IndraLab

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USP33 deubiquitinates GCGR. 3 / 3
| 3

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"Our data suggest that USP33 constitutively deubiquitinates the GCGR, whereas both STAMBP and USP33 deubiquitinate agonist-activated GCGRs at early endosomes."

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"USP33 knockdown drastically increases GCGR ubiquitination in quiescent cells; one possibility is that USP33 deubiquitinates and protects newly synthesized receptors from 26S proteasomal degradation."

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"Our data suggest that USP33 constitutively deubiquitinates the GCGR, whereas both STAMBP and USP33 deubiquitinate agonist activated GCGRs at early endosomes."