IndraLab

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USP33 deubiquitinates CCP110. 4 / 4
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"For example, USP33 deubiquitylates the centrosomal protein CP110, regulating centrosome biogenesis [76] and USP33 depletion has a co-operative effect with CDK2 on the CP110-dependent clustering function mentioned earlier [77]."
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"USP33 potently and specifically deubiquitinates CP110, but not other cyclin-F substrates."
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"USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110"
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"Thus, USP33 specifically de-ubiquitylates CP110 in vitro and in vivo, explaining how USP33 stabilizes CP110."
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