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USP33 deubiquitinates TGFBR2. 4 / 4
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"Liu et al. reported that USP33 expression was increased among PC samples, which was correlated with poor survival of patients with PC; they found that USP33 could promote PC cell growth, migration, and invasion by triggering the deubiquitination of TGFBR2 (Liu et al. 2023)."
39589547
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"The USP33-regulated deubiquitination of TGFBR2 avoided its lysosomal degradation, meanwhile USP33 promoted the colocalization of TGFBR2 with recycling endosome which led to its accumulation on the membrane and the activation of TGFβ signaling."
37322017
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"Mechanistically, USP33 triggered the deubiquitination of TGFBR2 and prevented its degradation by lysosome, therefore promoted TGFBR2 accumulation in cell membrane and eventually contributed to the sustained activation of TGF-beta signaling."
37322017
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"Our results demonstrated that the K63R-Ub mutant and USP33 co-transfection had no effect on TGFBR2 ubiquitination, while the co-transfection of USP33 with other Ub mutants impaired the ubiquitination of TGFBR2 (Fig. 6E)."
37322017