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ROBO1 binds USP33. 25 / 34
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"These results confirmed that Robo1 could interact with srGAP1 and USP33 in CRC cells, and srGAP1 could not interact with USP33 directly."
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"Robo1-USP33 interaction was confirmed in transfected cells and in embryonic neurons."
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"Slit treatment did not affect Robo1-USP33 interaction."
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"To test the specificity of Robo1-USP33 interaction, we examined whether Robo1 was co-immunoprecipitated with USP20, a homolog sharing similar domain organization and 59% amino acid identity with USP33 xref ."
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"We confirmed that the endogenously expressed Robo1 and USP33 interacted with each other in the mouse brain ( xref )."
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"In summary, our experiments demonstrate that USP33 interacts with the intracellular domain of Robo1 and that USP33 is required for Slit responsiveness of commissural neurons."
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"USP33 is associated with the axonal guidance receptor Roundabout (Robo) 1 ( xref ), which plays a major role in controlling axon crossing across the midline between brain hemispheres and neuronal dendrites ( xref )."
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"USP33 interacts with Robo1 and mediates Slit2 signaling in CRC cells."
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"Ubiquitin-specific protease 33 (USP33)/VDU1 was also shown to be involved in ROBO1–USP33 interaction and participate in SLIT/ROBO signaling in cancer cell migration. xref Another study also showed that srGAP1 is an important downstream molecule of Slit2 signaling in CRC, and mediates the antimigration function of Slit2 by inhibiting Cdc42. xref SrGAP2 protein expression is reduced or absent in a subset of primary osteosarcoma samples, srGAP2 and other axon guidance proteins likely play a role in osteosarcoma metastasis. xref "
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"Our current work shows that in lung cancer cells, USP33 also interacts with Robo1 and is required for Slit signaling in inhibiting lung cancer cell migration."
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"However, in our previous study, USP33 interacts with Robo1 and is required for Slit-induced Robo1 redistribution to the plasma membrane without affecting the total Robo1 protein level."
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"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells xref , xref ."
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"These results show that Robo1 interacts with USP33 in CRC cells."
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"In lung cancer cells, USP33 interacted with Robo1, similar to the observation in the breast cancer cells, as detected by co-immunoprecipitation experiments (Fig.  xref A)."
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"This positive-feedback loop, which stimulates the mobilization of stored Robo receptors to the cell surface, depends on interaction between Robo1 and the DUb USP33."
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"Moreover, the interaction between USP33 and Robo1 protein was identified, and knockdown of Robo1 enhancing the oncogenic effect upon USP33-knockdown, suggesting that USP33 may inhibit tumor progression through Robo1 signaling."
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"In lung cancer cells, USP33 interacted with Robo1, similar to the observation in the breast cancer cells, as detected by co-immunoprecipitation experiments."
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"USP33 interacts with the axonal guidance receptor Roundabout (Robo) 1 [ xref ], whose ligand is Slit."
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"Our current work shows that in lung cancer cells, USP33 also interacts with Robo1 and is required for Slit signaling in inhibiting lung cancer cell migration."
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"However, in our previous study, USP33 interacts with Robo1 and is required for Slit induced Robo1 redistribution to the plasma membrane without affecting the total Robo1 protein level."
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"USP33 interacts with Robo1 and mediates Slit2 signaling in CRC cells."
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"Our previous studies have shown that USP33 interacts with Robo1 in neurons and breast cancer cells XREF_BIBR, XREF_BIBR."
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"To test the interaction between Robo1 and USP33 in CRC cells, we performed co-IP assays."
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"These results show that Robo1 interacts with USP33 in CRC cells."
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"In CRC cells, USP33 interacts with Robo1 and mediates the inhibitory activity of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
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