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USP33 binds ARRB2. 21 / 22
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"These conformation-specific interactions are supported by observations from two sets of assays conducted in vitro: (1) interaction of purified β-arrestin2 and USP33 is augmented by addition of a synth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23764054
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19363159
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"While examining the kinetics of agonist-dependent association of endogenously expressed USP33 with β-arrestin2, characteristic binding patterns were revealed ()."
24377933
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19363159
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"Upon β 2 AR activation, the recruited β-arrestins are rapidly ubiquitinated and deubiquitinated, and this is facilitated by a high-affinity interaction between β-arrestin2 and USP33."
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"Upon beta 2 AR activation, the recruited beta-arrestins are rapidly ubiquitinated and deubiquitinated, and this is facilitated by a high-affinity interaction between beta-arrestin2 and USP33."
21680031
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"Upon stimulation of the βAR with isoproterenol, a robust increase in the association of β-arrestin2 and USP33 was detected."
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"Thus, isoproterenol stimulation induces a reciprocal pattern of USP33 interaction with the β 2 AR and β-arrestin2: dissociation of USP33 from the β 2 AR and association of USP33 with β-arrestin2."
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"Accordingly, the kinetics of beta-arrestin ubiquitination and deubiquitination are tightly regulated by USP33 ensuring the appropriate duration and magnitude of beta-arrestin-biased signaling.At a mol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This chapter focuses on the interaction of β-arrestin2 and USP33 and describes the assays used to determine the specific effects of USP33 on the trafficking of β-arrestin2 and on ERK signaling."
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"The immunoprecipitation assay showed that USP33 can interact with beta-arrestin2 in an agonist dependent manner."
27835898
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19424180
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"The immunoprecipitation assay showed that USP33 can interact with β-arrestin2 in an agonist-dependent manner (Figure xref )."
27835898
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"This chapter focuses on the interaction of beta-arrestin2 and USP33 and describes the assays used to determine the specific effects of USP33 on the trafficking of beta-arrestin2 and on ERK signaling."
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"At a molecular level, these effects are dependent upon conformation-specific interaction of USP33 and β-arrestin2."
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27835898