IndraLab

Statements

IRF9 binds USP33. 6 / 6
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"Disruption of the USP33-IRF9 axis stimulates the noncanonical activation of pro-inflammatory genes from microglia and leads to severe neuroinflammation in the central nervous system (CNS)."
36593971
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"Collectively, SARS-CoV-2 not only regulates the levels of circulating miRNAs activating cytokines, but also mediates the alternative pathways of CNS injury by inhibiting the USP33-IRF9 axis."
36593971
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"Therefore, the hyperactivation of the USP33-IRF9 axis regulated by exosomal miRNA in human microglia uncovers a bystander pathway of SARS-CoV-2-mediated CNS damage."
36977948
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"They also deregulated the USP33-IRF9 network following their internalization in human microglia cells."
36077138
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"Disruption of USP33-IRF9 axis stimulate the non-canonical activation of pro-inflammatory genes from microglia and lead to severe neuroinflammation inside CNS ( xref )."
33936086
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"Mishra, R. and Banerjea, A. C., SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia."
| DOI