IndraLab

Statements

USP33 activates Pancreatic Neoplasms. 12 / 12
| 12
reach
"The overexpression of USP33 accelerated the proliferation, invasion and metastasis of PC in vitro and in vivo."
37322017
reach
"Taking together, our results demonstrated that USP33 promoted the tumor growth and metastasis of PC in a TGFBR2-dependent manner."
37322017
reach
"Moreover, we labeled EdU-positive PC cells to monitor the proliferation rate of PC cells, our data showed that EdU-positive cells was markedly reduced after USP33 downregulation while USP33 overexpression increased the proliferation rate of PC cells (Fig. 2F, G)."
37322017
reach
"To assess whether USP33 affected the invasiveness and migration of PC cells, we performed the transwell migration and invasion assays and found that USP33 knockdown significantly inhibited the migration and invasiveness of PC cells while USP33 overexpression showed the opposite effect (Fig. 2H–J)."
37322017
reach
"Our further experiments revealed that USP33 mediated the progression of PC cells through TGFBR2 which was a key regulator of TGFβ signaling pathway."
37322017
reach
"To investigate the role of TGFBR2 in USP33-mediated PC cell malignance, we performed the corresponding rescue experiments."
37322017
reach
"Through our function experiments, we found that USP33 promoted the proliferation, migration and invasion of PC in vitro and in vivo."
37322017
reach
"USP33/TGFBR2 axis promoted the tumor growth and metastasis of PC in vivo."
37322017
reach
"USP33 promoted the proliferation, migration and invasion of PC cells."
37322017
reach
"The results showed that knockdown of USP33 inhibited the liver metastasis of PC and increased the OS of PC bearing nude mice, while the overexpression of TGFBR2 remedied this phenotype (Fig. 8D–F)."
37322017
reach
"Our CCK-8 assay showed that USP33 knockdown significantly impaired the viability of PC cells while the overexpression of TGFBR2 rescued its effect (Fig. 4A–D)."
37322017
reach
"Function experiments revealed that USP33 overexpression promoted the proliferation, migration and invasion of PC cells while the inhibition of USP33 expression in PC cells exhibited the opposite effect."
37322017