IndraLab

Statements

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"Interestingly, overexpression of USP33 significantly increased the cell migration (Fig. 3C) but not the proliferation (Fig. 3B) ability upon laminin coating."
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"These findings are the first to describe that USP33 promoted laminin-dependent cell migration by stabilizing integrin α6, which provides an insight into the mechanistic roles of USP33-integrin α6 axis in ESCC metastasis."
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"Deficiency of HIF1A or USP33 suppressed cell migration, proliferation and microtubule formation of hypoxia-exposed HRECs."
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"Expression of the C163A-mutant USP33 abolished Slit suppression of H1299 cell migration, supporting that deubiquitinating activity of USP33 is important in mediating Slit activity in inhibiting lung cancer cell migration."
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"Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT."
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"Moreover, we demonstrated that USP33 could mediate ESCC cell migration and metastasis through integrin α6."
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"USP33 is an integrin alpha6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis."
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"Mechanistically, USP33 mediates cell migration through binding, deubiquinating, and stabilizing integrin alpha6."
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"USP33 knockdown could inhibit ESCC cell migration and metastasis majorly through integrin alpha6."
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"We found that integrin α6 and USP33 overexpression in USP33-knockdown cells can largely rescue cell migration abilities on laminin in both KYSE-150 and KYSE-450 cells compared to indicated knockdown cells (Fig. 5C), which highlights the importance of integrin α6 in USP33-mediated ESCC cell migration on laminin."
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"For instance, USP33 contributes to Slit-mediated breast cancer cell migration [49]."
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