IndraLab

"To better understand the consequences of mtDNA deletions, we microarrayed six cell types containing mtDNA deletions from KSS and CPEO patients. Indicated are transcripts shared and downregulated in cells harboring mtDNA deletions in >3 experiments (Table 4); Differentially expressed genes were identified by comparing GeneChips designated as baseline (muscles, myoblasts, fibroblasts, and lymphoblasts from healthy subjects, fusion control cell lines, and parental 143B cells) with the ones that represent the experimental parameters (muscles, myoblasts, fibroblasts, and lymphoblasts from patients, mutant cybrids, and 143B rho zero cells) using a difference in mean fluorescence ? 30 and a P value < 0.05; 37 downregulated genes; 26 upregulated genes;"