IndraLab

Statements

USP33 binds SP1. 4 / 4
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"Intriguingly, the results indicated that endogenous USP33 and SP1 are directly bound in HCC cells ( Fig. 5 C and Supplemental Fig. 7A)."
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"Mechanistically, USP33 directly bound SP1 and decreased its ubiquitination, thereby upregulating c-Met expression."
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"Mechanistically, USP33 directly bound SP1 protein and decrease its ubiquitination and enhance its protein stability, thereby upregulating c-Met expression which eventually promoted the migration and invasion of HCC [40]."
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"To this end, we first performed Co-IP experiments to detect the interaction between USP33 and SP1 proteins in HCC cells."
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