IndraLab

Statements

USP33 inhibits CXCR4. 3 / 5
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"We demonstrated that USP33 overexpression can attenuate CXCR4 internalization, while USP33 knock-down showed the opposite effect."
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"We also demonstrated that in the LoVo cells transfected with CXCR4, overexpression of beta-arrestin2 can further promote cell proliferation, while co-overexpression of USP33 can attenuate the oncogenetic effects of CXCR4 (XREF_SUPPLEMENTARY)."
27835898
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"On the other hand, we tested the level of total receptors after SDF-1 stimulation and demonstrated that USP33 knock-down can increase the degradation of CXCR4, while USP33 overexpression can inhibit its degradation."
27835898