IndraLab

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USP33 deubiquitinates CCP110. 4 / 5
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"For example, USP33 deubiquitylates the centrosomal protein CP110, regulating centrosome biogenesis [76] and USP33 depletion has a co-operative effect with CDK2 on the CP110-dependent clustering function mentioned earlier [77]."
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"USP33 deubiquitinates the CP110 protein, an important regulator of centrosome duplication ( Li et al., 2013 )."
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"Thus, USP33 specifically de-ubiquitylates CP110 in vitro and in vivo, explaining how USP33 stabilizes CP110."
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"During centriole replication, USP33 deubiquitinates CP110, leading to CP110 instability, thereby inhibiting centrosome amplification and preventing mitotic defects."
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