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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

FBXL5 binds USP33 and HERC2. 1 / 1

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"More recently, HERC2 was shown to interact with p53 through the p53 tetramerization domain, thus affecting p53 oligomerization and downstream transcriptional activity. xref HERC2 also interacts with the deubiquitinating enzyme USP33 and the SCF protein FBXL5, regulating their stability through ubiquitin-mediated proteasomal degradation. xref , xref HERC2 has also been shown to regulate centrosome morphology and ubiquitin ligase activity through interactions with NEURL4 and UBE3A (also known as E6AP), respectively."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...