IndraLab

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USP33 inhibits ROBO1. 2 / 3

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"Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells."

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"Similarly, the downregulation of USP33 (a ubiquitin ligase enzyme) reduces the stability of the ROBO1 receptor in lung cancer cells 29 and breast cancer cell migration 30."

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IndraLab

Statements

USP33 inhibits ROBO1. 2 / 3

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