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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP33 leads to the deubiquitination of beta-arrestins. 2 / 2

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"We now report the discovery that the deubiquitinating enzyme ubiquitin specific protease 33 (USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins."

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"Deubiquitination of beta-arrestins is also regulated by agonist activation of the beta2AR and other GPCRs and is mediated by USP20 and USP33 and is important for beta, arrestin, and beta2AR complex disassembly, lysosomal sorting and signaling [XREF_BIBR, XREF_BIBR] (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...