IndraLab

Statements

reach
"Function experiments revealed that USP33 overexpression promoted the proliferation, migration and invasion of PC cells while the inhibition of USP33 expression in PC cells exhibited the opposite effect."
37322017
reach
"In conclusion, our study found that USP33 contributed to the proliferation and metastasis of pancreatic cancer through a positive feedback loop with TGF-beta signaling pathway."
37322017
reach
"Next, functional rescue assays were performed to further verify that the miR-365a-3p-mediated downregulation of USP33 promotes the proliferation, migration, and invasion of lung cancer cells."
29743814
reach
"Functionally, our experiments demonstrate that USP33 significantly enhances ovarian cancer proliferation and metastasis in a CBX2-dependent manner."
39256572
reach
"Additionally, we confirmed that 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) was critical for USP33-induced proliferation and aerobic glycolysis in OS cells, and the protein expression levels of PFKFB3 and USP33 were positively correlated in the OS tissues."
37034227
reach
"Through our function experiments, we found that USP33 promoted the proliferation, migration and invasion of PC in vitro and in vivo."
37322017
reach
"Previous studies showed that USP33 promotes cell proliferation and reduces apoptosis in retinoblastoma [ 36 ]."
37267862
reach
"The overexpression of USP33 accelerated the proliferation, invasion and metastasis of PC in vitro and in vivo."
37322017
reach
"USP33 promoted the proliferation, migration and invasion of PC cells."
37322017
reach
"Moreover, overexpression of USP33 Cys : His can slightly promote cell proliferation and invasion (XREF_SUPPLEMENTARY), instead of the inhibiting effects caused by USP33 wild type."
27835898
reach
"Moreover, we labeled EdU-positive PC cells to monitor the proliferation rate of PC cells, our data showed that EdU-positive cells was markedly reduced after USP33 downregulation while USP33 overexpression increased the proliferation rate of PC cells (Fig. 2F, G)."
37322017
reach
"Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma."
34470581
reach
"Thus, USP33 promotes PCa cell proliferation and self-renewal by inhibiting the degradation of CTNNB1."
37076992
reach
"In our research, we reported for the first time that USP33 mediated the proliferation and metastasis of pancreatic cancer through its deubiquitinating function which may provide a novel explanation for PC malignant development.USP33 was a member of the ubiquitin-specific protease (USP) family which was the largest deubiquitination enzymes (DUBs) family."
37322017
reach
"Using HeLa or HCT116 cells as a model, we analyzed the cell proliferation mediated by USP33."
28506875
reach
"On the other hand, USP33 knock-down promoted cell proliferation and invasion under SDF-1 stimulation; whereas dynasore (an internalization inhibitor) pretreatment in USP33 silencing cells showed a distinct antipromoting effect, revealing the participation of CXCR4 internalization in regulating tumor progress."
27835898
reach
"Deficiency of HIF1A or USP33 suppressed cell migration, proliferation and microtubule formation of hypoxia-exposed HRECs."
39320536
reach
"This is the first evidence for a lung cancer invasion and metastasis mechanism in which miR-365a-3p directly targets and downregulates USP33, which further promotes the proliferation, migration, and invasion activities of lung cancer."
29743814