IndraLab

Statements

MiR-365a-3p activates USP33. 7 / 7
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"Functional rescue assays demonstrated that miR-365a-3p promoted proliferation, migration, and invasion by downregulating USP33."
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"This further suggested that miR-365a-3p promotes the proliferation of lung cancer cells by downregulating USP33."
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"The above series of in vitro experiments suggested that miR-365a-3p promotes lung cancer progression by downregulating USP33; however, the signalling pathways involved in this process remain unknown."
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"This is the first evidence for a lung cancer invasion and metastasis mechanism in which miR-365a-3p directly targets and downregulates USP33, which further promotes the proliferation, migration, and invasion activities of lung cancer."
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"MiR-365a-3p enhance the migration and invasion of lung cancer cells by inhibiting ubiquitin specific peptidase 33 (USP33)/ slit guidance ligand 2 (SLIT2)/ roundabout guidance Receptor 1 (ROBO1) signaling pathway (101)."
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"This suggested that miR-365a-3p directly targets and binds the USP33 3 ' UTR."
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"To further verify that miR-365a-3p directly targets and downregulates USP33, the wild-type 3 ' UTR of USP33 (WT USP33 3 ' UTR) or a mutated USP33 3 ' UTR (Mut USP33 3 ' UTR) was cloned into a dual-luciferase UTR vector and then co-transfected with agomiR-365 or a negative control (agomiR-NC) into A549 and SPC-A-1 cells."
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