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USP33 deubiquitinates PRKN on K435. 2 / 2

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"Different from USP30 which regulates substrates of Parkin, USP33 can directly and selectively deubiquitinate Parkin at Lys435 and preferentially remove K6, K11, K48, and K63-linked ubiquitin conjugates from Parkin."

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"USP33 prefers to remove K6, K11, K48 and K63 linked ubiquitin conjugates from PRKN, and deubiquitinates PRKN mainly at Lys435."

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INDRA sources:

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IndraLab

Statements

USP33 deubiquitinates PRKN on K435. 2 / 2

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