IndraLab

Statements

USP33 deubiquitinates ROBO1. 7 / 7
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"USP33 mediates Slit2 signaling by deubiquitinating and stabilizing Robo1."
25242263
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"USP33 deubiquitinates ROBO1 in lung cancer cells to maintain its stability, thereby regulating SLIT2 activity and inhibiting cancer cell metastasis [XREF_BIBR]."
29743814
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"Cell based assays support a model in which USP33 reverses Robo1 ubiquitination : knockdown of USP33 increases levels of ubiquitinated Robo1, while USP33 overexpression reduces ubiquitinated Robo1 levels [XREF_BIBR]."
21704388
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"These results show that USP33 mediates Slit-Robo signaling by deubiquitinating and stabilizing Robo1 in CRC cells (XREF_SUPPLEMENTARY)."
25242263
ubibrowser
"Robo-interacting ubiquitin-specific protease 33 (USP33) is required for the inhibitory function of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
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"USP33 deubiquitinates and stabilizes Robo1."
25242263
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"Though direct deubiquitination of Robo1 by USP33 has not been reported, it is reasonable to speculate that USP33 deubiquitinates and thus rescues Robo1 from degradation during the Slit response."
21704388