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USP33 activates Neoplasm Invasiveness. 19 / 19
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"USP33 promoted the proliferation, migration and invasion of PC cells."
37322017
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"As shown in Fig. 3A, compared with other ECM components, the binding ability of USP33-overexpressed cells was significantly increased in the laminin (which is also the primary component of Matrigel) group, indicating that USP33-mediated invasion may be related to the inducement of the adhesiveness to laminin."
39589547
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"USP33 promotes cell invasion, but not growth and migration, in normal cell culture conditions."
39589547
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"Next, functional rescue assays were performed to further verify that the miR-365a-3p-mediated downregulation of USP33 promotes the proliferation, migration, and invasion of lung cancer cells."
29743814
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"As expected, knockdown of USP33 only attenuated KYSE-150 cell invasion (Fig. 2F)."
39589547
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"Together, our results indicate that USP33 can promote cell invasion but has no remarkable effect on cell proliferation and migration in normal cell culture conditions."
39589547
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"Since cell-matrix adhesion is closely correlated with cell migration and invasive potentials in tumors (Hamidi and Ivaska 2018; Chastney et al. 2024), we wondered whether USP33-mediated invasion is specific ECM component(s) dependent."
39589547
eidos
"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 / c-Met axis ."
32835698
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"This is the first evidence for a lung cancer invasion and metastasis mechanism in which miR-365a-3p directly targets and downregulates USP33, which further promotes the proliferation, migration, and invasion activities of lung cancer."
29743814
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"Through our function experiments, we found that USP33 promoted the proliferation, migration and invasion of PC in vitro and in vivo."
37322017
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"Additionally, results from in vivo and in vitro studies showed that USP33 knockdown inhibits invasion, migration, and metastasis in HCC cells."
35924961
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"The overexpression of USP33 accelerated the proliferation, invasion and metastasis of PC in vitro and in vivo."
37322017
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"Moreover, overexpression of USP33 Cys : His can slightly promote cell proliferation and invasion (XREF_SUPPLEMENTARY), instead of the inhibiting effects caused by USP33 wild type."
27835898
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"To assess whether USP33 affected the invasiveness and migration of PC cells, we performed the transwell migration and invasion assays and found that USP33 knockdown significantly inhibited the migration and invasiveness of PC cells while USP33 overexpression showed the opposite effect (Fig. 2H–J)."
37322017
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"Further western-blotting experiment demonstrated that USP33 knockdown inhibited the expression of biomarkers of migration and invasion while TGFBR2 overexpression rescued its effect (Fig. 4J)."
37322017
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"We found that USP33 knockdown inhibited the invasion and metastasis in HCC cells both in vitro and in vivo, which was partly dependent on c-Met."
32835698
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"Our results reveal that USP33 acts as the deubiquitinating enzyme of SP1 and contributes to HCC invasion and metastasis through activation of the SP1 and c-Met axis."
32835698
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"On the other hand, USP33 knock-down promoted cell proliferation and invasion under SDF-1 stimulation; whereas dynasore (an internalization inhibitor) pretreatment in USP33 silencing cells showed a distinct antipromoting effect, revealing the participation of CXCR4 internalization in regulating tumor progress."
27835898
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"Function experiments revealed that USP33 overexpression promoted the proliferation, migration and invasion of PC cells while the inhibition of USP33 expression in PC cells exhibited the opposite effect."
37322017