IndraLab

Statements


USP33 activates CCP110. 4 / 8
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"Further, USP33 suppression significantly reduced CP110 protein half-life from ~ 4.5 hours to ~ 2 hours (XREF_SUPPLEMENTARY)."

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"USP33 promotes the generation of excessive centriolar foci due to elevated levels of CP110 because (1) over-expression of human or murine USP33 led to CP110 up-regulation in multiple cell lines (XREF_SUPPLEMENTARY) and (2) depletion of CP110 overrode USP33 mediated generation of centriolar foci (XREF_SUPPLEMENTARY)."

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"We observed that USP33 depletion did not lead to a reduction in RRM2 levels (XREF_SUPPLEMENTARY), indicating that USP33 specifically stabilizes CP110."

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"Further, depletion of USP33 in two PDAC cell lines (Panc1 and MiaPaCa2) led to a reduction in CP110 levels (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY), indicating that USP33 stabilizes CP110 in PDAC cells."