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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP33 binds CH. 2 / 2

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"We also tested a catalytically inactive USP33 in which the cysteine and histidine residues of the active site are mutated (USP33-CH) for its effect on GCGR ubiquitination."

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"When we overexpressed USP33-CH in GCGR stable HEK-293 cells, we observed a significant increase in basal ubiquitination of the GCGR, but the mutant construct did not have a similar pronounced effect in blocking deubiquitination of agonist-activated GCGRs ( xref )."

32967969

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...