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USP33 activates Neoplasm Metastasis. 18 / 18
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"For example, a recent study revealed that enhanced USP33 expression was associated with reduced survival rates in OC patients; mechanistically, USP33 promotes OC cell growth and metastasis via deubiquitinating and stabilizing CBX2 (Chen et al. 2024)."
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"Functionally, our experiments demonstrate that USP33 significantly enhances ovarian cancer proliferation and metastasis in a CBX2-dependent manner."
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"In conclusion, our study found that USP33 contributed to the proliferation and metastasis of pancreatic cancer through a positive feedback loop with TGF-beta signaling pathway."
37322017
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"USP33 is an integrin alpha6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis."
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"For example, in hepatocellular carcinoma (HCC), the deubiquitinase USP33 stabilizes Sp1, leading to increased c-Met expression and enhanced HCC metastasis (29)."
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"We found that USP33 knockdown inhibited the invasion and metastasis in HCC cells both in vitro and in vivo, which was partly dependent on c-Met."
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"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 and c-Met axis."
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"USP33/TGFBR2 axis promoted the tumor growth and metastasis of PC in vivo."
37322017
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"The overexpression of USP33 accelerated the proliferation, invasion and metastasis of PC in vitro and in vivo."
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"Additionally, results from in vivo and in vitro studies showed that USP33 knockdown inhibits invasion, migration, and metastasis in HCC cells."
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"Secondly, the details of mechanisms by which USP33 promotes GAC growth and metastasis are still unclear; for example, the effects of USP33 on cell viability may be caused by either suppressing proliferation or enhancing apoptosis."
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"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 / c-Met axis ."
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"Altogether, these findings demonstrate that integrin α6 plays a critical role in USP33-mediated ESCC cell metastasis."
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"Moreover, we demonstrated that USP33 could mediate ESCC cell migration and metastasis through integrin α6."
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"The results showed that knockdown of USP33 inhibited the liver metastasis of PC and increased the OS of PC bearing nude mice, while the overexpression of TGFBR2 remedied this phenotype (Fig. 8D–F)."
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"Taking together, our results demonstrated that USP33 promoted the tumor growth and metastasis of PC in a TGFBR2-dependent manner."
37322017
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"USP33 knockdown could inhibit ESCC cell migration and metastasis majorly through integrin alpha6."
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"In our research, we reported for the first time that USP33 mediated the proliferation and metastasis of pancreatic cancer through its deubiquitinating function which may provide a novel explanation for PC malignant development.USP33 was a member of the ubiquitin-specific protease (USP) family which was the largest deubiquitination enzymes (DUBs) family."
37322017