreases the amount of ARRB2. 2 / 2
| 2
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"Further experiments revealed that USP33 silencing, which increased the ubiquitination level of beta-arrestin2, can lead to non degradative effects towards this scaffold protein, but augment the endocytosis of ligand binding CXCR4."
27835898
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"The IHC results also indicated that USP33 may not directly regulate the expression or degradation of beta-arrestin2."
27835898
USP33 increases the amount of ARRB2.
| 1
USP33 increases the amount of ARRB2. 1 / 1
| 1
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"Moreover, USP33 knock-down can significantly increase the ubiquitination level of beta-arrestin2 under SDF-1 stimulation."
27835898
USP33 affects CCP110
3 1 | 15 4
USP33 binds CCP110.
3 | 6 4
USP33 binds CCP110. 10 / 14
3 | 6 1
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"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
biogrid
No evidence text available
23486064
reach
"Alternatively, excessive amounts of USP33-DM might bind CP110, blocking it from accessing SCF Cyclin F."
23486064
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"USP33 interacts with CP110 and localizes to centrioles primarily in S and G2/M phases, the periods during which centrioles duplicate and elongate."
23486064
biogrid
No evidence text available
23486064
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"USP33 interacts with CP110 and localizes to centrioles primarily during S and G2/M phase, the period during which centrioles duplicate and elongate."
23486064
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"We investigated the interaction between USP33 and CP110 and found that CP110 binds to a region of USP33 within its catalytic domain (XREF_FIG)."
23486064
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"The interactions with USP20/33 are most likely direct because (1) bacterially expressed GST-USP33 and USP20 bind to in vitro translated CP110 in binding assays (XREF_SUPPLEMENTARY) and (2) Neurl4 depletion does not affect the binding between USP33 and CP110 (XREF_SUPPLEMENTARY)."
23486064
sparser
"We investigated the interaction between USP33 and CP110 and found that CP110 binds to a region of USP33 within its catalytic domain ( xref )."
23486064
biogrid
No evidence text available
23486064
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP33 activates CCP110.
| 4
USP33 activates CCP110. 4 / 8
| 4
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"Further, USP33 suppression significantly reduced CP110 protein half-life from ~ 4.5 hours to ~ 2 hours (XREF_SUPPLEMENTARY)."
23486064
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"USP33 promotes the generation of excessive centriolar foci due to elevated levels of CP110 because (1) over-expression of human or murine USP33 led to CP110 up-regulation in multiple cell lines (XREF_SUPPLEMENTARY) and (2) depletion of CP110 overrode USP33 mediated generation of centriolar foci (XREF_SUPPLEMENTARY)."
23486064
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"We observed that USP33 depletion did not lead to a reduction in RRM2 levels (XREF_SUPPLEMENTARY), indicating that USP33 specifically stabilizes CP110."
23486064
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"Further, depletion of USP33 in two PDAC cell lines (Panc1 and MiaPaCa2) led to a reduction in CP110 levels (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY), indicating that USP33 stabilizes CP110 in PDAC cells."
23486064
USP33 deubiquitinates CCP110.
1 | 4
USP33 deubiquitinates CCP110. 4 / 4
1 | 3
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"For example, USP33 deubiquitylates the centrosomal protein CP110, regulating centrosome biogenesis [76] and USP33 depletion has a co-operative effect with CDK2 on the CP110-dependent clustering function mentioned earlier [77]."
31506331
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"USP33 potently and specifically deubiquitinates CP110, but not other cyclin-F substrates."
23486064
ubibrowser
"USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110"
23486064
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"Thus, USP33 specifically de-ubiquitylates CP110 in vitro and in vivo, explaining how USP33 stabilizes CP110."
23486064
Modified USP33 leads to the deubiquitination of CCP110. 1 / 1
| 1
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"Remarkably, USP33 over-expression diminished CP110 ubiquitylation provoked by ectopic production of cyclin F in cells (XREF_FIG)."
23486064
USP33 inhibits CCP110.
| 1
USP33 inhibits CCP110. 1 / 3
| 1
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"Finally, CDK2 inhibitor response was enhanced when combined with knockdown of the deubiquitinase USP33 that in turn accelerates CP110 protein degradation."
26304236
VHL affects USP33
6 2 2 | 6 7
VHL binds USP33.
6 2 | 4 7
VHL binds USP33. 10 / 16
6 1 | 4 5
biogrid
No evidence text available
19706539
sparser
"The USP33-VHL interaction may have clinical significance because naturally occurring mutations that have been found in the beta-domain of USP33 disrupt the interaction between the two proteins."
18687060
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
biogrid
No evidence text available
19706539
biogrid
No evidence text available
11739384
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
hprd
No evidence text available
11739384
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Finally, we demonstrate that VDU1 is able to be ubiquitinated via a pVHL dependent pathway for proteasomal degradation, and VHL mutations that disrupt the interaction between VDU1 and pVHL abrogate the ubiquitination of VDU1."
11739384
biogrid
No evidence text available
11739384
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
VHL ubiquitinates USP33.
2 | 1
VHL ubiquitinates USP33. 3 / 3
2 | 1
ubibrowser
"In our previous studies, we have shown that VDU1 (pVHL-interacting deubiquitinating enzyme-1) can be ubiquitinated for rapid degradation in a pVHL-dependent manner"
12056827
reach
"We demonstrated that hVDU1 could interact with the beta-domain of pVHL and this interaction mediated the ubiquitination and degradation of VDU1 by pVHL E3 ligase [30]."
12056827
ubibrowser
"Finally, we demonstrate that VDU1 is able to be ubiquitinated via a pVHL-dependent pathway for proteasomal degradation, and VHL mutations that disrupt the interaction between VDU1 and pVHL abrogate the ubiquitination of VDU1"
11739384
VHL activates USP33.
| 1
VHL activates USP33. 1 / 1
| 1
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"Targeted degradation of VDU1 by pVHL could be crucial for regulating the ubiquitin-proteasome degradation pathway."
11739384
USP20 affects USP33
2 | 5 15
USP20 binds USP33.
2 | 4 15
USP20 binds USP33. 10 / 11
2 | 4 4
biogrid
No evidence text available
23486064
reach
"In the current studies and together with our previous report [30], we have demonstrated that both VDU1 and VDU2 also bind to the beta-domain of pVHL and several naturally occurring mutations in the be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"Moreover, pVHL30 is also known to interact with both USP33 and USP20, two enzymes belonging to the USP protein family, whose USP7 is a further member [ xref ]."
35205757
sparser
"Two DUBs, USP33 (or VDU-1) and USP20 (or VDU-2), interact with and regulate D2 [ xref ]."
29892818
biogrid
No evidence text available
23486064
reach
"The interactions with USP20/33 are most likely direct because (1) bacterially expressed GST-USP33 and USP20 bind to in vitro translated CP110 in binding assays (XREF_SUPPLEMENTARY) and (2) Neurl4 depletion does not affect the binding between USP33 and CP110 (XREF_SUPPLEMENTARY)."
23486064
sparser
"Like VDU1, VDU2 interacts with pVHL beta-domain and these two proteins can compete with each other to bind to pVHL."
12056827
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"In the current studies and together with our previous report [30] , we have demonstrated that both VDU1 and VDU2 also bind to the β-domain of pVHL and several naturally occurring mutations in the β-d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
USP20 activates USP33.
| 1
USP20 activates USP33. 1 / 1
| 1
reach
"The closely related DUBs, USP20 and USP33, deubiquitylate activated beta-adrenergic receptors as well as the adaptor and signalling protein beta-arrestin (in the case of USP33), to favour recycling from endosomes, despite largely being associated with the secretory pathway 75, 76, 77."
28064438
ARRB2 affects USP33
9 | 4 9
USP33 binds ARRB2. 10 / 22
9 | 4 8
sparser
"These conformation-specific interactions are supported by observations from two sets of assays conducted in vitro: (1) interaction of purified β-arrestin2 and USP33 is augmented by addition of a synth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23764054
biogrid
No evidence text available
19363159
sparser
"While examining the kinetics of agonist-dependent association of endogenously expressed USP33 with β-arrestin2, characteristic binding patterns were revealed ()."
24377933
biogrid
No evidence text available
19363159
sparser
"Upon β 2 AR activation, the recruited β-arrestins are rapidly ubiquitinated and deubiquitinated, and this is facilitated by a high-affinity interaction between β-arrestin2 and USP33."
21680031
biogrid
No evidence text available
19363159
reach
"Upon beta 2 AR activation, the recruited beta-arrestins are rapidly ubiquitinated and deubiquitinated, and this is facilitated by a high-affinity interaction between beta-arrestin2 and USP33."
21680031
sparser
"Upon stimulation of the βAR with isoproterenol, a robust increase in the association of β-arrestin2 and USP33 was detected."
24377933
biogrid
No evidence text available
19363159
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
USP33 binds AR and ARRB2. 1 / 1
| 1
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
USP33 affects USP20
2 | 4 15
USP20 binds USP33. 10 / 11
2 | 4 4
biogrid
No evidence text available
23486064
reach
"In the current studies and together with our previous report [30], we have demonstrated that both VDU1 and VDU2 also bind to the beta-domain of pVHL and several naturally occurring mutations in the be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"Moreover, pVHL30 is also known to interact with both USP33 and USP20, two enzymes belonging to the USP protein family, whose USP7 is a further member [ xref ]."
35205757
sparser
"Two DUBs, USP33 (or VDU-1) and USP20 (or VDU-2), interact with and regulate D2 [ xref ]."
29892818
biogrid
No evidence text available
23486064
reach
"The interactions with USP20/33 are most likely direct because (1) bacterially expressed GST-USP33 and USP20 bind to in vitro translated CP110 in binding assays (XREF_SUPPLEMENTARY) and (2) Neurl4 depletion does not affect the binding between USP33 and CP110 (XREF_SUPPLEMENTARY)."
23486064
sparser
"Like VDU1, VDU2 interacts with pVHL beta-domain and these two proteins can compete with each other to bind to pVHL."
12056827
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
sparser
"In the current studies and together with our previous report [30] , we have demonstrated that both VDU1 and VDU2 also bind to the β-domain of pVHL and several naturally occurring mutations in the β-d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
reach
"USP33 knockdown significantly upregulated tumor cell proliferation and metastasis."
29802710
reach
"USP33 inhibits cell proliferation, migration, and invasion."
27835898
reach
"Consequently, beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and cell invasion."
28506875
reach
"Furthermore, we found that beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and cell invasion."
28506875
reach
"Cellular studies with TPC-1 and BCPAP cells demonstrated that USP33 can attenuate the cell capacities of proliferation, migration and invasion."
29533940
reach
"Our data showed that knockdown of USP33 promoted the proliferation of both HeLa and HCT116 cells."
28506875
reach
"Taken together, we found that beta-TrCP attenuates USP33 mediated inhibition of cell proliferation and invasion.So far, the study of USP33 is still very limited."
28506875
reach
"Overexpression of USP33 can significantly inhibit cell proliferation, migration, and invasion."
27835898
reach
"Cell experiments showed that USP33 overexpression significantly inhibited the proliferation, migration, and invasion of GAC cells."
29802710
reach
"These results indicate that beta-TrCP attenuates USP33 mediated inhibition of cell proliferation."
28506875
reach
"Function experiments revealed that USP33 overexpression promoted the proliferation, migration and invasion of PC cells while the inhibition of USP33 expression in PC cells exhibited the opposite effect."
37322017
reach
"Next, functional rescue assays were performed to further verify that the miR-365a-3p-mediated downregulation of USP33 promotes the proliferation, migration, and invasion of lung cancer cells."
29743814
reach
"Additionally, we confirmed that 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) was critical for USP33-induced proliferation and aerobic glycolysis in OS cells, and the protein expression levels of PFKFB3 and USP33 were positively correlated in the OS tissues."
37034227
reach
"In conclusion, our study found that USP33 contributed to the proliferation and metastasis of pancreatic cancer through a positive feedback loop with TGF-β signaling pathway."
37322017
reach
"Using HeLa or HCT116 cells as a model, we analyzed the cell proliferation mediated by USP33."
28506875
reach
"Thus, USP33 promotes PCa cell proliferation and self-renewal by inhibiting the degradation of CTNNB1."
37076992
reach
"Moreover, overexpression of USP33 Cys : His can slightly promote cell proliferation and invasion (XREF_SUPPLEMENTARY), instead of the inhibiting effects caused by USP33 wild type."
27835898
reach
"Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma."
34470581
reach
"This is the first evidence for a lung cancer invasion and metastasis mechanism in which miR-365a-3p directly targets and downregulates USP33, which further promotes the proliferation, migration, and invasion activities of lung cancer."
29743814
reach
"On the other hand, USP33 knock-down promoted cell proliferation and invasion under SDF-1 stimulation; whereas dynasore (an internalization inhibitor) pretreatment in USP33 silencing cells showed a distinct antipromoting effect, revealing the participation of CXCR4 internalization in regulating tumor progress."
27835898
USP33 affects VHL
6 2 | 5 7
USP33 binds VHL.
6 2 | 4 7
VHL binds USP33. 10 / 16
6 1 | 4 5
biogrid
No evidence text available
19706539
sparser
"The USP33-VHL interaction may have clinical significance because naturally occurring mutations that have been found in the beta-domain of USP33 disrupt the interaction between the two proteins."
18687060
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
biogrid
No evidence text available
19706539
biogrid
No evidence text available
11739384
reach
"Further investigations are warranted to probe the biochemical and biological functions of the interaction between pVHL and VDU1 and VDU2 and to dissect functional and physiological differences between[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
hprd
No evidence text available
11739384
reach
"Together, our results suggest that VDU1 and VDU2 might be relevent to pVHL related tumorigenesis.In conclusion, our previously published results and current data indicate that the interaction between [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12056827
reach
"Finally, we demonstrate that VDU1 is able to be ubiquitinated via a pVHL dependent pathway for proteasomal degradation, and VHL mutations that disrupt the interaction between VDU1 and pVHL abrogate the ubiquitination of VDU1."
11739384
biogrid
No evidence text available
11739384
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
USP33 deubiquitinates VHL.
| 1
USP33 deubiquitinates ubiquitinated VHL. 1 / 1
| 1
reach
"Can VDU1 or VDU2 deubiquitinate the ubiquitinated pVHL to salvage it from degradation on certain conditions?"
12056827
CCP110 affects USP33
3 | 7 4
CCP110 binds USP33.
3 | 6 4
USP33 binds CCP110. 10 / 14
3 | 6 1
reach
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
biogrid
No evidence text available
23486064
reach
"Alternatively, excessive amounts of USP33-DM might bind CP110, blocking it from accessing SCF Cyclin F."
23486064
reach
"USP33 interacts with CP110 and localizes to centrioles primarily in S and G2/M phases, the periods during which centrioles duplicate and elongate."
23486064
biogrid
No evidence text available
23486064
reach
"USP33 interacts with CP110 and localizes to centrioles primarily during S and G2/M phase, the period during which centrioles duplicate and elongate."
23486064
reach
"We investigated the interaction between USP33 and CP110 and found that CP110 binds to a region of USP33 within its catalytic domain (XREF_FIG)."
23486064
reach
"The interactions with USP20/33 are most likely direct because (1) bacterially expressed GST-USP33 and USP20 bind to in vitro translated CP110 in binding assays (XREF_SUPPLEMENTARY) and (2) Neurl4 depletion does not affect the binding between USP33 and CP110 (XREF_SUPPLEMENTARY)."
23486064
sparser
"We investigated the interaction between USP33 and CP110 and found that CP110 binds to a region of USP33 within its catalytic domain ( xref )."
23486064
biogrid
No evidence text available
23486064
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
CCP110 inhibits USP33.
| 1
CCP110 inhibits USP33. 1 / 1
| 1
reach
"We found that centrosomal targeting of USP33 is partially dependent on CP110 because depletion of CP110 reduced USP33 localization to centrosomes (see below) (XREF_SUPPLEMENTARY)."
23486064
GroL2 affects USP33
| 7 10
USP33 binds groL2. 10 / 13
| 7 6
reach
"HSP56 interacted strongly with VDU1 f, compared to no interaction with GST alone or a trivial interaction with GST-beta2m."
19118533
sparser
"We then examined the interaction of the full-length VDU1 and hSP56 without or with pre-incubation of hSP56 with selenium."
19118533
reach
"The interaction between hSP56 and VDU1 was confirmed by yeast two-hybrid analysis and in vitro binding experiments."
19118533
sparser
"Notably, the results indicate that the interaction between hSP56 and VDU1 is direct, since purified proteins were used ( Fig. 1 B and C)."
19118533
sparser
"HSP56 interacted strongly with VDU1 f , compared to no interaction with GST alone or a trivial interaction with GST-β2m ( Fig. 1 B)."
19118533
reach
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA and anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm (XREF_FIG D)."
24874852
sparser
"The interaction between hSP56 and VDU1 was confirmed by yeast two-hybrid analysis and in vitro binding experiments."
19118533
reach
"HSP56 interacts with both VDU1 and VDU2."
24874852
reach
"Notably, the results indicate that the interaction between hSP56 and VDU1 is direct, since purified proteins were used."
19118533
sparser
"The full-length VDU1 interacts specifically with the selenium-replete form of hSP56 (hSP56/Se) in vitro , strongly suggesting that a physiological partner of VDU1 may be hSP56/Se ( Fig. 2 C)."
19118533
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP33 affects Neoplasm Invasiveness
| 1 16
USP33 inhibits Neoplasm Invasiveness. 9 / 9
| 9
reach
"Cell experiments showed that USP33 overexpression significantly inhibited the proliferation, migration, and invasion of GAC cells."
29802710
reach
"Cellular studies with TPC-1 and BCPAP cells demonstrated that USP33 can attenuate the cell capacities of proliferation, migration and invasion."
29533940
reach
"[USP33 suppresses lung adenocarcinoma lung cell invasion and metastasis by down-regulating SLIT2 and ROBO1 signaling pathway]."
30187867
reach
"USP33 inhibits cell proliferation, migration, and invasion."
27835898
reach
"Overexpression of USP33 can significantly inhibit cell proliferation, migration, and invasion."
27835898
reach
"Furthermore, we demonstrated that overexpression of beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and invasion."
28506875
reach
"Consequently, beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and cell invasion."
28506875
reach
"USP33 silencing can promote the migration, invasion and metastasis of lung adenocarcinoma cells in vitro, and the mechanism may involve IL-6 and SLIT2 and ROBO1 signaling pathways."
30187867
reach
"Furthermore, we found that beta-TrCP attenuated USP33 mediated inhibition of cell proliferation and cell invasion."
28506875
USP33 activates Neoplasm Invasiveness.
| 1 7
USP33 activates Neoplasm Invasiveness. 8 / 8
| 1 7
reach
"This is the first evidence for a lung cancer invasion and metastasis mechanism in which miR-365a-3p directly targets and downregulates USP33, which further promotes the proliferation, migration, and invasion activities of lung cancer."
29743814
reach
"On the other hand, USP33 knock-down promoted cell proliferation and invasion under SDF-1 stimulation; whereas dynasore (an internalization inhibitor) pretreatment in USP33 silencing cells showed a distinct antipromoting effect, revealing the participation of CXCR4 internalization in regulating tumor progress."
27835898
reach
"Function experiments revealed that USP33 overexpression promoted the proliferation, migration and invasion of PC cells while the inhibition of USP33 expression in PC cells exhibited the opposite effect."
37322017
reach
"Moreover, overexpression of USP33 Cys : His can slightly promote cell proliferation and invasion (XREF_SUPPLEMENTARY), instead of the inhibiting effects caused by USP33 wild type."
27835898
reach
"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 and c-Met axis."
32835698
reach
"We found that USP33 knockdown inhibited the invasion and metastasis in HCC cells both in vitro and in vivo, which was partly dependent on c-Met."
32835698
reach
"Next, functional rescue assays were performed to further verify that the miR-365a-3p-mediated downregulation of USP33 promotes the proliferation, migration, and invasion of lung cancer cells."
29743814
eidos
"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 / c-Met axis ."
32835698
USP33 affects BTRC
| 5 11
BTRC binds USP33. 10 / 14
| 5 9
sparser
"We found that USP33(△DSG) can also interact with β-TrCP ( Fig. 3 B )."
28506875
reach
"We found that USP33 (^ DSG) can also interact with beta-TrCP."
28506875
sparser
"Furthermore, we found that the WD40 motif of β-TrCP and 201-400 amino acid motif of USP33 are required for the interaction between β-TrCP and USP33."
28506875
reach
"Beta-TrCP can also interact with FH-USP33 (^ DSG), indicating that the interaction between beta-TrCP and USP33 is independent of DSG motif of USP33."
28506875
sparser
"Our data showed that USP33 was able to interact with β-TrCP-WT, but unable to interact with β-TrCP-△WD40 ( Fig. 3 D )."
28506875
sparser
"Collectively, we found that the WD40 motif of β-TrCP and 201–400 amino acid motif of USP33 are necessary for the interaction between β-TrCP and USP33."
28506875
sparser
"Β-TrCP is able to interact with USP33, and promotes the ubiquitination and proteasomal degradation of USP33."
28506875
reach
"These results suggest that the effect of beta-TrCP on USP33 is independent of the classic DSG motif.Since beta-TrCP promotes USP33 ubiquitin dependent degradation, then we assessed the interaction bet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
sparser
"The interaction of β-TrCP with these USP33 mutants was evaluated."
28506875
reach
"We also revealed that beta-TrCP interacted with USP33 independently of the classic binding motif for beta-TrCP, and mediated USP33 degradation via the ubiquitin proteasome pathway."
28506875
BTRC binds USP33 and infC. 1 / 1
| 1
sparser
"Therefore, USP33 isoform 3 is suitable for the analysis of interaction between β-TrCP and USP33-DSG motif."
28506875
BTRC binds USP33 and FH. 1 / 1
| 1
sparser
"Β-TrCP can also interact with FH-USP33(△DSG) ( Fig. 3 B ), indicating that the interaction between β-TrCP and USP33 is independent of DSG motif of USP33."
28506875
USP33 affects MYC
| 7 4
USP33 binds MYC.
| 4 4
USP33 binds MYC. 8 / 8
| 4 4
reach
"IP experiments revealed that USP33 could bind and deubiquitinate c-Myc."
33718387
reach
"IP experiments showed that USP33 interacted with c-Myc (XREF_FIG), and USP33 knockdown profoundly enhanced c-Myc ubiquitination (XREF_FIG)."
33718387
sparser
"These data suggested that USP33 may bind and deubiquitinate c-Myc in 22RV1 cells."
33718387
reach
"USP33 could bind and deubiquitinate c-Myc."
33718387
reach
"These data suggested that USP33 may bind and deubiquitinate c-Myc in 22RV1 cells."
33718387
sparser
"IP experiments revealed that USP33 could bind and deubiquitinate c-Myc."
33718387
sparser
"IP experiments showed that USP33 interacted with c-Myc ( xref ), and USP33 knockdown profoundly enhanced c-Myc ubiquitination ( xref )."
33718387
sparser
"USP33 could bind and deubiquitinate c-Myc."
33718387
USP33 deubiquitinates MYC.
| 2
USP33 deubiquitinates MYC. 2 / 2
| 2
reach
"USP33, as a deubiquitinating enzyme, could deubiquitinate c-Myc, an important proliferation regulator."
33718387
reach
"IP experiments showed that USP33 interacted with c-Myc (XREF_FIG), and USP33 knockdown profoundly enhanced c-Myc ubiquitination (XREF_FIG)."
33718387
USP33 increases the amount of MYC.
| 1
USP33 increases the amount of MYC. 1 / 1
| 1
reach
"USP33 knockdown significantly reduced c-Myc protein expression (XREF_FIG), but did not affect c-Myc mRNA expression (XREF_FIG)."
33718387
MiR-365a-3p affects USP33
| 10
MiR-365a-3p activates USP33.
| 7
MiR-365a-3p activates USP33. 7 / 7
| 7
reach
"Functional rescue assays demonstrated that miR-365a-3p promoted proliferation, migration, and invasion by downregulating USP33."
29743814
reach
"This further suggested that miR-365a-3p promotes the proliferation of lung cancer cells by downregulating USP33."
29743814
reach
"The above series of in vitro experiments suggested that miR-365a-3p promotes lung cancer progression by downregulating USP33; however, the signalling pathways involved in this process remain unknown."
29743814
reach
"This is the first evidence for a lung cancer invasion and metastasis mechanism in which miR-365a-3p directly targets and downregulates USP33, which further promotes the proliferation, migration, and invasion activities of lung cancer."
29743814
reach
"MiR-365a-3p enhance the migration and invasion of lung cancer cells by inhibiting ubiquitin specific peptidase 33 (USP33)/ slit guidance ligand 2 (SLIT2)/ roundabout guidance Receptor 1 (ROBO1) signaling pathway (101)."
32595638
reach
"This suggested that miR-365a-3p directly targets and binds the USP33 3 ' UTR."
29743814
reach
"To further verify that miR-365a-3p directly targets and downregulates USP33, the wild-type 3 ' UTR of USP33 (WT USP33 3 ' UTR) or a mutated USP33 3 ' UTR (Mut USP33 3 ' UTR) was cloned into a dual-luciferase UTR vector and then co-transfected with agomiR-365 or a negative control (agomiR-NC) into A549 and SPC-A-1 cells."
29743814
MiR-365a-3p inhibits USP33.
| 2
MiR-365a-3p inhibits USP33. 2 / 2
| 2
reach
"However, these results did not clarify the signalling pathway through which miR-365a-3p downregulates USP33 to promote lung carcinogenesis."
29743814
reach
"USP33 is a downstream target gene of miR-365a-3p and is downregulated by miR-365a-3p."
29743814
MiR-365a-3p binds USP33.
| 1
USP33 binds miR-365a-3p. 1 / 1
| 1
reach
"Thus, we sought to determine whether miR-365a-3p interacts with USP33."
29743814
USP33 affects Neoplasm Metastasis
| 1 7
USP33 activates Neoplasm Metastasis.
| 1 4
USP33 activates Neoplasm Metastasis. 5 / 5
| 1 4
reach
"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 and c-Met axis."
32835698
reach
"We found that USP33 knockdown inhibited the invasion and metastasis in HCC cells both in vitro and in vivo, which was partly dependent on c-Met."
32835698
eidos
"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 / c-Met axis ."
32835698
reach
"Secondly, the details of mechanisms by which USP33 promotes GAC growth and metastasis are still unclear; for example, the effects of USP33 on cell viability may be caused by either suppressing proliferation or enhancing apoptosis."
29802710
reach
"In conclusion, our study found that USP33 contributed to the proliferation and metastasis of pancreatic cancer through a positive feedback loop with TGF-β signaling pathway."
37322017
USP33 inhibits Neoplasm Metastasis.
| 3
USP33 inhibits Neoplasm Metastasis. 3 / 3
| 3
reach
"USP33 silencing can promote the migration, invasion and metastasis of lung adenocarcinoma cells in vitro, and the mechanism may involve IL-6 and SLIT2 and ROBO1 signaling pathways."
30187867
reach
"[USP33 suppresses lung adenocarcinoma lung cell invasion and metastasis by down-regulating SLIT2 and ROBO1 signaling pathway]."
30187867
reach
"USP33 knockdown significantly upregulated tumor cell proliferation and metastasis."
29802710
USP33 affects E7
5 | 1 2
USP33 binds E7. 2 / 2
1 | 1
reach
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45] ."
33922750
virhostnet
No evidence text available
28786561
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 affects ARRB
| 8
ARRB binds USP33. 7 / 7
| 7
sparser
"Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors."
19363159
sparser
"The association of USP33 and β-arrestin 2 itself appears to be dependent on the class of 7TMR as activation of the β2-adrenergic receptor (β2AR), a Class A receptor known to have a transient interaction with β-arrestins, enhances the association of β-arrestin 2 with USP33 [ xref ]."
21476968
sparser
"Specific conformations of β-arrestins induced by different 7TMR binding can also determine the kinetics and stability of interaction of β-arrestin with the deubiquitinating enzyme USP33 [ xref ]."
21680031
sparser
"Conversely, stimulation of the vasopressin V2R, a Class B receptor known to have prolonged interaction with β-arrestins, does not enhance β-arrestin 2-USP33 interaction."
21476968
sparser
"These DUBs are constitutively bound to the cell-surface β 2 ARs; however, β 2 AR–USP association decreases upon agonist activation, while simultaneously agonist stimulation leads to the recruitment of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23764054
sparser
"The detailed steps to assay the kinetics of β-arrestin–USP33 interaction are described later."
24377933
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968
ARRB binds USP33 and 7TMR. 1 / 1
| 1
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968
USP33 is modified
2 | 6
USP33 is ubiquitinated.
| 6
USP33 is ubiquitinated. 6 / 6
| 6
sparser
"Finally, we demonstrate that VDU1 is able to be ubiquitinated via a pVHL-dependent pathway for proteasomal degradation, and VHL mutations that disrupt the interaction between VDU1 and pVHL abrogate the ubiquitination of VDU1."
11739384
sparser
"In our previous studies, we have shown that VDU1 (pVHL-interacting deubiquitinating enzyme-1) can be ubiquitinated for rapid degradation in a pVHL-dependent manner."
12056827
sparser
"Here, our study for the first time uncovered that β-TrCP plays the roles in tumor cell proliferation and invasion by promoting ubiquitination and degradation of USP33."
28506875
sparser
"Unexpectedly, we found that overexpression of β-TrCP can also increase the ubiquitination of FH-USP33(△DSG) ( Fig. 2 D ), and knockdown of β-TrCP also decreased the ubiquitin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
sparser
"USP33 was found to be ubiquitinated in a VHL-dependent manner which targeted it for proteasomal degradation, and VHL mutations that disrupt the protein’s interaction with the DUB abrogated USP33 ubiquitination."
18687060
sparser
"Data from the literature indicate that pVHL30 mediates the ubiquitination and degradation of both USP33 and USP20, in turn down-regulating the pathways controlled by these two proteins [ xref ]."
35205757
USP33 is phosphorylated.
2 |
USP33 is phosphorylated on S439. 2 / 2
2 |
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
MYC affects USP33
| 4 4
USP33 binds MYC. 8 / 8
| 4 4
reach
"IP experiments revealed that USP33 could bind and deubiquitinate c-Myc."
33718387
reach
"IP experiments showed that USP33 interacted with c-Myc (XREF_FIG), and USP33 knockdown profoundly enhanced c-Myc ubiquitination (XREF_FIG)."
33718387
sparser
"These data suggested that USP33 may bind and deubiquitinate c-Myc in 22RV1 cells."
33718387
reach
"USP33 could bind and deubiquitinate c-Myc."
33718387
reach
"These data suggested that USP33 may bind and deubiquitinate c-Myc in 22RV1 cells."
33718387
sparser
"IP experiments revealed that USP33 could bind and deubiquitinate c-Myc."
33718387
sparser
"IP experiments showed that USP33 interacted with c-Myc ( xref ), and USP33 knockdown profoundly enhanced c-Myc ubiquitination ( xref )."
33718387
sparser
"USP33 could bind and deubiquitinate c-Myc."
33718387
E7 affects USP33
5 | 1 2
USP33 binds E7. 2 / 2
1 | 1
reach
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45] ."
33922750
virhostnet
No evidence text available
28786561
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 binds E7. 1 / 1
1 |
virhostnet
No evidence text available
28786561
ARRB affects USP33
| 8
ARRB binds USP33. 7 / 7
| 7
sparser
"Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors."
19363159
sparser
"The association of USP33 and β-arrestin 2 itself appears to be dependent on the class of 7TMR as activation of the β2-adrenergic receptor (β2AR), a Class A receptor known to have a transient interaction with β-arrestins, enhances the association of β-arrestin 2 with USP33 [ xref ]."
21476968
sparser
"Specific conformations of β-arrestins induced by different 7TMR binding can also determine the kinetics and stability of interaction of β-arrestin with the deubiquitinating enzyme USP33 [ xref ]."
21680031
sparser
"Conversely, stimulation of the vasopressin V2R, a Class B receptor known to have prolonged interaction with β-arrestins, does not enhance β-arrestin 2-USP33 interaction."
21476968
sparser
"These DUBs are constitutively bound to the cell-surface β 2 ARs; however, β 2 AR–USP association decreases upon agonist activation, while simultaneously agonist stimulation leads to the recruitment of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23764054
sparser
"The detailed steps to assay the kinetics of β-arrestin–USP33 interaction are described later."
24377933
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968
ARRB binds USP33 and 7TMR. 1 / 1
| 1
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968
USP33 affects SELENBP1
2 | 2 1
SELENBP1 binds USP33. 5 / 7
2 | 2 1
reach
"SELENBP1 has also been implicated in ubiquitination from a study demonstrating the binding of SELENBP1 to von Hippel- Lindau protein (pVHL) - interacting deubiquitinating enzyme 1 (VDU1) that was abolished with the incubation of beta-mercaptoethanol, which dissociates selenium, suggesting a selenium dependent interaction of SELENBP1 and VDU1."
23805071
sparser
"SELENBP1 has also been implicated in ubiquitination from a study demonstrating the binding of SELENBP1 to von Hippel- Lindau protein (pVHL)- interacting deubiquitinating enzyme 1 (VDU1) that was abolished with the incubation of β-mercaptoethanol, which dissociates selenium (Jeong et al., xref ), suggesting a selenium dependent interaction of SELENBP1 and VDU1."
23805071
reach
"Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium dependent manner."
19118533
biogrid
No evidence text available
19118533
biogrid
No evidence text available
19118533
USP33 affects IRF9
| 2 5
USP33 binds IRF9.
| 5
USP33 binds IRF9. 5 / 5
| 5
sparser
"SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia."
33936086
sparser
"Disruption of USP33-IRF9 axis stimulate the non-canonical activation of pro-inflammatory genes from microglia and lead to severe neuroinflammation inside CNS ( xref )."
33936086
sparser
"Schematic flow diagram representing the mechanistic route utilized by SARS-CoV-2 Spike protein to target USP33-IRF9 axis via modulating exosomal miR-148a to activate the human microglial cells."
33936086
sparser
"Disruption of USP33-IRF9 axis stimulate the non-canonical activation of pro-inflammatory genes from microglia and lead to severe neuroinflammation inside CNS ( Figure 7 )."
33936086
sparser
"Figure 7: SARS-CoV-2 Spike targets USP33-IRF9 axis via Exosomal miR-148a to activate Human Microglia."
33936086
USP33 inhibits IRF9.
| 1
USP33 inhibits IRF9. 1 / 1
| 1
reach
"They further found that miR-148a specifically blocks USP33 and miR-590 specifically blocks IRF9."
35436552
USP33 increases the amount of IRF9.
| 1
USP33 increases the amount of IRF9. 1 / 1
| 1
reach
"microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels."
33936086
USP33 affects DIO2
5 1 1 |
USP33 binds DIO2.
5 1 |
USP33 binds DIO2. 6 / 6
5 1 |
biogrid
No evidence text available
17452445
hprd
No evidence text available
12865408
biogrid
No evidence text available
12865408
biogrid
No evidence text available
12865408
biogrid
No evidence text available
12865408
biogrid
No evidence text available
24196352
USP33 deubiquitinates DIO2.
1 |
USP33 deubiquitinates DIO2. 1 / 1
1 |
ubibrowser
"Ubiquitinated D2 can be either targeted to proteasomal degradation or reactivated by deubiquitination, a process that is mediated by the deubiquitinases USP20/33 and is important in adaptive thermogenesis."
22967761
USP33 affects CXCR4
| 5
USP33 inhibits CXCR4.
| 3
USP33 inhibits CXCR4. 3 / 5
| 3
reach
"We demonstrated that USP33 overexpression can attenuate CXCR4 internalization, while USP33 knock-down showed the opposite effect."
27835898
reach
"We also demonstrated that in the LoVo cells transfected with CXCR4, overexpression of beta-arrestin2 can further promote cell proliferation, while co-overexpression of USP33 can attenuate the oncogenetic effects of CXCR4 (XREF_SUPPLEMENTARY)."
27835898
reach
"On the other hand, we tested the level of total receptors after SDF-1 stimulation and demonstrated that USP33 knock-down can increase the degradation of CXCR4, while USP33 overexpression can inhibit its degradation."
27835898
USP33 activates CXCR4.
| 2
USP33 activates CXCR4. 2 / 2
| 2
reach
"and silencing USP33 can promote internalization and degradation of CXCR4."
27835898
reach
"We have proved that USP33 knock-down can promote the internalization and degradation of CXCR4."
27835898
SELENBP1 affects USP33
2 | 2 1
SELENBP1 binds USP33. 5 / 7
2 | 2 1
reach
"SELENBP1 has also been implicated in ubiquitination from a study demonstrating the binding of SELENBP1 to von Hippel- Lindau protein (pVHL) - interacting deubiquitinating enzyme 1 (VDU1) that was abolished with the incubation of beta-mercaptoethanol, which dissociates selenium, suggesting a selenium dependent interaction of SELENBP1 and VDU1."
23805071
sparser
"SELENBP1 has also been implicated in ubiquitination from a study demonstrating the binding of SELENBP1 to von Hippel- Lindau protein (pVHL)- interacting deubiquitinating enzyme 1 (VDU1) that was abolished with the incubation of β-mercaptoethanol, which dissociates selenium (Jeong et al., xref ), suggesting a selenium dependent interaction of SELENBP1 and VDU1."
23805071
reach
"Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium dependent manner."
19118533
biogrid
No evidence text available
19118533
biogrid
No evidence text available
19118533
DIO2 affects USP33
5 1 | 1
DIO2 binds USP33.
5 1 |
USP33 binds DIO2. 6 / 6
5 1 |
biogrid
No evidence text available
17452445
hprd
No evidence text available
12865408
biogrid
No evidence text available
12865408
biogrid
No evidence text available
12865408
biogrid
No evidence text available
12865408
biogrid
No evidence text available
24196352
DIO2 deubiquitinates USP33.
| 1
DIO2 deubiquitinates USP33. 1 / 1
| 1
reach
"DIO2 works as a dimer that associates with Hedgehog inducible ubiquitin ligase WD repeat and SOCS box containing 1 (WSB-1) [XREF_BIBR], ubiquitin conjugases UBC6 and UBC-7 [XREF_BIBR], and DIO2 specific deubiquitinating enzymes ubiquitin specific peptidase 20 (USP20), and ubiquitin specific peptidase 33 (USP33) [XREF_BIBR]."
31222623
USP33 affects Slit-Robo
| 6
USP33 activates Slit-Robo. 6 / 6
| 6
reach
"USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration."
25242263
reach
"USP33 can also inhibit tumor progression of colorectal cancer by targeting Slit-Robo signaling pathway or beta-arrestin signaling [XREF_BIBR, XREF_BIBR]."
29574466
reach
"USP33 can regulate centrosome amplication [XREF_BIBR], recycling of beta-adrenergic receptor [XREF_BIBR, XREF_BIBR], and mediate Slit-Robo signaling in carcinoma [XREF_BIBR, XREF_BIBR]."
27835898
reach
"USP33 mediates Slit-Robo signaling in lung cancer cell migration."
24981056
reach
"USP33, a new player in lung cancer, mediates Slit-Robo signaling."
24981056
reach
"Recently, Huang et al. found that the USP33 mediates Slit-Robo signaling in inhibiting CRC cell migration [XREF_BIBR]."
26674478
USP33 affects GCGR
| 5 1
USP33 deubiquitinates GCGR.
| 3
USP33 deubiquitinates GCGR. 3 / 3
| 3
reach
"Our data suggest that USP33 constitutively deubiquitinates the GCGR, whereas both STAMBP and USP33 deubiquitinate agonist-activated GCGRs at early endosomes."
32967969
reach
"USP33 knockdown drastically increases GCGR ubiquitination in quiescent cells; one possibility is that USP33 deubiquitinates and protects newly synthesized receptors from 26S proteasomal degradation."
32967969
reach
"Our data suggest that USP33 constitutively deubiquitinates the GCGR, whereas both STAMBP and USP33 deubiquitinate agonist activated GCGRs at early endosomes."
33453899
USP33 binds GCGR.
| 1 1
USP33 binds GCGR. 2 / 2
| 1 1
reach
"The USP33-GCGR complex likely dissembles at later times of agonist, as suggested by the decreasing interaction seen in the pulldown assay at 60 min of agonist stimulation (Fig. 7, C and D)."
32967969
sparser
"The USP33-GCGR complex likely dissembles at later times of agonist, as suggested by the decreasing interaction seen in the pulldown assay at 60 min of agonist stimulation ( xref , C and D )."
32967969
USP33 activates GCGR.
| 1
USP33 activates GCGR. 1 / 1
| 1
reach
"Overall, these data strongly suggest that both STAMBP and USP33 deubiquitinate agonist-activated GCGR, whereas the basal ubiquitination of GCGR is governed only by USP33 activity."
32967969
USP33 affects DUSP1
| 4 1 1
USP33 binds DUSP1.
| 1 1 1
USP33 binds DUSP1. 1 / 1
| 1
reach
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
DUSP1 binds USP33. 1 / 1
| 1
isi
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
JNK binds USP33 and DUSP1. 1 / 1
| 1
sparser
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
USP33 activates DUSP1.
| 2
USP33 activates DUSP1. 2 / 2
| 2
reach
"Therefore, USP33 overexpression in prostate cancer may contribute to docetaxel resistance by inhibiting the degradation of its partner DUSP1, leading to impaired JNK activation and apoptosis."
31857702
reach
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
USP33 deubiquitinates DUSP1.
| 1
USP33 leads to the deubiquitination of DUSP1. 1 / 1
| 1
reach
"Mechanistically, we found that USP33 could inhibit the Lys48 (K48)-linked polyubiquitination of DUSP1."
31857702
USP33 affects AR
| 3 3
USP33 binds AR.
| 1 3
USP33 binds AR. 2 / 2
| 1 1
reach
"Usp33 interacts with beta 2 AR but mechanistically how this occurs is not known."
23201781
sparser
"Usp33 interacts with β 2 AR but mechanistically how this occurs is not known."
23201781
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP33 binds AR and ARRB2. 1 / 1
| 1
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
USP33 deubiquitinates AR.
| 2
USP33 leads to the deubiquitination of AR. 2 / 2
| 2
reach
"104 Two DUBs USP20 and USP33 have been shown to mediate deubiquitination of beta 2 AR."
26055058
reach
"Ubiquitination of the beta 2 AR is reversed by the deubiquitinases USP20 and USP33, which tonically associate with the beta 2 AR."
23166351
USP33 affects RALB
2 1 | 2
USP33 deubiquitinates RALB.
1 | 2
USP33 deubiquitinates RALB. 3 / 3
1 | 2
reach
"Starvation induced deubiquitination of RALB by USP33 (XREF_FIG c) prevents the association with SEC5 and triggers the interaction to another exocyst subunit, EXO84 [XREF_BIBR]."
26445063
ubibrowser
"Review"
26445063
reach
"Another example in the context of early signaling events is the deubiquitination of RALB by USP33, which enables the interaction of non modified RALB with Beclin 1 complexes in order to induce autophagy."
26445063
USP33 binds RALB.
2 |
USP33 binds RALB. 2 / 2
2 |
biogrid
No evidence text available
24056301
biogrid
No evidence text available
24056301
IRF9 affects USP33
| 5
USP33 binds IRF9. 5 / 5
| 5
sparser
"SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia."
33936086
sparser
"Disruption of USP33-IRF9 axis stimulate the non-canonical activation of pro-inflammatory genes from microglia and lead to severe neuroinflammation inside CNS ( xref )."
33936086
sparser
"Schematic flow diagram representing the mechanistic route utilized by SARS-CoV-2 Spike protein to target USP33-IRF9 axis via modulating exosomal miR-148a to activate the human microglial cells."
33936086
sparser
"Disruption of USP33-IRF9 axis stimulate the non-canonical activation of pro-inflammatory genes from microglia and lead to severe neuroinflammation inside CNS ( Figure 7 )."
33936086
sparser
"Figure 7: SARS-CoV-2 Spike targets USP33-IRF9 axis via Exosomal miR-148a to activate Human Microglia."
33936086
HERC2 affects USP33
| 4 1
HERC2 binds USP33.
| 1 1
USP33 binds HERC2. 1 / 1
| 1
reach
"13 HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin mediated proteasomal degradation."
25476789
FBXL5 binds USP33 and HERC2. 1 / 1
| 1
sparser
"More recently, HERC2 was shown to interact with p53 through the p53 tetramerization domain, thus affecting p53 oligomerization and downstream transcriptional activity. xref HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin-mediated proteasomal degradation. xref , xref HERC2 has also been shown to regulate centrosome morphology and ubiquitin ligase activity through interactions with NEURL4 and UBE3A (also known as E6AP), respectively."
25476789
HERC2 inhibits USP33.
| 1
HERC2 inhibits USP33. 1 / 1
| 1
reach
"HERC2 knockdown increased levels of the USP33 protein and decreased levels of the p21 protein."
27528230
HERC2 increases the amount of USP33.
| 1
HERC2 increases the amount of USP33. 1 / 1
| 1
reach
"Knockdown of HERC2 increased the levels of USP33, confirming that HERC2 functions as an ubiquitin ligase for USP33."
28977907
HERC2 activates USP33.
| 1
HERC2 activates USP33. 1 / 1
| 1
reach
"In favour of the hypothesis that HectPH1 might regulate cAR1 signaling, rather recently it has been reported in mammalian cells that HERC2 targets the deubiquitinating enzyme USP33, which is involved in regulating beta2 adrenergic receptor recycling and re-sensitization [XREF_BIBR]."
29048338
Valproic acid affects USP33
4 |
Valproic acid decreases the amount of USP33.
3 |
Valproic acid decreases the amount of USP33. 3 / 3
3 |
ctd
No evidence text available
23179753
ctd
No evidence text available
25192806
ctd
No evidence text available
27188386
Valproic acid increases the amount of USP33.
1 |
Valproic acid increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
17183730
GroL2 affects USP20
| 4
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
USP33 affects cell migration
| 3
USP33 activates cell migration.
| 2
reach
"Expression of the C163A-mutant USP33 abolished Slit suppression of H1299 cell migration, supporting that deubiquitinating activity of USP33 is important in mediating Slit activity in inhibiting lung cancer cell migration."
24981056
reach
"For instance, USP33 contributes to Slit-mediated breast cancer cell migration [49]."
| PMC
USP33 inhibits cell migration.
| 1
USP33 inhibits cell migration. 1 / 1
| 1
reach
"Similarly, the downregulation of USP33 (a ubiquitin ligase enzyme) reduces the stability of the ROBO1 receptor in lung cancer cells 29 and breast cancer cell migration 30."
33318575
USP33 affects SLIT2
| 4
USP33 inhibits SLIT2.
| 2
USP33 inhibits SLIT2. 2 / 2
| 2
reach
"Enhanced USP33 expression increased Slit2 inhibition of cell migration (XREF_FIG), whereas knocking down USP33 blocked the inhibitory effect of Slit on cell migration (XREF_FIG)."
25242263
reach
"Ectopic expression of Slit2 significantly reduced the number of lung metastasis sites, and USP33 overexpression enhanced the inhibitory effect of Slit2 on tumor metastasis (XREF_FIG, XREF_SUPPLEMENTARY)."
25242263
USP33 increases the amount of SLIT2.
| 1
USP33 increases the amount of SLIT2. 1 / 1
| 1
reach
"USP33 silencing in A549 and SPC-A-1 cells significantly promoted the cell migration, invasion and metastasis and obviously down-regulated the expressions of SLIT2 and ROBO1."
30187867
USP33 activates SLIT2.
| 1
USP33 activates SLIT2. 1 / 1
| 1
reach
"Moreover, studies have shown that USP33 mediated SLIT2 and ROBO1 signalling participates in the development of cancer [XREF_BIBR, XREF_BIBR]."
29743814
USP33 affects PRKN
| 4
USP33 deubiquitinates PRKN. 2 / 2
| 2
reach
"USP33 deubiquitinates PRKN and parkin and antagonizes its role in mitophagy."
31432739
reach
"Cellular and in vitro assays illustrated that USP33 deubiquitinates PRKN in a DUB activity dependent manner."
31432739
USP33 deubiquitinates PRKN on K435. 2 / 2
| 2
reach
"Different from USP30 which regulates substrates of Parkin, USP33 can directly and selectively deubiquitinate Parkin at Lys435 and preferentially remove K6, K11, K48, and K63-linked ubiquitin conjugates from Parkin."
34804365
reach
"USP33 prefers to remove K6, K11, K48 and K63 linked ubiquitin conjugates from PRKN, and deubiquitinates PRKN mainly at Lys435."
31432739
USP33 affects ELOC
2 2 |
ELOC binds USP33. 3 / 3
2 1 |
hprd
No evidence text available
11739384
biogrid
No evidence text available
11739384
biogrid
No evidence text available
19706539
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
USP33 affects CTNNB1
| 3 1
USP33 binds CTNNB1.
| 1 1
USP33 binds CTNNB1. 2 / 2
| 1 1
sparser
"USP33 interacts with CTNNB1, and stabilizes CTNNB1 by suppressing its degradation."
37076992
reach
"USP33 interacts with CTNNB1, and stabilizes CTNNB1 by suppressing its degradation."
37076992
USP33 inhibits CTNNB1.
| 1
USP33 inhibits CTNNB1. 1 / 1
| 1
reach
"Thus, USP33 promotes PCa cell proliferation and self-renewal by inhibiting the degradation of CTNNB1."
37076992
USP33 deubiquitinates CTNNB1.
| 1
USP33 deubiquitinates CTNNB1. 1 / 1
| 1
reach
"USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells."
37076992
USP20 affects groL2
| 4
USP20 binds USP33 and groL2. 4 / 4
| 4
sparser
"Similar to our previous demonstration with hSP56 and VDU1 interactions (14), VDU2 (red fluorescence from anti-HA/anti-mouse IgG-Texas Red) and hSP56 (green fluorescence from hSP56-EGFP) overlapped in the cytoplasm ( xref D)."
24874852
sparser
"HSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"HSP56 was co-immunoprecipitated specifically with either VDU1-HA or VDU2-HA using anti-HA antibody, but not using normal mouse IgG ( xref C), confirming that hSP56 interacts with both VDU1 and VDU2."
24874852
sparser
"We investigated the interactions of hSP56 with VDU1 and VDU2 further by co-immunoprecipitation."
24874852
ELOC affects USP33
2 2 |
ELOC binds USP33. 3 / 3
2 1 |
hprd
No evidence text available
11739384
biogrid
No evidence text available
11739384
biogrid
No evidence text available
19706539
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
E3_Ub_ligase affects USP33
| 3 1
E3_Ub_ligase ubiquitinates USP33.
| 1 1
E3_Ub_ligase ubiquitinates USP33. 2 / 2
| 1 1
sparser
"We demonstrated that hVDU1 could interact with the β-domain of pVHL and this interaction mediated the ubiquitination and degradation of VDU1 by pVHL E3 ligase [30] ."
12056827
reach
"We demonstrated that hVDU1 could interact with the beta-domain of pVHL and this interaction mediated the ubiquitination and degradation of VDU1 by pVHL E3 ligase [30]."
12056827
E3_Ub_ligase increases the amount of USP33.
| 1
E3_Ub_ligase increases the amount of USP33. 1 / 1
| 1
reach
"However, how cellular USP33 levels are regulated remains largely unexplored.Here we discovered that the E3 ligase beta-TrCP did not reduce USP33 mRNA levels, but significantly downregulated USP33 prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
E3_Ub_ligase decreases the amount of USP33.
| 1
E3_Ub_ligase decreases the amount of USP33. 1 / 1
| 1
reach
"However, how cellular USP33 levels are regulated remains largely unexplored.Here we discovered that the E3 ligase beta-TrCP did not reduce USP33 mRNA levels, but significantly downregulated USP33 prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28506875
AR affects USP33
| 1 3
USP33 binds AR. 2 / 2
| 1 1
reach
"Usp33 interacts with beta 2 AR but mechanistically how this occurs is not known."
23201781
sparser
"Usp33 interacts with β 2 AR but mechanistically how this occurs is not known."
23201781
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP33 binds AR and ARRB2. 1 / 1
| 1
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
USP33 affects centriole
| 3
USP33 activates centriole. 3 / 3
| 3
eidos
"Knockdown of USP33 suppressed centriole amplification in NudCL2 KO cells ( Fig. 6g-i ) ."
31427565
eidos
"Moreover , knockdown of USP33 reverses centriole amplification in both NudCL2 KO and HERC2-depleted cells ."
31427565
eidos
"Moreover , downregulation of USP33 reverses centriole amplification induced by NudCL2 KO or HERC2 knockdown ( Figs ."
31427565
USP33 affects cell growth
| 3
USP33 inhibits cell growth.
| 2
USP33 inhibits cell growth. 2 / 2
| 2
reach
"MTT results showed that USP33 can inhibit cellular growth (XREF_FIG)."
29802710
reach
"Unlike USP33, which has been reported to inhibit mitogen activated protein kinase (MAPK) activation pathway and suppress hepatoma cell growth 26, our study suggests that USP21 activates ERK1/2 to promote HCC cell proliferation."
29706623
USP33 activates cell growth.
| 1
USP33 activates cell growth. 1 / 1
| 1
reach
"Functional assays suggested that USP33 promoted OS cell growth through the induction of aerobic glycolysis."
37034227
USP33 affects TRAF6
2 | 1
USP33 binds TRAF6.
2 |
TRAF6 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
21525354
biogrid
No evidence text available
21525354
USP33 deubiquitinates TRAF6.
| 1
USP33 deubiquitinates TRAF6. 1 / 1
| 1
reach
"We report that two ubiquitin specific peptidases, USP20 and USP33, deubiquitinate TRAF6 and suppress IL-1beta-induced NF-kappaB activation."
| PMC
USP33 affects Slit
| 3
USP33 activates Slit.
| 2
USP33 activates Slit. 2 / 2
| 2
reach
"USP33 mediates Slit signaling in lung cancer cells, and this requires the enzymatic activity of USP33, because expression of USP33 mutant (C163A) abolishes the Slit activity in lung cancer cells."
24981056
reach
"Our previous work on breast cancer and the current data from lung cancer suggest that USP33 may mediate Slit signaling in different cancer cells through different mechanisms."
24981056
USP33 inhibits Slit.
| 1
USP33 inhibits Slit. 1 / 1
| 1
reach
"Downregulation of USP33 inhibits Slit and Robo signaling pathway and is associated with poor patient survival of glioma."
32972109
USP33 affects SP1
| 1 1 1
USP33 binds SP1.
| 1 1
SP1 binds USP33. 2 / 2
| 1 1
reach
"Mechanistically, USP33 directly bound SP1 and decreased its ubiquitination, thereby upregulating c-Met expression."
32835698
sparser
"Mechanistically, USP33 directly bound SP1 and decreased its ubiquitination, thereby upregulating c-Met expression."
32835698
USP33 deubiquitinates SP1.
| 1
USP33 deubiquitinates SP1. 1 / 1
| 1
trips
"USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma."
32835698
USP33 affects Robo1 receptor
| 3
USP33 binds Robo1 receptor. 3 / 3
| 3
reach
"Additionally, the deubiquinating enzyme USP33 interacts with the Robo1 receptor to regulate Slit mediated repulsion of commissural axons from the midline in chick XREF_BIBR."
21655271
reach
"We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor."
19684588
reach
"Here we report that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor."
19684588
USP33 affects NEURL4
1 | 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP33 binds NEURL4. 1 / 1
1 |
biogrid
No evidence text available
23486064
USP33 affects JNK
| 2 1
USP33 inhibits JNK.
| 2
USP33 bound to DUSP1 inhibits JNK. 1 / 1
| 1
reach
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
USP33 inhibits JNK. 1 / 1
| 1
reach
"More importantly, DUSP1 overexpression could reverse the USP33 knockdown induced JNK activation and apoptosis in docetaxel treated prostate cancer cells."
31857702
USP33 binds JNK.
| 1
JNK binds USP33 and DUSP1. 1 / 1
| 1
sparser
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
USP33 affects CRC
| 3
ROBO1 binds USP33 and CRC. 2 / 2
| 2
sparser
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
25242263
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
USP33 affects ARRB1
2 1 |
USP33 binds ARRB1.
2 |
USP33 binds ARRB1. 2 / 2
2 |
biogrid
No evidence text available
19363159
biogrid
No evidence text available
19363159
USP33 deubiquitinates ARRB1.
1 |
USP33 deubiquitinates ARRB1. 1 / 1
1 |
ubibrowser
"We now report the discovery that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins."
19363159
USP33 affects ADRB2
1 1 | 1
USP33 deubiquitinates ADRB2.
1 |
USP33 deubiquitinates ADRB2. 1 / 1
1 |
USP33 binds ADRB2.
1 |
USP33 binds ADRB2. 1 / 1
1 |
biogrid
No evidence text available
23166351
USP33 activates ADRB2.
| 1
USP33 activates ADRB2. 1 / 1
| 1
reach
"It has been reported that USP33 can promote the internalization of beta2-adrenergic receptor and vasopressin receptor 2 [XREF_BIBR, XREF_BIBR]."
27835898
USP20 affects CCP110
| 3
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
SP1 affects USP33
| 2 1
SP1 binds USP33.
| 1 1
SP1 binds USP33. 2 / 2
| 1 1
reach
"Mechanistically, USP33 directly bound SP1 and decreased its ubiquitination, thereby upregulating c-Met expression."
32835698
sparser
"Mechanistically, USP33 directly bound SP1 and decreased its ubiquitination, thereby upregulating c-Met expression."
32835698
SP1 inhibits USP33.
| 1
SP1 inhibits USP33. 1 / 1
| 1
reach
"SP1 overexpression abolished the roles of USP33 downregulation in modulating the activation of PI3K/AKT signaling, cell growth, apoptosis, and cell cycle."
34470581
Robo1 receptor affects USP33
| 3
USP33 binds Robo1 receptor. 3 / 3
| 3
reach
"Additionally, the deubiquinating enzyme USP33 interacts with the Robo1 receptor to regulate Slit mediated repulsion of commissural axons from the midline in chick XREF_BIBR."
21655271
reach
"We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor."
19684588
reach
"Here we report that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor."
19684588
ROBO1 affects CRC
| 3
ROBO1 binds USP33 and CRC. 2 / 2
| 2
sparser
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
25242263
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
RALB affects USP33
2 | 1
RALB binds USP33.
2 |
USP33 binds RALB. 2 / 2
2 |
biogrid
No evidence text available
24056301
biogrid
No evidence text available
24056301
RALB activates USP33.
| 1
RALB activates USP33. 1 / 1
| 1
eidos
"Mechanistically , we found that DHA degraded RalB , inhibited USP33 expression , and triggered autophagy ."
32577124
NEURL4 affects USP33
1 | 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP33 binds NEURL4. 1 / 1
1 |
biogrid
No evidence text available
23486064
GCGR affects USP33
| 2 1
GCGR binds USP33.
| 1 1
USP33 binds GCGR. 2 / 2
| 1 1
reach
"The USP33-GCGR complex likely dissembles at later times of agonist, as suggested by the decreasing interaction seen in the pulldown assay at 60 min of agonist stimulation (Fig. 7, C and D)."
32967969
sparser
"The USP33-GCGR complex likely dissembles at later times of agonist, as suggested by the decreasing interaction seen in the pulldown assay at 60 min of agonist stimulation ( xref , C and D )."
32967969
GCGR activates USP33.
| 1
GCGR activates USP33. 1 / 1
| 1
reach
"When we overexpressed USP33-CH in GCGR stable HEK-293 cells, we observed a significant increase in basal ubiquitination of the GCGR, but the mutant construct did not have a similar pronounced effect in blocking deubiquitination of agonist-activated GCGRs (Fig. S5, A and B)."
32967969
DUSP1 affects USP33
| 1 1 1
USP33 binds DUSP1. 1 / 1
| 1
reach
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
DUSP1 binds USP33. 1 / 1
| 1
isi
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
JNK binds USP33 and DUSP1. 1 / 1
| 1
sparser
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
CRC affects USP33
| 3
ROBO1 binds USP33 and CRC. 2 / 2
| 2
sparser
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
25242263
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
CCP110 affects USP20
| 3
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
Vinclozolin affects USP33
2 |
Vinclozolin increases the amount of USP33. 2 / 2
2 |
ctd
No evidence text available
23555832
ctd
No evidence text available
23034163
Selenium atom affects USP33
1 | 1
Selenium atom decreases the amount of USP33.
1 |
Selenium atom decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
19244175
Selenium atom binds USP33.
| 1
Selenium atom binds USP33. 1 / 1
| 1
reach
"However recently VDU1 was identified as a protein interacting with SELENBP1 and it was shown that (i) SELENBP1 and VDU1 were co-localized in the perinuclear region, suggesting that their interaction w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21338716
MiR-206 affects USP33
| 2
USP33 binds miR-206. 2 / 2
| 2
reach
"To study whether miR-206 interacts with USP33, 22RV1 cells were transfected with reporter plasmid pGL3-USP33 WT, which contains the predicted binding site of miR-206, or pGL3 USP33 mutant, which contains mutations in the predicted binding site (XREF_FIG)."
33718387
reach
"RIP analysis followed by qRT-PCR assay demonstrated that USP33 mRNA and miR-206 were immunoprecipitated by Ago2 (XREF_FIG), which confirmed the interaction between miR-206 and USP33."
33718387
Dihydroartemisinin decreases the amount of USP33. 2 / 2
| 2
reach
"In this study, it was shown that DHA reduced the expression level of RalB and USP33 in three different types of cancer cells."
32577124
reach
"Mechanistically, we found that DHA degraded RalB, inhibited USP33 expression, and triggered autophagy."
32577124
Copper atom affects USP33
2 |
Copper atom increases the amount of USP33.
1 |
Copper atom increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
30556269
Copper atom decreases the amount of USP33.
1 |
Copper atom decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
26293553
VSX2 affects USP33
2 |
VSX2 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
VHL affects USP20
| 2
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
VAPB affects USP33
2 |
VAPB binds USP33. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
Ubiquitin affects USP33
| 1 1
Ubiquitin binds USP33.
| 1
Ubiquitin binds USP33. 1 / 1
| 1
isi
"By downregulating candidate deubiquitinases that are either linked with GPCR trafficking or localized on endosomes, we identified signal-transducing adaptor molecule binding protein (STAMBP) and ubiquitin specific protease 33 (USP33) as cognate deubiquitinases for the GCGR."
32967969
Ubiquitin activates USP33.
| 1
Ubiquitin activates USP33. 1 / 1
| 1
reach
"The inhibitory function of Slit2-Robo1 is mediated by ubiquitin specific protease 33 (USP33) via deubiquitinating and stabilizing Robo1."
30896071
USP33 affects miR-206
| 2
USP33 binds miR-206. 2 / 2
| 2
reach
"To study whether miR-206 interacts with USP33, 22RV1 cells were transfected with reporter plasmid pGL3-USP33 WT, which contains the predicted binding site of miR-206, or pGL3 USP33 mutant, which contains mutations in the predicted binding site (XREF_FIG)."
33718387
reach
"RIP analysis followed by qRT-PCR assay demonstrated that USP33 mRNA and miR-206 were immunoprecipitated by Ago2 (XREF_FIG), which confirmed the interaction between miR-206 and USP33."
33718387
USP33 activates hepatic stellate cell activation. 2 / 2
| 2
reach
"Conversely, overexpression of USP33 caused a contrast function on hepatic stellate cell activation and glycolysis activation, which was inhibited by c-Myc inhibitor 10058-F4."
37267862
reach
"USP33 knockdown inhibited hepatic stellate cell activation and glycolysis in gerbils with NAFLD-associated fibrosis."
37267862
USP33 affects glioma cell migration
| 2
USP33 inhibits glioma cell migration. 2 / 2
| 2
eidos
"USP33 inhibits glioma cell migration by Slit / Robo signaling pathway ."
32972109
eidos
"Mechanistically , USP33 inhibits glioma cell migration by regulating the function of Slit / Robo signaling pathway ."
32972109
USP33 affects beta-arrestins
| 2
USP33 leads to the deubiquitination of beta-arrestins. 2 / 2
| 2
reach
"We now report the discovery that the deubiquitinating enzyme ubiquitin specific protease 33 (USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins."
19363159
reach
"Deubiquitination of beta-arrestins is also regulated by agonist activation of the beta2AR and other GPCRs and is mediated by USP20 and USP33 and is important for beta, arrestin, and beta2AR complex disassembly, lysosomal sorting and signaling [XREF_BIBR, XREF_BIBR] (XREF_FIG)."
30353650
USP33 affects beta-arrestin
| 2
USP33 activates beta-arrestin. 2 / 2
| 2
reach
"USP33 can also inhibit tumor progression of colorectal cancer by targeting Slit-Robo signaling pathway or beta-arrestin signaling [XREF_BIBR, XREF_BIBR]."
29574466
reach
"The closely related DUBs, USP20 and USP33, deubiquitylate activated beta-adrenergic receptors as well as the adaptor and signalling protein beta-arrestin (in the case of USP33), to favour recycling from endosomes, despite largely being associated with the secretory pathway 75, 76, 77."
28064438
USP33 affects apoptotic process
| 2
USP33 inhibits apoptotic process. 2 / 2
| 2
reach
"More importantly, DUSP1 overexpression could reverse the USP33 knockdown induced JNK activation and apoptosis in docetaxel treated prostate cancer cells."
31857702
reach
"Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma."
34470581
USP33 affects VSX2
2 |
VSX2 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP33 affects VAPB
2 |
VAPB binds USP33. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP33 affects USP33
| 2
USP33 bound to BTRC inhibits USP33. 1 / 1
| 1
reach
"We also revealed that beta-TrCP interacted with USP33 independently of the classic binding motif for beta-TrCP, and mediated USP33 degradation via the ubiquitin proteasome pathway."
28506875
USP33 inhibits USP33. 1 / 1
| 1
reach
"Furthermore, beta-TrCP also increased the ubiquitination of USP33 (^ DSG) and decreased the protein stability of USP33 (^ DSG)."
28506875
USP33 affects USP29
| 2
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
USP33 affects Slit2-Robo1
| 2
USP33 inhibits Slit2-Robo1. 2 / 2
| 2
reach
"Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT."
30896071
reach
"Several downstream effectors, including Abl [XREF_BIBR], Dock [XREF_BIBR], Ena (32), ERK1/2 [XREF_BIBR], small Rho GTPases [XREF_BIBR], USP33 [XREF_BIBR] and Vilse [XREF_BIBR], have been reported to mediate the inhibitory effect of Slit2-Robo1 signaling on cell motility, proliferation, apoptosis and angiogenesis in different cell types."
27923383
USP33 affects STN1
2 |
USP33 binds STN1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
USP33 affects SRGAP1
| 2
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
SRGAP1 binds USP33. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
USP33 affects SPINT2
2 |
SPINT2 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP33 affects RALA
2 |
USP33 binds RALA. 2 / 2
2 |
biogrid
No evidence text available
24056301
biogrid
No evidence text available
24056301
USP33 affects PFKFB3
| 1 1
USP33 ubiquitinates PFKFB3.
| 1
USP33 leads to the ubiquitination of PFKFB3. 1 / 1
| 1
reach
"Deubiquitinase USP33 promotes the glycolysis and growth of osteosarcoma by modifying PFKFB3 ubiquitination and degradation."
37034227
USP33 binds PFKFB3.
| 1
USP33 binds PFKFB3. 1 / 1
| 1
sparser
"Collectively, these findings reveal a mechanism by which OS cells survive in a dystrophic tumor microenvironment, with the USP33-PFKFB3 axis as a critical driver of aerobic glycolysis and OS proliferation."
37034227
USP33 affects MET
| 2
USP33 activates MET. 2 / 2
| 2
eidos
"Mechanistically , USP33 directly bound SP1 and decreased its ubiquitination , thereby upregulating c-Met expression ."
32835698
eidos
"We found that USP33 knockdown inhibited the invasion and metastasis in HCC cells both in vitro and in vivo , which was partly dependent on c-Met ."
32835698
USP33 affects ID2
| 2
USP33 deubiquitinates ID2.
| 1
USP33 deubiquitinates ID2. 1 / 1
| 1
reach
"Therefore, we posit that overexpressed USP1 interferes with mesenchymal stem cell differentiation and thereby fosters the development of malignant mesenchymal cell populations.Our screen for DUBs capa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21925315
USP33 binds ID2.
| 1
USP33 binds ID2. 1 / 1
| 1
reach
"USP33 binding ID2 may have precluded ID2 recognition by the proteasome and prevented its degradation."
21925315
USP33 affects Hemagglutinins
| 2
sparser
"In marked contrast, HA-VDU1 interacted strongly with hSP56/Se ( Fig. 2 C)."
19118533
sparser
"No significant interaction between HA-VDU1 and BSA or hSP56 was observed."
19118533
USP33 affects HERC2
| 1 1
USP33 binds HERC2. 1 / 1
| 1
reach
"13 HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin mediated proteasomal degradation."
25476789
FBXL5 binds USP33 and HERC2. 1 / 1
| 1
sparser
"More recently, HERC2 was shown to interact with p53 through the p53 tetramerization domain, thus affecting p53 oligomerization and downstream transcriptional activity. xref HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin-mediated proteasomal degradation. xref , xref HERC2 has also been shown to regulate centrosome morphology and ubiquitin ligase activity through interactions with NEURL4 and UBE3A (also known as E6AP), respectively."
25476789
USP33 affects FLVCR1
| 2
USP33 activates FLVCR1. 2 / 2
| 2
reach
"Herein, we report that USP33 silencing inhibits PCa cell survival and self-renewal."
37076992
reach
"Thus, USP33 promotes PCa cell proliferation and self-renewal by inhibiting the degradation of CTNNB1."
37076992
USP33 affects EPAS1
| 1 1
USP33 deubiquitinates EPAS1.
| 1
USP33 deubiquitinates EPAS1. 1 / 1
| 1
reach
"USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells."
35191554
USP33 binds EPAS1.
| 1
USP33 binds EPAS1. 1 / 1
| 1
sparser
"USP33 is preferentially induced in glioma stem cells by hypoxia and interacts with HIF-2alpha, leading to its stabilization through deubiquitination."
35191554
USP33 affects ELOB
1 1 |
ELOB binds USP33. 1 / 1
1 |
biogrid
No evidence text available
19706539
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
USP33 affects EIF6
1 1 |
USP33 binds EIF6. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
USP33 affects DDX56
1 1 |
DDX56 binds USP33. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
USP33 affects Cell Survival
| 1 1
USP33 activates Cell Survival. 2 / 2
| 1 1
eidos
"USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells ."
37076992
reach
"Herein, we report that USP33 silencing inhibits PCa cell survival and self-renewal."
37076992
USP33 affects CH
| 2
USP33 binds CH. 2 / 2
| 2
sparser
"We also tested a catalytically inactive USP33 in which the cysteine and histidine residues of the active site are mutated (USP33-CH) for its effect on GCGR ubiquitination."
32967969
sparser
"When we overexpressed USP33-CH in GCGR stable HEK-293 cells, we observed a significant increase in basal ubiquitination of the GCGR, but the mutant construct did not have a similar pronounced effect in blocking deubiquitination of agonist-activated GCGRs ( xref )."
32967969
USP33 affects CGRRF1
2 |
CGRRF1 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP33 affects ATF3
| 1 1
USP33 binds ATF3.
| 1
USP33 binds ATF3. 1 / 1
| 1
sparser
"Dengue Virus Degrades USP33-ATF3 Axis via Extracellular Vesicles to Activate Human Microglial Cells."
32848034
USP33 activates ATF3.
| 1
USP33 activates ATF3. 1 / 1
| 1
reach
"Reduced USP33 in turn decreases the stability of cellular ATF3 protein via deubiquitylation."
32848034
USP29 affects USP33
| 2
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
USP20 affects VHL
| 2
USP20 binds VHL and USP33. 2 / 2
| 2
sparser
"In conclusion, our previously published results and current data indicate that the interaction between pVHL and VDU1 or VDU2 mediates the ubiquitination and degradation of these two proteins."
12056827
sparser
"Based on their amino acid sequence homology and functional interaction with pVHL, VDU1 and VDU2 define a subfamily of ubiquitin specific processing proteases."
12056827
USP20 affects NEURL4
| 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
TRAF6 affects USP33
2 |
TRAF6 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
21525354
biogrid
No evidence text available
21525354
STN1 affects USP33
2 |
USP33 binds STN1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
SRGAP1 affects USP33
| 2
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
SRGAP1 binds USP33. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
SPINT2 affects USP33
2 |
SPINT2 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
RALA affects USP33
2 |
USP33 binds RALA. 2 / 2
2 |
biogrid
No evidence text available
24056301
biogrid
No evidence text available
24056301
NEURL4 affects USP20
| 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
JNK affects USP33
| 2
JNK binds USP33.
| 1
JNK binds USP33 and DUSP1. 1 / 1
| 1
sparser
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
JNK activates USP33.
| 1
JNK activates USP33. 1 / 1
| 1
sparser
"More importantly, DUSP1 overexpression could reverse the USP33 knockdown-induced JNK activation and apoptosis in docetaxel-treated prostate cancer cells."
31857702
Hypoxia affects USP33
| 1 1
Hypoxia activates USP33. 2 / 2
| 1 1
reach
"USP33 is preferentially induced in glioma stem cells by hypoxia and interacts with HIF-2alpha, leading to its stabilization through deubiquitination."
35191554
eidos
"USP33 is preferentially induced in glioma stem cells by hypoxia and interacts with HIF-2alpha , leading to its stabilization through deubiquitination ."
35191554
Hemagglutinins affects USP33
| 2
sparser
"In marked contrast, HA-VDU1 interacted strongly with hSP56/Se ( Fig. 2 C)."
19118533
sparser
"No significant interaction between HA-VDU1 and BSA or hSP56 was observed."
19118533
ELOB affects USP33
1 1 |
ELOB binds USP33. 1 / 1
1 |
biogrid
No evidence text available
19706539
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
EIF6 affects USP33
1 1 |
USP33 binds EIF6. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
E7 affects USP29, and USP33
| 2
USP29 binds USP33 and E7. 2 / 2
| 2
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [ xref ]."
33922750
sparser
"The Gaussia princeps luciferase protein complementation assay shows that USP15 interacts with the key oncoprotein human papillomavirus (HPV) E6, while USP29 and USP33 bind to E7 protein, suggesting that cellular DUBs impact HPV tumorigenesis by regulating the stability of the viral proteins [45]."
33922750
DDX56 affects USP33
1 1 |
DDX56 binds USP33. 2 / 2
1 1 |
hprd
No evidence text available
16169070
biogrid
No evidence text available
16169070
CTNNB1 affects USP33
| 1 1
USP33 binds CTNNB1. 2 / 2
| 1 1
sparser
"USP33 interacts with CTNNB1, and stabilizes CTNNB1 by suppressing its degradation."
37076992
reach
"USP33 interacts with CTNNB1, and stabilizes CTNNB1 by suppressing its degradation."
37076992
CRC affects ROBO1, and USP33
| 2
ROBO1 binds USP33 and CRC. 2 / 2
| 2
sparser
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
25242263
CH affects USP33
| 2
USP33 binds CH. 2 / 2
| 2
sparser
"We also tested a catalytically inactive USP33 in which the cysteine and histidine residues of the active site are mutated (USP33-CH) for its effect on GCGR ubiquitination."
32967969
sparser
"When we overexpressed USP33-CH in GCGR stable HEK-293 cells, we observed a significant increase in basal ubiquitination of the GCGR, but the mutant construct did not have a similar pronounced effect in blocking deubiquitination of agonist-activated GCGRs ( xref )."
32967969
CGRRF1 affects USP33
2 |
CGRRF1 binds USP33. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
CCP110 affects NEURL4, USP20, and USP33
| 2
USP20 binds USP33, CCP110, and NEURL4. 2 / 2
| 2
sparser
"Thus, we sought to examine whether USP20 and USP33 interact with the CP110-Neurl4 complex to regulate centrosome function."
23486064
sparser
"We immunoprecipitated each protein from cell lysates and found that endogenous USP33 and USP20 specifically interact with CP110 and Neurl4, but not with two other CP110-interacting proteins, Cep97 and cyclin F ( xref )."
23486064
ARRB1 affects USP33
2 |
USP33 binds ARRB1. 2 / 2
2 |
biogrid
No evidence text available
19363159
biogrid
No evidence text available
19363159
Vasopressin affects USP33
| 1
Vasopressin activates USP33. 1 / 1
| 1
reach
"However, vasopressin (V 2 R agonist) promoted dissociation of beta-arrestin2 and USP33."
24377933
Valdecoxib affects USP33
1 |
Valdecoxib increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
24136188
Trichloroethene affects USP33
1 |
Trichloroethene decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
19448997
Thapsigargin affects USP33
1 |
Thapsigargin increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
24648495
Tetrachloromethane increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
31150632
Sulforaphane affects USP33
1 |
Sulforaphane decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
30529165
SiUSP33#4 affects USP33
| 1
SiUSP33#4 decreases the amount of USP33. 1 / 1
| 1
reach
"siUSP33 # 4, but not siCtl, suppressed USP33 expression in the spinal cord (XREF_SUPPLEMENTARY)."
19684588
Schizandrin B affects USP33
1 |
Schizandrin B increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
31150632
Response to cold affects USP33
1 |
Response to cold increases the amount of USP33. 1 / 1
1 |
bel
"VDU1, but not VDU2, is markedly increased in brown adipocytes by norepinephrine or cold exposure, further amplifying the increase in D2 activity that results from catecholamine-stimulated de novo synthesis."
12865408
Rapamycin treatment affects USP33
| 1
Rapamycin treatment activates USP33. 1 / 1
| 1
eidos
"Consistent with the data of RalB , the expression level of USP33 was decreased by DHA or rapamycin treatment , while did not change with 3-MA ( Fig. 6a , b ) ."
32577124
Phlorizin affects USP33
1 |
Phlorizin decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
22538082
Mono(2-ethylhexyl) phthalate decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
31059758
Mitochondrial DNA damage affects USP33
1 |
Mitochondrial DNA damage decreases the amount of USP33. 1 / 1
1 |
bel
"To better understand the consequences of mtDNA deletions, we microarrayed six cell types containing mtDNA deletions from KSS and CPEO patients. Indicated are transcripts shared and downregulated in cells harboring mtDNA deletions in >3 experiments (Table 4); Differentially expressed genes were identified by comparing GeneChips designated as baseline (muscles, myoblasts, fibroblasts, and lymphoblasts from healthy subjects, fusion control cell lines, and parental 143B cells) with the ones that represent the experimental parameters (muscles, myoblasts, fibroblasts, and lymphoblasts from patients, mutant cybrids, and 143B rho zero cells) using a difference in mean fluorescence ? 30 and a P value < 0.05; 37 downregulated genes; 26 upregulated genes;"
17157191
Methyl methanesulfonate increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
23649840
Methamphetamine affects USP33
1 |
Methamphetamine decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
29802913
reach
"miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway."
37256445
Jinfukang affects USP33
1 |
Jinfukang decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
27392435
InfC affects USP33
| 1
BTRC binds USP33 and infC. 1 / 1
| 1
sparser
"Therefore, USP33 isoform 3 is suitable for the analysis of interaction between β-TrCP and USP33-DSG motif."
28506875
Indometacin affects USP33
1 |
Indometacin increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
28628672
Hydroxyurea affects USP33
| 1
Hydroxyurea activates USP33. 1 / 1
| 1
reach
"Further, we investigated whether USP33 depletion could affect centrosome reduplication in cells treated with hydroxyurea to induce prolonged S-phase."
23486064
Hydroperoxide affects USP33
1 |
Hydroperoxide decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
18951874
Hydralazine affects USP33
1 |
Hydralazine increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
17183730
Hsa-miR-877-5p affects USP33
1 |
Hsa-miR-877-5p decreases the amount of USP33. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-148b-3p affects USP33
1 |
Hsa-miR-148b-3p decreases the amount of USP33. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
17612493
Hsa-miR-1-3p affects USP33
1 |
Hsa-miR-1-3p decreases the amount of USP33. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18668040
Gold atom affects USP33
1 |
Gold atom decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
25523186
Gentamycin affects USP33
1 |
Gentamycin increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
22061828
Flutamide affects USP33
1 |
Flutamide increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
24136188
Fbxw1 affects USP33
| 1
Fbxw1 decreases the amount of USP33. 1 / 1
| 1
reach
"We noticed that endogenous USP33 protein levels were gradually downregulated by HA-beta-TrCP in a dose dependent manner."
28506875
Dicrotophos affects USP33
1 |
Dicrotophos decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
28302478
Diazinon affects USP33
1 |
Diazinon increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
29108742
Dexamethasone affects USP33
1 |
Dexamethasone increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
28628672
Cyclosporin A affects USP33
1 |
Cyclosporin A decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
25562108
Copper(II) sulfate decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
19549813
Cobalt dichloride affects USP33
1 |
Cobalt dichloride increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
24386269
Chlorpyrifos affects USP33
1 |
Chlorpyrifos decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
20350560
Bisphenol F affects USP33
1 |
Bisphenol F increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
28628672
Bisphenol A affects USP33
1 |
Bisphenol A increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
25181051
Bile acid affects USP33
| 1
Bile acid increases the amount of USP33. 1 / 1
| 1
reach
"Bile acid promoted USP33 expression and inhibiting its receptor reversed hepatic stellate cell activation in gerbils with NAFLD-associated fibrosis."
37267862
Beta-Arr2 affects USP33
| 1
USP33 binds beta-Arr2. 1 / 1
| 1
reach
"Strikingly, recruitment of USP33 to beta-Arr2 depends on the receptor class, in agreement with previous finding that receptor class determines the kinetics of beta-Arr2 deubiquitylation [XREF_BIBR]."
22988512
Benzo[a]pyrene diol epoxide I decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
19150397
Autophagy affects USP33
| 1
Autophagy inhibits USP33. 1 / 1
| 1
eidos
"These results suggested that enhanced autophagy can inhibit the expression of USP33 ."
32577124
Aflatoxin M1 affects USP33
1 |
Aflatoxin M1 decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
30928695
ZNRF4 affects USP33
1 |
ZNRF4 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
28514442
ZFR affects USP33
1 |
ZFR binds USP33. 1 / 1
1 |
biogrid
No evidence text available
19615732
YP_009227196 affects USP33
1 |
USP33 binds YP_009227196. 1 / 1
1 |
virhostnet
No evidence text available
30037810
Vitamin E affects USP33
1 |
Vitamin E decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
19244175
VHL affects ELOC
1 |
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
VAPA affects USP33
1 |
VAPA binds USP33. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects β -AR recycling
| 1
USP33 activates β -AR recycling. 1 / 1
| 1
reach
"USP33 deubiquitinates the β -AR and promotes β -AR recycling, but USP33 does not deubiquitinate the β -AR; additional substrates identified for USP33 include β-arrestin 2 and TRAF6, among other nonreceptor proteins (13, 18, 19, 60, 61, 62)."
32967969
reach
"It has been reported that USP33 can promote the internalization of beta2-adrenergic receptor and vasopressin receptor 2 [XREF_BIBR, XREF_BIBR]."
27835898
USP33 affects type 2 deiodinase
| 1
USP33 activates type 2 deiodinase. 1 / 1
| 1
reach
"Expression patterns of WSB-1 and USP-33 underlie cell specific posttranslational control of type 2 deiodinase in the rat brain."
17628004
USP33 affects stability cellular ATF3 protein
| 1
USP33 activates stability cellular ATF3 protein. 1 / 1
| 1
eidos
"Reduced USP33 in turn decreases the stability of cellular ATF3 protein via deubiquitylation ."
32848034
USP33 affects selenium atom
| 1
Selenium atom binds USP33. 1 / 1
| 1
reach
"However recently VDU1 was identified as a protein interacting with SELENBP1 and it was shown that (i) SELENBP1 and VDU1 were co-localized in the perinuclear region, suggesting that their interaction w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21338716
USP33 affects proteolysis
| 1
USP33 inhibits proteolysis. 1 / 1
| 1
reach
"Finally, CDK2 inhibitor response was enhanced when combined with knockdown of the deubiquitinase USP33 that in turn accelerates CP110 protein degradation."
26304236
USP33 affects post-endocytic sorting receptor endosomes autophagosomes
| 1
USP33 activates post-endocytic sorting receptor endosomes autophagosomes. 1 / 1
| 1
eidos
"The post-endocytic sorting of the receptor from the endosomes to the autophagosomes is modulated by the proteases USP20 and USP33 [ 149 ] ."
30126257
USP33 affects polyubiquitination
| 1
USP33 inhibits polyubiquitination. 1 / 1
| 1
sparser
"Mechanistically, we found that USP33 could inhibit the Lys48 (K48)-linked polyubiquitination of DUSP1."
31857702
USP33 affects pVHL-E3 ligase
| 1
USP33 deubiquitinates pVHL-E3 ligase. 1 / 1
| 1
reach
"Can VDU1 and VDU2 deubiquitinate the ubiquitinated downstream targets of pVHL-E3 ligase, such as HIF-1alpha, therefore, counteract or modify the ubiquitinating function of VCB-E3 ligase?"
12056827
USP33 affects neuron migration
| 1
USP33 activates neuron migration. 1 / 1
| 1
reach
"In utero knockdown of USP1, USP4, and USP20 in the mouse cerebellum disrupts granule neuron morphogenesis, while knockdown of USP30 and USP33 disrupts granule neuron migration (79)."
35662507
USP33 affects miR-365a-3p
| 1
USP33 binds miR-365a-3p. 1 / 1
| 1
reach
"Thus, we sought to determine whether miR-365a-3p interacts with USP33."
29743814
USP33 affects miR-3591-5p
| 1
USP33 inhibits miR-3591-5p. 1 / 1
| 1
reach
"Ectopic expression of USP33 or PPM1A partially abolished the effects of miR-3591-5p on EMT and TGF-beta / Smad2/3 activation."
30308513
USP33 affects lysosomal trafficking
| 1
USP33 inhibits lysosomal trafficking. 1 / 1
| 1
reach
"A first group is implicated in cell trafficking and endocytosis, such as the golgi protein Galntl4, Rabep1 (or rabaptin), implicated in endocytosis XREF_BIBR, XREF_BIBR, annexin A8 (Anxa 8) which directly regulates organization and function of the late endosome XREF_BIBR, XREF_BIBR, and the deubiquitinase USP33 which inhibits the lysosomal trafficking XREF_BIBR, XREF_BIBR."
23593401
reach
"VDU1 and VDU2, a closely related isoform, have been shown to increase half-life of type 2 iodothyronine deiodinase by their deubiquitinating activity [23]."
19118533
USP33 affects invasion metastasis cells
| 1
USP33 activates invasion metastasis cells. 1 / 1
| 1
eidos
"We found that USP33 knockdown inhibited the invasion and metastasis in HCC cells both in vitro and in vivo , which was partly dependent on c-Met ."
32835698
USP33 affects infC
| 1
BTRC binds USP33 and infC. 1 / 1
| 1
sparser
"Therefore, USP33 isoform 3 is suitable for the analysis of interaction between β-TrCP and USP33-DSG motif."
28506875
USP33 affects hydroxyurea
| 1
USP33 inhibits hydroxyurea. 1 / 1
| 1
reach
"Similar to CP110 ablation 2, depletion of USP33 significantly inhibited hydroxyurea (HU)-induced centrosome amplification in two cell lines (XREF_FIG and XREF_SUPPLEMENTARY)."
23486064
reach
"USP33 knockdown inhibited hepatic stellate cell activation and glycolysis in gerbils with NAFLD-associated fibrosis."
37267862
USP33 affects fatty acid
| 1
USP33 activates fatty acid. 1 / 1
| 1
reach
"USP33 promotes nonalcoholic fatty acid disease-associated fibrosis in gerbils via the c-myc signaling."
37267862
USP33 inhibits docetaxel anhydrous. 1 / 1
| 1
reach
"More importantly, DUSP1 overexpression could reverse the USP33 knockdown induced JNK activation and apoptosis in docetaxel treated prostate cancer cells."
31857702
USP33 affects colorectal57 breast58 cancer cell migration
| 1
USP33 inhibits colorectal57 breast58 cancer cell migration. 1 / 1
| 1
eidos
"On the other hand , Usp33 inhibits colorectal57 and breast58 cancer cell migration , and therefore may also be an inhibitor of trophoblast migration ."
30986076
USP33 activates cellular component biogenesis. 1 / 1
| 1
reach
"Similarly, USP33 promotes centrosome biogenesis via specific and potent stabilization of the centriolar coiled coil protein CP110, and USP22 has been found to strengthen the NAD dependent histone deacetylase Sirt1 to antagonize p53 activation."
24756567
USP33 affects cell activation
| 1
USP33 activates cell activation. 1 / 1
| 1
reach
"These data also point to hepatic stellate cells as a key cell type that may respond to liver fibrosis via USP33-induced cell activation and glycolysis."
37267862
USP33 affects c-Myc ubiquitination
| 1
USP33 inhibits c-Myc ubiquitination. 1 / 1
| 1
eidos
"IP experiments showed that USP33 interacted with c-Myc ( Figure 7D ) , and USP33 knockdown profoundly enhanced c-Myc ubiquitination ( Figure 7E ) ."
33718387
USP33 affects c-Myc protein
| 1
USP33 activates c-Myc protein. 1 / 1
| 1
eidos
"USP33 knockdown significantly reduced c-Myc protein expression ( Figure 7B ) , but did not affect c-Myc mRNA expression ( Figure 7C ) ."
33718387
USP33 affects breast cancer cell migration
| 1
USP33 activates breast cancer cell migration. 1 / 1
| 1
eidos
"For instance , USP33 contributes to Slit-mediated breast cancer cell migration [ 49 ] ."
| PMC
USP33 affects beta2AR
| 1
USP33 activates beta2AR. 1 / 1
| 1
reach
"Conversely, depletion of both USP33 and USP20 was shown to increase downregulation of the beta2AR, suggesting a specific role of these DUBs in regulating recycling of this GPCR, in a manner similar to that described for AMSH on the EGFR."
20854416
USP33 affects beta-Arr2
| 1
USP33 binds beta-Arr2. 1 / 1
| 1
reach
"Strikingly, recruitment of USP33 to beta-Arr2 depends on the receptor class, in agreement with previous finding that receptor class determines the kinetics of beta-Arr2 deubiquitylation [XREF_BIBR]."
22988512
USP33 affects autophagy
| 1
USP33 activates autophagy. 1 / 1
| 1
reach
"Mechanistically, we found that DHA degraded RalB, inhibited USP33 expression, and triggered autophagy."
32577124
USP33 affects anti-proliferation miR-206
| 1
USP33 inhibits anti-proliferation miR-206. 1 / 1
| 1
eidos
"These data suggest that the anti-proliferation effects of miR-206 may be mediated by the inhibition of USP33 ."
33718387
USP33 affects ZNRF4
1 |
ZNRF4 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects ZFR
1 |
ZFR binds USP33. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP33 affects YP_009227196
1 |
USP33 binds YP_009227196. 1 / 1
1 |
virhostnet
No evidence text available
30037810
USP33 affects VAPA
1 |
VAPA binds USP33. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects Ubiquitination
| 1
eidos
"Mechanistically , USP33 directly bound SP1 and decreased its ubiquitination , thereby upregulating c-Met expression ."
32835698
USP33 affects Ubiquitin
| 1
Ubiquitin binds USP33. 1 / 1
| 1
isi
"By downregulating candidate deubiquitinases that are either linked with GPCR trafficking or localized on endosomes, we identified signal-transducing adaptor molecule binding protein (STAMBP) and ubiquitin specific protease 33 (USP33) as cognate deubiquitinases for the GCGR."
32967969
USP33 affects USP28
1 |
USP28 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP33 affects USP21
1 |
USP21 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP33 affects USP15
1 |
USP15 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP33 affects USP1
| 1
USP1 binds USP33. 1 / 1
| 1
sparser
"The 2c-biotin probe was found to bind to a number of DUBs, USP1 and USP33 showing a higher affinity compared to USP14, USP18, and UCHL5. xref USP1 and USP33 were reported to be rare proteins, and their contribution to total cellular DUB activity may be limited."
33146523
USP33 affects UBC
1 |
UBC binds USP33. 1 / 1
1 |
biogrid
No evidence text available
24377933
USP33 affects TWIST1
| 1
Modified USP33 decreases the amount of TWIST1. 1 / 1
| 1
reach
"We found that USP33 overexpression can significantly down-regulate the protein level of beta-catenin, snai1, slug, twist1, and N-cadherin, while increasing the E-cadherin expression."
27835898
USP33 affects TRIM63
1 |
TRIM63 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP33 affects TRIM54
1 |
TRIM54 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP33 affects TNF
| 1
USP33 inhibits TNF. 1 / 1
| 1
reach
"Reduced USP33 has been shown to decrease the stability of a suppressor molecule of major proinflammatory gene expression pathways of TNF-α, NF-κB, and IFN-β (22)."
35046947
USP33 affects TLR2
1 |
TLR2 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects TKTL2
1 |
USP33 binds TKTL2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects TGFBR2
| 1
USP33 leads to the deubiquitination of TGFBR2. 1 / 1
| 1
reach
"Mechanistically, USP33 triggered the deubiquitination of TGFBR2 and prevented its degradation by lysosome, therefore promoted TGFBR2 accumulation in cell membrane and eventually contributed to the sustained activation of TGF-β signaling."
37322017
USP33 affects Slit Robo signaling pathway
| 1
USP33 activates Slit Robo signaling pathway. 1 / 1
| 1
eidos
"Downregulation of USP33 inhibits Slit / Robo signaling pathway and is associated with poor patient survival of glioma ."
32972109
USP33 affects SPA17
1 |
SPA17 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP33 affects SCF cyclin
| 1
USP33 inhibits SCF cyclin. 1 / 1
| 1
reach
"USP33 activity antagonizes SCF cyclin F -mediated ubiquitylation and promotes generation of supernumerary centriolar foci, whereas ablation of USP33 destabilizes CP110 and thereby inhibits centrosome amplification and mitotic defects."
23486064
USP33 affects Robo
| 1
USP33 inhibits Robo. 1 / 1
| 1
reach
"Downregulation of USP33 inhibits Slit and Robo signaling pathway and is associated with poor patient survival of glioma."
32972109
USP33 affects ROBO1 receptor
| 1
USP33 inhibits ROBO1 receptor. 1 / 1
| 1
reach
"Similarly, the downregulation of USP33 (a ubiquitin ligase enzyme) reduces the stability of the ROBO1 receptor in lung cancer cells 29 and breast cancer cell migration 30."
33318575
USP33 affects RNApo_II
| 1
USP33 phosphorylates RNApo_II. 1 / 1
| 1
reach
"Some of these proteins include atypical protein kinase C [XREF_BIBR], VHL interacting deubiquitinating enzyme 1 and 2 (VDU 1 and VDU 2) [XREF_BIBR], hyperphosphorylated large subunit (Rpb1) of RNA polymerase II [XREF_BIBR]."
23968328
USP33 affects RB1
| 1
USP33 activates RB1. 1 / 1
| 1
reach
"This study uncovered that USP33 promoted the progression of RB through regulation of the SP1/PI3K/AKT pathway."
34470581
USP33 affects RAB40AL
| 1
USP33 deubiquitinates RAB40AL. 1 / 1
| 1
reach
"It has also been demonstrated that USP33 deubiquitinates RAS like GTPase RALB and therefore promoting autophagosome formation [18]."
28506875
USP33 affects Phosphatase
| 1
USP33 deubiquitinates Phosphatase. 1 / 1
| 1
reach
"USP33 could deubiquitinate PPM1A (protein phosphatase, Mg2 +/Mn2 + dependent 1A), a phosphatase for Smad2/3."
30308513
USP33 activates Pancreatic Neoplasms. 1 / 1
| 1
reach
"Function experiments revealed that USP33 overexpression promoted the proliferation, migration and invasion of PC cells while the inhibition of USP33 expression in PC cells exhibited the opposite effect."
37322017
USP33 affects PRPF38B
1 |
USP33 binds PRPF38B. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP33 affects PPM1A
| 1
USP33 deubiquitinates PPM1A. 1 / 1
| 1
reach
"USP33 could deubiquitinate PPM1A (protein phosphatase, Mg2 +/Mn2 + dependent 1A), a phosphatase for Smad2/3."
30308513
USP33 affects PCGF6
1 |
USP33 binds PCGF6. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects Neoplasms
| 1
USP33 inhibits Neoplasms. 1 / 1
| 1
reach
"Silencing of USP33 disrupted glioma stem cells maintenance, reduced tumor vascularization, and inhibited glioblastoma growth."
35191554
USP33 affects MPPED1
1 |
MPPED1 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP33 affects MAPK
| 1
USP33 inhibits MAPK. 1 / 1
| 1
reach
"Unlike USP33, which has been reported to inhibit mitogen activated protein kinase (MAPK) activation pathway and suppress hepatoma cell growth 26, our study suggests that USP21 activates ERK1/2 to promote HCC cell proliferation."
29706623
USP33 affects LPCAT4
1 |
USP33 binds LPCAT4. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects LDLRAD4
1 |
LDLRAD4 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP33 affects KRR1
1 |
USP33 binds KRR1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP33 affects KO cells
| 1
USP33 activates KO cells. 1 / 1
| 1
eidos
"Knockdown of USP33 suppressed centriole amplification in NudCL2 KO cells ( Fig. 6g-i ) ."
31427565
USP33 affects KITLG
| 1
USP33 inhibits KITLG. 1 / 1
| 1
reach
"CP110 is also regulated by the deubiquitinase USP33, which antagonizes SCF CyclinF activity during S and G2/M to stabilize CP110, causing mitotic abnormalities [XREF_BIBR]."
26432751
USP33 affects ISG75
| 1
USP33 activates ISG75. 1 / 1
| 1
reach
"ISG75 stability is regulated by ubiquitylation [XREF_BIBR] and evidence that trypanosome Usp7 and Vdu1 modulate ISG75 turnover is consistent with this model [XREF_BIBR]."
27614711
USP33 affects IFNB1
| 1
USP33 inhibits IFNB1. 1 / 1
| 1
reach
"Reduced USP33 has been shown to decrease the stability of a suppressor molecule of major proinflammatory gene expression pathways of TNF-α, NF-κB, and IFN-β (22)."
35046947
USP33 affects IFIT5
1 |
IFIT5 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP33 affects HTATIP2
| 1
ROBO1 binds HTATIP2 and USP33. 1 / 1
| 1
sparser
"Co-immunoprecipitation using deletion mutants of Robo1 and USP33 showed that the Robo1 CC3 motif interacted with USP33 in the region containing the catalytic USP and substrate-recognizing DUSP domains xref ( xref )."
19684588
USP33 affects HIF1A
| 1
USP33 deubiquitinates HIF1A. 1 / 1
| 1
reach
"In addition, VDU2, but not VDU1, is able to interact with and deubiquitinate HIF1alpha, and rescue it from proteasome mediated degradation."
25605410
USP33 affects HDAC2
| 1
USP33 activates HDAC2. 1 / 1
| 1
reach
"Whilst USP33 or USPL1 depletion increased the HDAC2 and HDAC1 ratio, we identified USP27X and the tumor suppressor BAP1 as DUBs whose depletion lead to the most significant decrease in the HDAC2 and HDAC1 ratio."
25970771
USP33 affects HDAC1
| 1
USP33 activates HDAC1. 1 / 1
| 1
reach
"Whilst USP33 or USPL1 depletion increased the HDAC2 and HDAC1 ratio, we identified USP27X and the tumor suppressor BAP1 as DUBs whose depletion lead to the most significant decrease in the HDAC2 and HDAC1 ratio."
25970771
USP33 affects Glioma
| 1
USP33 activates Glioma. 1 / 1
| 1
reach
"Silencing of USP33 disrupted glioma stem cells maintenance, reduced tumor vascularization, and inhibited glioblastoma growth."
35191554
USP33 affects Glioblastoma
| 1
USP33 inhibits Glioblastoma. 1 / 1
| 1
reach
"Silencing of USP33 disrupted glioma stem cells maintenance, reduced tumor vascularization, and inhibited glioblastoma growth."
35191554
USP33 affects GNAI3
1 |
USP33 binds GNAI3. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP33 affects FH
| 1
BTRC binds USP33 and FH. 1 / 1
| 1
sparser
"Β-TrCP can also interact with FH-USP33(△DSG) ( Fig. 3 B ), indicating that the interaction between β-TrCP and USP33 is independent of DSG motif of USP33."
28506875
USP33 affects FBXL5
| 1
FBXL5 binds USP33 and HERC2. 1 / 1
| 1
sparser
"More recently, HERC2 was shown to interact with p53 through the p53 tetramerization domain, thus affecting p53 oligomerization and downstream transcriptional activity. xref HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin-mediated proteasomal degradation. xref , xref HERC2 has also been shown to regulate centrosome morphology and ubiquitin ligase activity through interactions with NEURL4 and UBE3A (also known as E6AP), respectively."
25476789
USP33 affects EXOC2
1 |
USP33 binds EXOC2. 1 / 1
1 |
biogrid
No evidence text available
24056301
USP33 affects ERK
| 1
USP33 activates ERK. 1 / 1
| 1
reach
"Interestingly, our results demonstrated that USP33 knock-down can significantly increase the " late " ERK activation induced by SDF- 1."
27835898
USP33 affects ELAVL1
1 |
USP33 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
19322201
USP33 affects E7BBT6
1 |
USP33 binds E7BBT6. 1 / 1
1 |
virhostnet
No evidence text available
28786561
USP33 affects Cyclin
| 1
USP33 inhibits Cyclin. 1 / 1
| 1
reach
"In this study, USP33 knockdown was achieved as a proof-of-concept because USP33 can antagonize cyclin F actions on CP110 in regulating centrosome duplication, maturation and separation."
26304236
USP33 affects CNTLN
| 1
USP33 deubiquitinates CNTLN. 1 / 1
| 1
reach
"For example, USP33 deubiquitylates the centrosomal protein CP110, regulating centrosome biogenesis [76] and USP33 depletion has a co-operative effect with CDK2 on the CP110-dependent clustering function mentioned earlier [77]."
31506331
USP33 affects CDH2
| 1
Modified USP33 decreases the amount of CDH2. 1 / 1
| 1
reach
"We found that USP33 overexpression can significantly down-regulate the protein level of beta-catenin, snai1, slug, twist1, and N-cadherin, while increasing the E-cadherin expression."
27835898
USP33 affects BECN1
1 |
BECN1 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
24056301
USP33 affects AVPR2
| 1
USP33 inhibits AVPR2. 1 / 1
| 1
reach
"While USP33 overexpression blocked the cointernalization of beta-arrestin with activated V 2 R on endosomes and curtailed ERK activation mediated by beta-arrestin, knockdown of endogenously expressed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24377933
USP33 affects ARs
| 1
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
USP33 affects APBA2
1 |
USP33 binds APBA2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP33 affects 7TMR
| 1
ARRB binds USP33 and 7TMR. 1 / 1
| 1
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968
USP28 affects USP33
1 |
USP28 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP21 affects USP33
1 |
USP21 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP20 affects ARs
| 1
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
USP20 affects AR
| 1
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
USP15 affects USP33
1 |
USP15 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
USP1 affects USP33
| 1
USP1 binds USP33. 1 / 1
| 1
sparser
"The 2c-biotin probe was found to bind to a number of DUBs, USP1 and USP33 showing a higher affinity compared to USP14, USP18, and UCHL5. xref USP1 and USP33 were reported to be rare proteins, and their contribution to total cellular DUB activity may be limited."
33146523
UBC affects USP33
1 |
UBC binds USP33. 1 / 1
1 |
biogrid
No evidence text available
24377933
TRIM63 affects USP33
1 |
TRIM63 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
TRIM54 affects USP33
1 |
TRIM54 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
22626734
TLR2 affects USP33
1 |
TLR2 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
28514442
TKTL2 affects USP33
1 |
USP33 binds TKTL2. 1 / 1
1 |
biogrid
No evidence text available
28514442
TGFB affects USP33
| 1
TGFB increases the amount of USP33. 1 / 1
| 1
reach
"Moreover, our results revealed that the activation of TGF-β targeted gene ZEB1 promoted the transcription of USP33."
37322017
Slit2-Robo1 affects USP33
| 1
Slit2-Robo1 inhibits USP33. 1 / 1
| 1
reach
"The inhibitory function of Slit2-Robo1 is mediated by ubiquitin specific protease 33 (USP33) via deubiquitinating and stabilizing Robo1."
30896071
SRGAP1 affects ROBO1
| 1
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
SPA17 affects USP33
1 |
SPA17 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
26186194
ROBO1 affects SRGAP1
| 1
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
ROBO1 affects HTATIP2
| 1
ROBO1 binds HTATIP2 and USP33. 1 / 1
| 1
sparser
"Co-immunoprecipitation using deletion mutants of Robo1 and USP33 showed that the Robo1 CC3 motif interacted with USP33 in the region containing the catalytic USP and substrate-recognizing DUSP domains xref ( xref )."
19684588
Protease affects USP33
| 1
Protease activates USP33. 1 / 1
| 1
reach
"The inhibitory function of Slit2-Robo1 is mediated by ubiquitin specific protease 33 (USP33) via deubiquitinating and stabilizing Robo1."
30896071
Plant Extracts affects USP33
1 |
Plant Extracts increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
23557933
PRPF38B affects USP33
1 |
USP33 binds PRPF38B. 1 / 1
1 |
biogrid
No evidence text available
19615732
PFKFB3 affects USP33
| 1
USP33 binds PFKFB3. 1 / 1
| 1
sparser
"Collectively, these findings reveal a mechanism by which OS cells survive in a dystrophic tumor microenvironment, with the USP33-PFKFB3 axis as a critical driver of aerobic glycolysis and OS proliferation."
37034227
PCGF6 affects USP33
1 |
USP33 binds PCGF6. 1 / 1
1 |
biogrid
No evidence text available
28514442
NudCL2 KO affects USP33
| 1
NudCL2 KO inhibits USP33. 1 / 1
| 1
eidos
"Further analyses showed that NudCL2 KO decreased the degradation of USP33 ( Supplementary Fig. 5 ) ."
31427565
Norepinephrine affects USP33
1 |
Norepinephrine increases the amount of USP33. 1 / 1
1 |
bel
"VDU1, but not VDU2, is markedly increased in brown adipocytes by norepinephrine or cold exposure, further amplifying the increase in D2 activity that results from catecholamine-stimulated de novo synthesis."
12865408
reach
"Our results showed that MG132 blocked beta-TrCP-mediated USP33 downregulation, suggesting that beta-TrCP promotes USP33 downregulation via the proteasome pathway."
28506875
MPPED1 affects USP33
1 |
MPPED1 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
26186194
MIR148A affects USP33
| 1
MIR148A inhibits USP33. 1 / 1
| 1
eidos
"MiR-590 can directly target IRF9 while miR-148a suppresses USP33 expression levels in human microglia ."
| PMC
LPCAT4 affects USP33
1 |
USP33 binds LPCAT4. 1 / 1
1 |
biogrid
No evidence text available
28514442
LDLRAD4 affects USP33
1 |
LDLRAD4 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
26186194
KRR1 affects USP33
1 |
USP33 binds KRR1. 1 / 1
1 |
biogrid
No evidence text available
19615732
JNK affects DUSP1
| 1
JNK binds USP33 and DUSP1. 1 / 1
| 1
sparser
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
IL6 affects USP33
| 1
IL6 increases the amount of USP33. 1 / 1
| 1
reach
"IL-6 stimulation of the cells obviously enhanced the expression of USP33."
30187867
IFIT5 affects USP33
1 |
IFIT5 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
19615732
ID2 affects USP33
| 1
USP33 binds ID2. 1 / 1
| 1
reach
"USP33 binding ID2 may have precluded ID2 recognition by the proteasome and prevented its degradation."
21925315
HTATIP2 affects USP33
| 1
ROBO1 binds HTATIP2 and USP33. 1 / 1
| 1
sparser
"Co-immunoprecipitation using deletion mutants of Robo1 and USP33 showed that the Robo1 CC3 motif interacted with USP33 in the region containing the catalytic USP and substrate-recognizing DUSP domains xref ( xref )."
19684588
HERC2 affects FBXL5
| 1
FBXL5 binds USP33 and HERC2. 1 / 1
| 1
sparser
"More recently, HERC2 was shown to interact with p53 through the p53 tetramerization domain, thus affecting p53 oligomerization and downstream transcriptional activity. xref HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin-mediated proteasomal degradation. xref , xref HERC2 has also been shown to regulate centrosome morphology and ubiquitin ligase activity through interactions with NEURL4 and UBE3A (also known as E6AP), respectively."
25476789
GNAI3 affects USP33
1 |
USP33 binds GNAI3. 1 / 1
1 |
biogrid
No evidence text available
26186194
FH affects USP33
| 1
BTRC binds USP33 and FH. 1 / 1
| 1
sparser
"Β-TrCP can also interact with FH-USP33(△DSG) ( Fig. 3 B ), indicating that the interaction between β-TrCP and USP33 is independent of DSG motif of USP33."
28506875
FBXL5 affects USP33
| 1
FBXL5 binds USP33 and HERC2. 1 / 1
| 1
sparser
"More recently, HERC2 was shown to interact with p53 through the p53 tetramerization domain, thus affecting p53 oligomerization and downstream transcriptional activity. xref HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin-mediated proteasomal degradation. xref , xref HERC2 has also been shown to regulate centrosome morphology and ubiquitin ligase activity through interactions with NEURL4 and UBE3A (also known as E6AP), respectively."
25476789
EXOC2 affects USP33
1 |
USP33 binds EXOC2. 1 / 1
1 |
biogrid
No evidence text available
24056301
EPAS1 affects USP33
| 1
USP33 binds EPAS1. 1 / 1
| 1
sparser
"USP33 is preferentially induced in glioma stem cells by hypoxia and interacts with HIF-2alpha, leading to its stabilization through deubiquitination."
35191554
ELOC affects VHL
1 |
ELOC binds ELOB, VHL, and USP33. 1 / 1
1 |
hprd
No evidence text available
11739384
ELAVL1 affects USP33
1 |
USP33 binds ELAVL1. 1 / 1
1 |
biogrid
No evidence text available
19322201
E7BBT6 affects USP33
1 |
USP33 binds E7BBT6. 1 / 1
1 |
virhostnet
No evidence text available
28786561
DUSP1 affects JNK, and USP33
| 1
JNK binds USP33 and DUSP1. 1 / 1
| 1
sparser
"Furthermore, we found that USP33 could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while USP33 knockdown promoted the proteasomal degradation of DUSP1."
31857702
Class A receptor affects USP33
| 1
Class A receptor activates USP33. 1 / 1
| 1
reach
"The association of USP33 and beta-arrestin 2 itself appears to be dependent on the class of 7TMR as activation of the beta2-adrenergic receptor (beta2AR), a Class A receptor known to have a transient interaction with beta-arrestins, enhances the association of beta-arrestin 2 with USP33 [XREF_BIBR]."
21476968
CRC affects SRGAP1
| 1
ROBO1 binds SRGAP1, USP33, and CRC. 1 / 1
| 1
sparser
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
CCP110 affects USP20, and USP33
| 1
USP20 binds USP33 and CCP110. 1 / 1
| 1
sparser
"Since USP33 and USP20 interact with CP110 at centrosomes, and CP110 protein levels correlated with USP33 and USP20 during the cell cycle, we investigated whether USP33 or USP20 might stabilize CP110."
23486064
BTRC affects infC
| 1
BTRC binds USP33 and infC. 1 / 1
| 1
sparser
"Therefore, USP33 isoform 3 is suitable for the analysis of interaction between β-TrCP and USP33-DSG motif."
28506875
BTRC affects FH, and USP33
| 1
BTRC binds USP33 and FH. 1 / 1
| 1
sparser
"Β-TrCP can also interact with FH-USP33(△DSG) ( Fig. 3 B ), indicating that the interaction between β-TrCP and USP33 is independent of DSG motif of USP33."
28506875
BECN1 affects USP33
1 |
BECN1 binds USP33. 1 / 1
1 |
biogrid
No evidence text available
24056301
BAAT affects USP33
| 1
BAAT increases the amount of USP33. 1 / 1
| 1
reach
"Interestingly, cold exposure of BAT rapidly induces transcription of ER localized VDU1 deubiquitinase which is capable of deubiquitinating and stabilizing ectopic D2 but not D1, signifying that the sparing of D2 from ER localized degradation is physiologically relevant."
27743014
Arrestins affects USP33
| 1
Arrestins deubiquitinates USP33. 1 / 1
| 1
reach
"Arrestins also recruit deubiquitinating enzymes USP33 and USP20, important for recycling and resensitisation to the beta2-adrenergic receptor."
20412604
Aroclor 1254 affects USP33
1 |
Aroclor 1254 decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
23650126
ATF3 affects USP33
| 1
USP33 binds ATF3. 1 / 1
| 1
sparser
"Dengue Virus Degrades USP33-ATF3 Axis via Extracellular Vesicles to Activate Human Microglial Cells."
32848034
ARs affects USP33
| 1
USP20 binds USP33 and ARs. 1 / 1
| 1
sparser
"Plasma membrane-localized β 2 ARs can bind to two closely related DUBs, USP33 and USP20 (also known as VDU2)."
23764054
ARRB2 affects AR
| 1
USP33 binds AR and ARRB2. 1 / 1
| 1
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
ARRB affects 7TMR
| 1
ARRB binds USP33 and 7TMR. 1 / 1
| 1
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968
AR affects USP20, and USP33
| 1
USP20 binds USP33 and AR. 1 / 1
| 1
sparser
"Because carvedilol enhanced β 2 AR ubiquitination and degradation independently of the known β 2 AR E3 ligase Nedd4, we reasoned that carvedilol might diminish β 2 AR deubiquitination by reducing the association of the β 2 AR with USP20 and/or USP33."
23166351
AR affects ARRB2, and USP33
| 1
USP33 binds AR and ARRB2. 1 / 1
| 1
sparser
"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
23764054
APBA2 affects USP33
1 |
USP33 binds APBA2. 1 / 1
1 |
biogrid
No evidence text available
28514442
ADRB2 affects USP33
1 |
USP33 binds ADRB2. 1 / 1
1 |
biogrid
No evidence text available
23166351
AD-VDU1 f affects USP33
| 1
AD-VDU1 f activates USP33. 1 / 1
| 1
reach
"The reporter gene was activated only when AD-VDU1 f was co-transformed with BD-hSP56, supporting the specificity of the hSP56 and VDU1 f interaction.We then expressed and purified VDU1 f from E. coli [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19118533
7TMR affects USP33
| 1
ARRB binds USP33 and 7TMR. 1 / 1
| 1
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968
3-isobutyl-1-methyl-7H-xanthine increases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
28628672
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
21215274
(R)-noradrenaline affects USP33
| 1
reach
"VDU1, but not VDU2, is markedly increased in brown adipocytes by norepinephrine or cold exposure, further amplifying the increase in D2 activity that results from catecholamine stimulated de novo synthesis."
12865408
(+)-JQ1 compound affects USP33
1 |
(+)-JQ1 compound decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
23086925
2,2',3',4,4',5-hexachlorobiphenyl decreases the amount of USP33. 1 / 1
1 |
ctd
No evidence text available
23829299