IndraLab

Statements

ROBO1 binds USP33. 29 / 32
3 | 11 15
biogrid
No evidence text available
19684588
reach
"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
sparser
"In lung cancer cells, USP33 interacted with Robo1, similar to the observation in the breast cancer cells, as detected by co-immunoprecipitation experiments (Fig.  xref A)."
24981056
sparser
"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells xref , xref ."
25242263
sparser
"The mechanism of the interaction between Robo1 and USP33 was explored by co-IP and ubiquitination protein analysis."
30896071
reach
"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells XREF_BIBR, XREF_BIBR."
25242263
reach
"USP33 interacts with Robo1 and mediates Slit2 signaling in CRC cells."
25242263
sparser
"USP33 interacts with the axonal guidance receptor Roundabout (Robo) 1 [ xref ], whose ligand is Slit."
21704388
reach
"The mechanism of the interaction between Robo1 and USP33 was explored by co-IP and ubiquitination protein analysis."
30896071
biogrid
No evidence text available
19706539
reach
"These results show that Robo1 interacts with USP33 in CRC cells."
25242263
reach
"This positive-feedback loop, which stimulates the mobilization of stored Robo receptors to the cell surface, depends on interaction between Robo1 and the DUb USP33."
21955996
sparser
"Robo1-USP33 interaction was confirmed in transfected cells and in embryonic neurons."
19684588
sparser
"To test the specificity of Robo1-USP33 interaction, we examined whether Robo1 was co-immunoprecipitated with USP20, a homolog sharing similar domain organization and 59% amino acid identity with USP33 xref ."
19684588
sparser
"In summary, our experiments demonstrate that USP33 interacts with the intracellular domain of Robo1 and that USP33 is required for Slit responsiveness of commissural neurons."
19684588
sparser
"These results show that Robo1 interacts with USP33 in CRC cells."
25242263
sparser
"Our current work shows that in lung cancer cells, USP33 also interacts with Robo1 and is required for Slit signaling in inhibiting lung cancer cell migration."
24981056
reach
"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
27923383
reach
"However, in our previous study, USP33 interacts with Robo1 and is required for Slit induced Robo1 redistribution to the plasma membrane without affecting the total Robo1 protein level."
24981056
reach
"In lung cancer cells, USP33 interacted with Robo1, similar to the observation in the breast cancer cells, as detected by co-immunoprecipitation experiments."
24981056
sparser
"Slit treatment did not affect Robo1-USP33 interaction."
19684588
sparser
"USP33 interacts with Robo1 and mediates Slit2 signaling in CRC cells."
25242263
sparser
"USP33 is associated with the axonal guidance receptor Roundabout (Robo) 1 ( xref ), which plays a major role in controlling axon crossing across the midline between brain hemispheres and neuronal dendrites ( xref )."
32133826
sparser
"Moreover, the interaction between USP33 and Robo1 protein was identified, and knockdown of Robo1 enhancing the oncogenic effect upon USP33-knockdown, suggesting that USP33 may inhibit tumor progression through Robo1 signaling."
29533940
sparser
"However, in our previous study, USP33 interacts with Robo1 and is required for Slit-induced Robo1 redistribution to the plasma membrane without affecting the total Robo1 protein level."
24981056
biogrid
No evidence text available
19706539
reach
"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
25242263
reach
"Our current work shows that in lung cancer cells, USP33 also interacts with Robo1 and is required for Slit signaling in inhibiting lung cancer cell migration."
24981056
sparser
"We confirmed that the endogenously expressed Robo1 and USP33 interacted with each other in the mouse brain ( xref )."
19684588