IndraLab

Statements

ARRB binds USP33. 7 / 7
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"Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors."
19363159
sparser
"The association of USP33 and β-arrestin 2 itself appears to be dependent on the class of 7TMR as activation of the β2-adrenergic receptor (β2AR), a Class A receptor known to have a transient interaction with β-arrestins, enhances the association of β-arrestin 2 with USP33 [ xref ]."
21476968
sparser
"Specific conformations of β-arrestins induced by different 7TMR binding can also determine the kinetics and stability of interaction of β-arrestin with the deubiquitinating enzyme USP33 [ xref ]."
21680031
sparser
"Conversely, stimulation of the vasopressin V2R, a Class B receptor known to have prolonged interaction with β-arrestins, does not enhance β-arrestin 2-USP33 interaction."
21476968
sparser
"These DUBs are constitutively bound to the cell-surface β 2 ARs; however, β 2 AR–USP association decreases upon agonist activation, while simultaneously agonist stimulation leads to the recruitment of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23764054
sparser
"The detailed steps to assay the kinetics of β-arrestin–USP33 interaction are described later."
24377933
sparser
"Further, the association of the deubiquitinase USP33 with β-arrestin 2 was shown to regulate 7TMR-β-arrestin 2 interaction with greater USP33-β-arrestin 2 association resulting in decreased 7TMR-β-arrestin 2 interaction and loss of localized intracellular signaling [ xref ]."
21476968