IndraLab

Statements

PRPF8 affects SNRNP200
17 | 19 22
PRPF8 binds SNRNP200.
17 | 10 19
SNRNP200 binds PRPF8. 10 / 38
17 | 9 12
sparser
"Furthermore, TSSC4 directly interacts with the SNRNP200 (U5 snRNP 200 kDa helicase) and the PRPF8 spliceosomal scaffold."
39697342
biogrid
No evidence text available
40437099
sparser
"For example, pathogenic variants in PRPF8 and SNRNP200 were clustered in their interaction regions, where defects disrupted PRPF8–SNRNP200 interactions. xref – xref Previously, situations similar to that of TOPORS have been reported in the RP1 gene, in which causative heterozygous truncating variants are only located in a specific region in the middle of the gene. xref – xref Regarding TOPORS , products resulting from pathogenic truncating variants located in the last exon and downstream of the SR/RS domain may escape nonsense-mediated mRNA decay (NMD) xref and reduce the activity of the wild-type allele via the dominant-negative effect."
35579903
biogrid
No evidence text available
27173435
reach
"In the nucleus, PRPF8 is forming a complex with EFTUD2 and SNRNP200 (also known as BRR2) as part of the spliceosome."
34951455
biogrid
No evidence text available
22939629
sparser
"In addition, a small but reproducible reduction of SNRNP200 and PRPF8 binding was also observed in the case of the Δ201–250 deletion mutant."
34131137
biogrid
No evidence text available
31839598
biogrid
No evidence text available
26344197
reach
"These Prp8-RP mutants directly affect U5 snRNP and tri-snRNP maturation (Boon et al. 2007), Brr2 helicase, and ATPase activities (Pena et al. 2007; Maeder et al. 2009; Mozaffari-Jovin et al. 2013), and yeast-two-hybrid interactions between Brr2, Prp8, and Snu114 (Table 1; Pena et al. 2007)."
26968627
PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
sparser
"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
34131137
sparser
"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
sparser
"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
sparser
"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
26392272
reach
"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
25450007
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
PRPF8 inhibits SNRNP200.
| 4 3
PRPF8 inhibits SNRNP200. 7 / 7
| 4 3
reach
"A C-terminal fragment of Prp8 was shown to inhibit Brr2 ATPase activity in vitro [ 35 ]."
22464735
sparser
"Given the mechanistic analogy between histone mRNA processing and splicing, we thus envisage that SLBP ubiquitylation may suppress hPrp43 helicase activity in histone mRNA processing similar to Prp8 u[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27203182
reach
"These proteins show multiple strong genetic (Kuhn et al. 2002; Bottner et al. 2005; Grainger and Beggs 2005; Liu et al. 2006), yeast-two-hybrid (van Nues and Beggs 2001), and physical interactions (Achsel et al. 1998), indicating a high degree of coordination between them.Initial genetic evidence indicated that the Prp8 C-terminal Jab1/MPN domain negatively regulated Brr2 unwinding during splicing (Kuhn and Brow 2000; Kuhn et al. 2002)."
26968627
reach
"Thus Prp8-RP mutations provide a potent tool to understand how deregulation of Brr2 by Prp8 impacts splicing.Here we present evidence that Prp8-RP mutants deregulate Brr2 activity both in vitro and in vivo."
26968627
sparser
"A model was proposed in which inhibition of Brr2 by the ubiquitinated Prp8 leads to spliceosome assembly and stabilization of the triple snRNP (U4/U6–U5)."
| PMC
sparser
"In humans, phosphorylation of Prp6 that occurs after the tri-snRNP being integrated into the B-complex may release the inhibition of Brr2 by Prp8 and is important for spliceosomal B-complex activation [ xref , xref ]."
27058959
reach
"The RNase H domain of PRPF8 inhibits loading of SNRNP200 to U4 snRNA, and a C-terminal part of PRPF8 modulates the SNRNP200 activity for the unwinding of U4/U6 snRNA duplex XREF_BIBR - XREF_BIBR."
25450007
PRPF8 activates SNRNP200.
| 5
PRPF8 activates SNRNP200. 5 / 5
| 5
reach
"The carboxy‐terminal region of the spliceosomal protein PRPF8, which modulates the RNA helicase Brr2, is a mutation hotspot linked to retinitis pigmentosa‐type 13, although its precise function in human splicing and tissue‐specific mechanisms remains unclear."
40066647
reach
"Although it has been demonstrated that the PRPF8 RNase H domain inhibits SNRNP200 activity and GTP bound EFTUD2 and that the C-terminus of PRPF8 induces the activation of SNRNP200 XREF_BIBR - XREF_BIBR, the detailed molecular mechanisms of the activation of SNRNP200 remains to be determined."
25450007
reach
"Prp8, which directly regulates Brr2 activity (Maeder et al. 2009; Nielsen and Staley 2012; Mozaffari-Jovin et al. 2013; Nguyen et al. 2013), has also been implicated in 3′SS selection (Umen and Guthrie 1995a,b, 1996; Siatecka et al. 1999) as well as the transition between the first and second catalytic steps (Frank et al. 1992; Query and Konarska 2004; Liu et al. 2007)."
26968627
reach
"Indeed a C-terminal fragment of Prp8 — encompassing the RNaseH-like and Jab/MPN1-like domains — strongly stimulates Brr2-dependent U4/U6 unwinding in vitro [ 44 ]."
20089394
reach
"The RNase H domain of PRPF8 inhibits loading of SNRNP200 to U4 snRNA, and a C-terminal part of PRPF8 modulates the SNRNP200 activity for the unwinding of U4/U6 snRNA duplex XREF_BIBR - XREF_BIBR."
25450007
PRPF8 is modified
5 | 51
PRPF8 is phosphorylated.
5 | 40
PRPF8 is phosphorylated. 10 / 38
| 38
sparser
"In addition, okadaic acid-induced hyperphosphorylation of elF-4E and p220 results in the recruitment of more p220 protein into the cap- binding complex 1731."
7599274
sparser
"Thus, eIF-4F p220, eIF-4B and ribosomal protein S6 are phosphorylated via PMA-dependent and insulin-dependent pathways, whereas phosphorylation of eIF-4F p25 and eIF-3 p120 is stimulated only upon activation of protein kinase C. Phosphopeptide maps of eIF-4F p220 and ribosomal protein S6 suggest that protease-activated kinase II is one of the protein kinases involved in the insulin-stimulated response in protein kinase C-depleted cells."
2191953
sparser
"This kinase was not inhibited by the cAMP-dependent protein kinase inhibitory peptide IAAGRTGRRNAIHDILVAA, did not phosphorylate $6 ribosomal protein, did not phosphorylate p220 of elF-4F as protein kinase C does and no other substrates for this kinase were apparent in reticulocyte ribosomal salt wash."
2967701
sparser
"Selective inhibition of p220 NPAT phosphorylation by CKIs at Subnuclear Foci."
19170105
sparser
"To facilitate histone genes transcription during cell cycle cyclin E/CDK2 phosphorylates p220(NPAT) [ xref ]."
26059433
sparser
"Partial digests of phosphorylated p180 and p220 produced with chymotrypsin or V8 protease reveal that each protein has a distinct phosphopeptide pattern."
4063966
sparser
"Moreover, anti-TNF-alpha antibodies inhibit LPS-stimulated phosphorylation of eIF-4E and p220 by 43% (+/- 6%) and 50% (+/- 5%), respectively."
1345341
sparser
"We report here that insulin-like growth factor I-stimulated phosphorylation of two endogenous substrate proteins, pp220 and pp170, is also inhibited in cells expressing A/K1018 receptors."
2153140
sparser
"Addition of insulin to these down-regulated cells leads to stimulation of phosphorylation of eIF-4F p220, ribosomal protein S6, and to a lesser extent, eIF-4B; little or no stimulation of phosphorylation of eIF-4F p25 and eIF-3 p120 is observed."
2191953
sparser
"We have further found that p220 is phosphorylated specifically in M phase."
1327753
PRPF8 is phosphorylated on Y254. 2 / 2
2 |
hprd
No evidence text available
20068231
hprd
No evidence text available
18452278
PRPF8 is phosphorylated on serine. 2 / 2
| 2
sparser
"Phosphoamino acid analysis of the isolated proteins demonstrated that both P220 and P180 were phosphorylated only at serine residues (Fig. 3, A and B)."
4062988
sparser
"Both p180 and p220 are phosphorylated exclusively at serine residues."
4063966
PRPF8 is phosphorylated on T247. 1 / 1
1 |
hprd
No evidence text available
20068231
PRPF8 is phosphorylated on S2079. 1 / 1
1 |
hprd
No evidence text available
18669648
PRPF8 is phosphorylated on S1027. 1 / 1
1 |
hprd
No evidence text available
20068231
PRPF8 is ubiquitinated.
| 9
PRPF8 is ubiquitinated. 9 / 9
| 9
sparser
"A model was proposed in which inhibition of Brr2 by the ubiquitinated Prp8 leads to spliceosome assembly and stabilization of the triple snRNP (U4/U6–U5)."
| PMC
sparser
"In addition to recent studies suggesting that ubiquitination of Prp8 regulates tri-snRNP disassembly, xref , xref there are other indications that ubiquitin or ubiquitin-like proteins (such as Sumo and Hub1) play additional roles in splicing."
20672149
sparser
"Shortly afterwards, it was also demonstrated that the E3 ligase named Prp19 increases the affinity between the ubiquitinated Prp3 protein and Prp8, thus contributing to stabilization of the triple snRNP."
| PMC
sparser
"Staley and Sontheimer uncovered a regulatory mechanism, namely that the activity of Brr2 is negatively regulated by ubiquitination of Prp8 (ref. xref )."
19098916
sparser
"Finally, we show that the conserved splicing factor Prp8 is ubiquitinated within purified triple snRNPs."
18425143
sparser
"Later, it was shown that ubiquitination and deubiquitination of Prp8 might regulate U4/U6 unwinding required for activation of the spliceosome [ xref ]."
36983760
sparser
"Prp8, a key RNA-binding splicing factor, is ubiquitylated to suppress the U4/U6 snRNAs unwinding activity of Brr2 helicase and promote spliceosome assembly."
27203182
sparser
"Important questions that can be addressed using our minimal system include determining whether the Prp8-CTF also promotes Brr2-depending unwinding of U2 and U6, and whether helicase activity is inhibited by Prp8 ubiquitination."
19098916
sparser
"It was further demonstrated that Prp8 is ubiquitinated within the tri-snRNP ( xref )."
20462492
PRPF8 is methylated.
| 2
PRPF8 is methylated. 2 / 2
| 2
sparser
"There is no appreciable difference in Dnmt3a methylation activity on plasmids with and without Dcm methylation when the methylation sensitive enzyme HhaI is used to assess DNA methylation on p220.2 (Fig. xref , lanes 1 and 2)."
15799776
sparser
"Unmethylated p220.2 showed 50.8% methylation in the EBNA1 region 2, 36.3% methylation in the EBNA1 region 4, and 6.3% methylation in the EBNA1 region 6 (Fig. xref )."
15799776
EFTUD2 affects PRPF8
22 | 8 18
EFTUD2 binds PRPF8.
22 | 7 18
PRPF8 binds EFTUD2. 10 / 36
22 | 6 8
biogrid
No evidence text available
35271311
biogrid
No evidence text available
39358380
sparser
"The HSP90/R2TP machinery binds unassembled cytoplasmic forms of PRPF8 and EFTUD2."
28515276
sparser
"To determine whether the interactions between R2TP and PRPF8 or EFTUD2 occur at an early cytoplasmic stage, we implemented a corecruitment assay using a fusion of RPAP3 with a fragment of p54, which targets the fusion protein to cytoplasmic P-bodies ( xref )."
28515276
sparser
"This indicated that EFTUD2 interacts with R2TP in the cytoplasm independently of PRPF8."
28515276
sparser
"SNRNP200 is a large nuclear protein of 200 kDa, which interacts extensively with U5-specific proteins EFTUD2 (hSnu114) and Prpf8."
27302685
sparser
"Collectively, our data confirm that interactions of the R2TP complex with PRPF8 and EFTUD2 occur early on in the cytoplasm and are independent of each other."
28515276
sparser
"We also identified several U5 chaperones such as AAR2, ZNHIT2, RUVBL1, RUVBL2, and ECD and a putative chaperone EAPP that has been shown to interact with U5 proteins PRPF8 and EFTUD2 xref , xref , xref ."
34131137
reach
"In the nucleus, PRPF8 is forming a complex with EFTUD2 and SNRNP200 (also known as BRR2) as part of the spliceosome."
34951455
reach
"To determine whether the interactions between R2TP and PRPF8 or EFTUD2 occur at an early cytoplasmic stage, we implemented a corecruitment assay using a fusion of RPAP3 with a fragment of p54, which targets the fusion protein to cytoplasmic P-bodies."
28515276
PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
sparser
"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
34131137
sparser
"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
sparser
"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
sparser
"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
26392272
reach
"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
25450007
PRPF8 binds AAR2 and EFTUD2. 2 / 2
| 2
sparser
"Collectively, these data provide strong support for the idea that PRPF8 associates with EFTUD2 and AAR2 early in its assembly pathway."
28515276
sparser
"These results support the idea that PRPF8, AAR2, and EFTUD2 form an assembly intermediate in human cells and that some of the mutants are trapped at this stage."
28515276
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
R2TP binds PRPF8 and EFTUD2. 1 / 1
| 1
sparser
"Depletion of U5 proteins and PRPF8 RP mutation both increase the association of PRPF8 and EFTUD2 with R2TP."
28515276
EFTUD2 decreases the amount of PRPF8.
| 1
EFTUD2 decreases the amount of PRPF8. 1 / 1
| 1
reach
"EFTUD2′s roles during MRV infection are summarized in Figure 7B.We previously demonstrated that MRV reduces the protein levels of EFTUD2, PRPF8, and SNRNP200 through the action of the μ2 protein during infection [5]."
36560714
SNRNP200 affects PRPF8
17 | 10 19
SNRNP200 binds PRPF8. 10 / 38
17 | 9 12
sparser
"Furthermore, TSSC4 directly interacts with the SNRNP200 (U5 snRNP 200 kDa helicase) and the PRPF8 spliceosomal scaffold."
39697342
biogrid
No evidence text available
40437099
sparser
"For example, pathogenic variants in PRPF8 and SNRNP200 were clustered in their interaction regions, where defects disrupted PRPF8–SNRNP200 interactions. xref – xref Previously, situations similar to that of TOPORS have been reported in the RP1 gene, in which causative heterozygous truncating variants are only located in a specific region in the middle of the gene. xref – xref Regarding TOPORS , products resulting from pathogenic truncating variants located in the last exon and downstream of the SR/RS domain may escape nonsense-mediated mRNA decay (NMD) xref and reduce the activity of the wild-type allele via the dominant-negative effect."
35579903
biogrid
No evidence text available
27173435
reach
"In the nucleus, PRPF8 is forming a complex with EFTUD2 and SNRNP200 (also known as BRR2) as part of the spliceosome."
34951455
biogrid
No evidence text available
22939629
sparser
"In addition, a small but reproducible reduction of SNRNP200 and PRPF8 binding was also observed in the case of the Δ201–250 deletion mutant."
34131137
biogrid
No evidence text available
31839598
biogrid
No evidence text available
26344197
reach
"These Prp8-RP mutants directly affect U5 snRNP and tri-snRNP maturation (Boon et al. 2007), Brr2 helicase, and ATPase activities (Pena et al. 2007; Maeder et al. 2009; Mozaffari-Jovin et al. 2013), and yeast-two-hybrid interactions between Brr2, Prp8, and Snu114 (Table 1; Pena et al. 2007)."
26968627
PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
sparser
"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
34131137
sparser
"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
sparser
"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
sparser
"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
26392272
reach
"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
25450007
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
PRPF8 affects AAR2
11 | 11 19
AAR2 binds PRPF8. 10 / 39
11 | 11 17
reach
"PRPF8 binding to R2TP and AAR2 chaperones was increased in the absence of PIH1D1, suggesting that the formation of the R2TP complex through PIH1D1 binding is important for the release of PRPF8 from R2TP and AAR2 [59]."
36008939
biogrid
No evidence text available
28561026
biogrid
No evidence text available
34079125
biogrid
No evidence text available
26186194
sparser
"Despite the biochemical and structural evidence reported previously, which supports this switch, a caveat of our AAR2–PRPF8 RH structure may be that the RH β-finger module makes crystal contacts with a neighboring symmetry-related RH β-finger module."
36322420
sparser
"In contrast, our observations of (i) human AAR2 failing to sequester the PRPF8 JM domain from SNRNP200 395–2136 and (ii) AAR2 concomitantly binding to a PRPF8 fragment encompassing the RH and JM domains and SNRNP200 395–2136 suggest that an equivalent, long-lived intermediate is not formed in the human system."
36322420
reach
"CK2α1 and SGK2 kinases can abrogate the interaction between the spliceosomal proteins AAR2 and PRPF8, and NEK6 kinase was found to mediate the estrogen receptor (ERα) interaction with 14-3-3 proteins."
35225431
sparser
"In the cytoplasm, PRPF8 forms a complex with AAR2, a protein required for the assembling of U5 snRNP that is replaced by the SNRNP200 helicase after PRPF8 is transported from the cytoplasm to the nucleus ( xref , xref )."
34951455
reach
"Nevertheless, the GFP-AAR2 IP purified only a few other U5 proteins, which is in agreement with the idea that AAR2 binds PRPF8 mostly before its association with U5 snRNA."
28515276
biogrid
No evidence text available
22939629
PRPF8 binds AAR2 and EFTUD2. 2 / 2
| 2
sparser
"Collectively, these data provide strong support for the idea that PRPF8 associates with EFTUD2 and AAR2 early in its assembly pathway."
28515276
sparser
"These results support the idea that PRPF8, AAR2, and EFTUD2 form an assembly intermediate in human cells and that some of the mutants are trapped at this stage."
28515276
SNRNP40 affects PRPF8
18 |
SNRNP40 binds PRPF8. 10 / 18
18 |
biogrid
No evidence text available
37689310
biogrid
No evidence text available
16723661
biogrid
No evidence text available
35271311
biogrid
No evidence text available
31839598
biogrid
No evidence text available
9774689
biogrid
No evidence text available
34079125
biogrid
No evidence text available
22939629
biogrid
No evidence text available
9774689
biogrid
No evidence text available
35235311
biogrid
No evidence text available
40437099
PRPF8 affects CD2BP2
14 | 2
CD2BP2 binds PRPF8. 10 / 16
14 | 2
biogrid
No evidence text available
33961781
biogrid
No evidence text available
17353931
biogrid
No evidence text available
31839598
reach
"The CD2BP2 ‘Hook’ (residues 64-123) bridges the PRP8 N-terminal (PRP8 ) and Large (PRP8 ) domains and binds a bent conformation of the regulatory PRP8 α-finger (Fig. 2b, c, Extended Data Fig. 4d)."
38467876
biogrid
No evidence text available
28561026
biogrid
No evidence text available
26344197
biogrid
No evidence text available
35271311
biogrid
No evidence text available
35831314
biogrid
No evidence text available
22939629
reach
"The CD2BP2 ‘Bundle’ would bind PRP8 and deliver the CD2BP2 GYF–DIM1 complex to the nearby PRP6 N-terminus, tethering DIM1 near its PRP8-binding site, which is occluded by the CD2BP2 ‘Hook’ (States II-IV) (Extended Data Fig. 4e)."
38467876
PRPF8 affects PRPF6
13 | 1 1
PRPF6 binds PRPF8. 10 / 15
13 | 1 1
biogrid
No evidence text available
40437099
biogrid
No evidence text available
34079125
biogrid
No evidence text available
10788320
sparser
"Because PRPF6 and hDib1 interact directly [19] , we determined whether luciferase activity was regenerated similarly by NO-PRPF6 and OC-U5-40K. When these reporter proteins were synthesized in vitro a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24503441
biogrid
No evidence text available
27173435
biogrid
No evidence text available
35235311
reach
"However, neither of the two Prpf8 aberrant mutations studied in this work affect the Prpf8 interaction with Prpf6 and Snrnp200 and snRNP maturations (Malinova et al, 2017, and Fig S1C)."
37019475
biogrid
No evidence text available
16723661
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28515276
PRPF8 affects DDX23
14 | 1
DDX23 binds PRPF8. 10 / 15
14 | 1
biogrid
No evidence text available
35235311
biogrid
No evidence text available
35271311
biogrid
No evidence text available
26186194
biogrid
No evidence text available
26344197
biogrid
No evidence text available
31839598
biogrid
No evidence text available
34079125
biogrid
No evidence text available
33961781
sparser
"The N-terminal domain of PRPF8 interacts with the helicase DDX23 (linked to U1 snRNP), whereas its C-terminal domain Jab1 links the tri-snRNP nucleus to the SNRNP200 protein ( xref ; xref )."
36609432
biogrid
No evidence text available
26414014
biogrid
No evidence text available
40437099
PRPF6 affects PRPF8
13 | 1 1
PRPF6 binds PRPF8. 10 / 15
13 | 1 1
biogrid
No evidence text available
40437099
biogrid
No evidence text available
34079125
biogrid
No evidence text available
10788320
sparser
"Because PRPF6 and hDib1 interact directly [19] , we determined whether luciferase activity was regenerated similarly by NO-PRPF6 and OC-U5-40K. When these reporter proteins were synthesized in vitro a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24503441
biogrid
No evidence text available
27173435
biogrid
No evidence text available
35235311
reach
"However, neither of the two Prpf8 aberrant mutations studied in this work affect the Prpf8 interaction with Prpf6 and Snrnp200 and snRNP maturations (Malinova et al, 2017, and Fig S1C)."
37019475
biogrid
No evidence text available
16723661
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28515276
DDX23 affects PRPF8
14 | 1
DDX23 binds PRPF8. 10 / 15
14 | 1
biogrid
No evidence text available
35235311
biogrid
No evidence text available
35271311
biogrid
No evidence text available
26186194
biogrid
No evidence text available
26344197
biogrid
No evidence text available
31839598
biogrid
No evidence text available
34079125
biogrid
No evidence text available
33961781
sparser
"The N-terminal domain of PRPF8 interacts with the helicase DDX23 (linked to U1 snRNP), whereas its C-terminal domain Jab1 links the tri-snRNP nucleus to the SNRNP200 protein ( xref ; xref )."
36609432
biogrid
No evidence text available
26414014
biogrid
No evidence text available
40437099
SART3 affects PRPF8
4 | 4 6
PRPF8 binds SART3. 10 / 14
4 | 4 6
sparser
"At least two pieces of evidence provide support for the nuclear miR-10b maturation scenario: first, the finding of Ago2 and, more recently, of Dicer in the nucleus of specific cells, including glioma (Suppementary Fig. xref a) and [ xref , xref – xref ], and second, the co-IP of the spliceosomal SART3 and PRPF8 complexes with Ago2, the core endonucleolytic components of RISC that efficiently pools-down the entire miR-10b population from glioma cells."
35033060
reach
"At least two pieces of evidence provide support for the nuclear miR-10b maturation scenario: first, the finding of Ago2 and, more recently, of Dicer in the nucleus of specific cells, including glioma (Suppementary Fig. 5a) and [12, 56–58], and second, the co-IP of the spliceosomal SART3 and PRPF8 complexes with Ago2, the core endonucleolytic components of RISC that efficiently pools-down the entire miR-10b population from glioma cells."
35033060
reach
"Both U6 and miR-10b have been significantly enriched in the spliceosomal SART3 and PRPF8 complexes (Fig. 3a and Supplementary Fig. 4a, b)."
35033060
sparser
"These results indicate that miR-10b interferes with U6 incorporation into SART3 and PRPF8 snRNPs."
35033060
reach
"Furthermore, miR-10b- U6 chimeras have been detected in the cross-linked and ligated SART3 and PRPF8 complexes, similar to the Ago complexes (Fig. 3b) indicative of the miR-10b interaction with U6 snRNP in the splicing complex."
35033060
biogrid
No evidence text available
28515276
biogrid
No evidence text available
37448957
biogrid
No evidence text available
22939629
sparser
"We further demonstrate that miR-10b modulates U6 N-6-adenosine methylation and pseudouridylation, U6 binding to splicing factors SART3 and PRPF8, and regulates U6 stability, conformation, and levels."
35033060
sparser
"Both U6 and miR-10b have been significantly enriched in the spliceosomal SART3 and PRPF8 complexes (Fig. xref a and Supplementary Fig. xref a, b)."
35033060
PRPF8 affects ECD
9 | 1 4
PRPF8 binds ECD. 10 / 14
9 | 1 4
reach
"ZNHIT2, ECD, AAR2 and PRPF8 can form complexes with R2TP."
34951455
biogrid
No evidence text available
28514442
sparser
"Such a role was consistent with our and others' findings that ECD associates with the core spliceosome scaffold protein PRPF8 ( xref )."
34670863
biogrid
No evidence text available
35271311
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22939629
biogrid
No evidence text available
33961781
sparser
"Notably, mammalian PRPF8 also interacts with ECD ( xref ), and another study found ECD, PRPF8, and R2TP subunits in a single complex ( xref )."
33941617
sparser
"Drosophila and human ECD proteins bind to PRPF8, an essential scaffolding component of the spliceosome machinery ( xref ), suggesting a role of ECD in splicing."
34670863
sparser
"The interaction of human ECD with human PRPF8 has been confirmed [ xref ]."
28492064
biogrid
No evidence text available
28515276
SART1 affects PRPF8
11 | 2
SART1 binds PRPF8. 10 / 13
11 | 2
biogrid
No evidence text available
30021884
biogrid
No evidence text available
11350945
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39358380
biogrid
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35235311
biogrid
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39358380
biogrid
No evidence text available
28515276
reach
"To interrogate the functionality of the modeled interaction between SNU66, SNRP27, and PRP8, we used a CRISPR–cas9 system coupled with an oligonucleotide-directed recombination repair-based screen to randomize snu-66 at position H765 and prp-8 at position H1573, and screened for viable mutants.We initially recovered nine independent strains, with five different amino acid substitutions at snu-66 position H765; G, L, S, C, and T."
38443114
biogrid
No evidence text available
35575683
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35271311
reach
"Meanwhile, circRNA-UBAP2 represses apoptosis and contributes to the proliferation of ovarian cancer by miR-382-5p/PRPF8 axis (Xu et al., 2020)."
34122108
reach
"In ovarian cancer, PRPF8 expression significantly promotes ovarian cancer cell proliferation and inhibits apoptosis through the circRNA-UBAP2/miR-382-5p/PRPF8 pathway [69]."
40136404
reach
"In Drosophila, loss of PRPF8 decreases cell proliferation, increases cell death and modulates cell differentiation and polarity, and PRPF8-mediated hyperplastic growth is induced by different oncogenes ."
36609600
reach
"Silencing PRPF8 significantly reduced cell proliferation at 24–72 h in all cell lines tested (Fig. 3c)."
36609600
reach
"Alterations of PRPF8 increase the proliferation of CD34+ primary bone marrow cells and of a myeloid cell line, as well as resulting in defects of the second step of the RNA splicing process [58]."
35885562
eidos
"( C ) The expression location of Prp8 was explored via immunofluorescence ( D ) CCK8 assay revealed that loss of Prp8 reduced cell proliferation ."
32547101
reach
"Indeed, in vitro PRPF8 silencing reduced the proliferation of different liver cancer cell lines through the modulation of important CDKs such as CDK2, reduced the migration capacity, and reduced the colony and tumorsphere formation capacity, all of which are important features related to the control of cancer stem cell viability and cancer progression."
36609600
reach
"We show that PRPF8 lesions lead to neomorphic spliceosomal activity and increased cellular proliferation resulting in a distinct phenotype of aggressive myeloid malignancies with increased RS."
24781015
reach
"CircRNA-UBAP2 can be used as a ceRNA of spongy miR-382-5p in ovarian cancer, increasing the expression level of PRPF8, promoting the proliferation of ovarian cancer cells, and inhibiting cell apoptosis (Xu et al., 2020)."
34504842
reach
"Consequently, circRNA-UBAP2 upregulated expression level of PRPF8 by sponged miR-382-5p acted as a ceRNA, promoted proliferation and inhibited apoptosis in ovarian cancer cells."
32690086
PRPF8 inhibits cell population proliferation. 1 / 1
| 1
reach
"Unlike SF3B1, XREF_BIBR, XREF_BIBR PRPF8 knockdown leads to increased cellular proliferation and increased clonogenicity."
24781015
PRPF8 affects SART1
11 | 2
SART1 binds PRPF8. 10 / 13
11 | 2
biogrid
No evidence text available
30021884
biogrid
No evidence text available
11350945
biogrid
No evidence text available
39358380
biogrid
No evidence text available
35235311
biogrid
No evidence text available
39358380
biogrid
No evidence text available
28515276
reach
"To interrogate the functionality of the modeled interaction between SNU66, SNRP27, and PRP8, we used a CRISPR–cas9 system coupled with an oligonucleotide-directed recombination repair-based screen to randomize snu-66 at position H765 and prp-8 at position H1573, and screened for viable mutants.We initially recovered nine independent strains, with five different amino acid substitutions at snu-66 position H765; G, L, S, C, and T."
38443114
biogrid
No evidence text available
35575683
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35271311
PRPF31 affects PRPF8
5 | 7
PRPF31 binds PRPF8.
5 | 6
PRPF31 binds PRPF8. 10 / 11
5 | 6
reach
"The interaction of PRP31 or PRP3 and the U5 snRNP component PRP8 is reported to be regulated by the ubiquitination and deubiquitination status of PRP31 and PRP3, which is required for efficient RNA sp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31330151
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28088760
reach
"In the spliceosome, ubiquitinated PRP3 and PRP31 bind PRP8 and stabilize the tri-snRNP complex [31] ."
30269981
reach
"These results indicated that PRP3 inhibits radioresistance at least in part due to promoting the production of FANCI‐12.2.6 PRP3 regulates FANCI alternative splicing by modulating the interaction between PRP31 and PRP8."
37168687
reach
"These observations indicated that PRP3 regulates FANCI alternative splicing by modulating the interaction between PRP31 and PRP8, the key components of complex B. Considering that PRP31 and PRP8 were downregulated in cells postradiation, these findings also demonstrate that PRP3 plays a functional role in the early step of cellular response to radiation.2.7 TXNL4B promotes radioresistance of lung cancer in vivo."
37168687
biogrid
No evidence text available
28515276
reach
"In addition, we found that PRP3 knockdown weakened the interaction of PRP31 and PRP8, which are key components for the assembly of U4/U6.U5 tri‐snRNP; this, in turn, led to FANCI exon skipping."
37168687
reach
"Mechanistically, PRP3 knockdown leads to the unstabilized U4/U6.U5 tri‐snRNP postradiation though affecting the physical interaction of PRP31 and PRP8."
37168687
PRPF31 activates PRPF8.
| 1
PRPF31 activates PRPF8. 1 / 1
| 1
reach
"Ubiquitination of Prp31 increases its affinity for Prp8 and this PTM is reversed by USP15."
| PMC
SF3B4 affects PRPF8
5 | 4 2
SF3B4 binds PRPF8. 10 / 11
5 | 4 2
reach
"In addition, physical interactions between RBM39 and SF3A1/2/3, SF3B4, PRPF8 and MBNL1 have also been reported (Figure 5A) (10,83)."
36477312
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
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28515276
reach
"A heatmap of the enrichment of snRNA-binding proteins showed validated patterns, with the specific binding of PRPF8 and SF3B4 to U4/5/6 and U2 snRNAs, respectively (Figure 5E)."
38955188
biogrid
No evidence text available
22365833
reach
"Utilizing the publicly available GnomAD32 database, we replicate findings where regions with known RBP function are more likely to contain rare (minor allele frequency [MAF] < 0.1%) and disruptive (Δln(LR) < −0.5) variants (Figure 7C, Mann-Whitney test p < 0.001).33 For example, rare variants disrupting SF3B4 and PRPF8 binding are enriched in proximal introns near 5′ SS and 3′ SS, respectively, resonating with the known splice-site-defining function of both spliceosomal proteins."
38955188
reach
"To explore potential combinatorial binding between SF3B4 and PRPF8, the likelihood of dual binding was juxtaposed with other clusters, encompassing those with solitary binding from either RBP."
38955188
biogrid
No evidence text available
35831314
sparser
"A heatmap of the enrichment of snRNA-binding proteins showed validated patterns, with the specific binding of PRPF8 and SF3B4 to U4/5/6 and U2 snRNAs, respectively ( xref E)."
38955188
PRPF8 affects PRPF31
5 | 6
PRPF31 binds PRPF8. 10 / 11
5 | 6
reach
"The interaction of PRP31 or PRP3 and the U5 snRNP component PRP8 is reported to be regulated by the ubiquitination and deubiquitination status of PRP31 and PRP3, which is required for efficient RNA sp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31330151
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28088760
reach
"In the spliceosome, ubiquitinated PRP3 and PRP31 bind PRP8 and stabilize the tri-snRNP complex [31] ."
30269981
reach
"These results indicated that PRP3 inhibits radioresistance at least in part due to promoting the production of FANCI‐12.2.6 PRP3 regulates FANCI alternative splicing by modulating the interaction between PRP31 and PRP8."
37168687
reach
"These observations indicated that PRP3 regulates FANCI alternative splicing by modulating the interaction between PRP31 and PRP8, the key components of complex B. Considering that PRP31 and PRP8 were downregulated in cells postradiation, these findings also demonstrate that PRP3 plays a functional role in the early step of cellular response to radiation.2.7 TXNL4B promotes radioresistance of lung cancer in vivo."
37168687
biogrid
No evidence text available
28515276
reach
"In addition, we found that PRP3 knockdown weakened the interaction of PRP31 and PRP8, which are key components for the assembly of U4/U6.U5 tri‐snRNP; this, in turn, led to FANCI exon skipping."
37168687
reach
"Mechanistically, PRP3 knockdown leads to the unstabilized U4/U6.U5 tri‐snRNP postradiation though affecting the physical interaction of PRP31 and PRP8."
37168687
PRPF8 affects PRPF3
6 | 2 3
PRPF8 binds PRPF3. 10 / 10
6 | 2 2
biogrid
No evidence text available
28515276
reach
"The interaction of PRP31 or PRP3 and the U5 snRNP component PRP8 is reported to be regulated by the ubiquitination and deubiquitination status of PRP31 and PRP3, which is required for efficient RNA sp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31330151
biogrid
No evidence text available
35271311
biogrid
No evidence text available
34144037
reach
"The SNRNP200, PRPF8, PRPF3, and PRPF31 gene products are all triple-snRNP components, 15,31 and PAP1 binds PRPF3 to negatively regulate splicing, 32,49 suggesting a common mechanism for pathogenesis."
19878916
sparser
"It is interesting to note that the interaction of PRPF8 with ubiquitinated PRPF3 is regulated by the deubiquitinating enzyme USP4, and that loss of USP4 prevents the correct splicing of mRNAs including those for α-tubulin xref ."
26167768
biogrid
No evidence text available
22939629
biogrid
No evidence text available
20595234
sparser
"As the second and third PE targets, we chose PRPF3 and PRPF8 associated with autosomal dominant (ad) forms of retinitis pigmentosa (RP) [ xref , xref ]."
39795970
biogrid
No evidence text available
26344197
PRPF8 binds PRPF3, U2AF1, and SF3B1. 1 / 1
| 1
sparser
"Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, xref )."
28703423
SNW1 affects PRPF8
7 | 1 1
SNW1 binds PRPF8. 8 / 8
7 | 1
biogrid
No evidence text available
12840015
biogrid
No evidence text available
37071682
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No evidence text available
26344197
biogrid
No evidence text available
35831314
biogrid
No evidence text available
20467437
reach
"Moreover, the clip of PRP2 replaced SNIP1 by interacting with the α3 helix of SKIP, whereas new interactions between PRP2 , SKIP and PRP8 replace those between BUD13 and SKIP in the B complex (Fig. 3a and Extended Data Fig. 4c,d)."
37165190
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
SNW1 binds CWC15 and PRPF8. 1 / 1
| 1
sparser
"Finally, PPIG interacts with SNW1, CWC15, and PRPF8, all through the isomerase domain ( xref )."
30518120
PRPF19 affects PRPF8
8 | 1
PRPF19 binds PRPF8.
8 |
PRPF19 binds PRPF8. 8 / 8
8 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
26344197
biogrid
No evidence text available
34079125
biogrid
No evidence text available
22365833
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22365833
biogrid
No evidence text available
33961781
biogrid
No evidence text available
22939629
PRPF19 ubiquitinates PRPF8.
| 1
PRPF19 ubiquitinates PRPF8. 1 / 1
| 1
sparser
"On the other hand, ubiquitination of PRP8 at the C-terminal by PRP19 was not as significant and PRP4B kinase and USP39 were not ubiquitinated by PRP19."
28088760
SNRNP200 affects EFTUD2
| 1 7
PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
sparser
"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
34131137
sparser
"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
sparser
"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
sparser
"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
26392272
reach
"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
25450007
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
PRPF8 affects TP53
2 | 5 1
PRPF8 binds TP53.
2 | 1
PRPF8 binds TP53. 3 / 3
2 | 1
sparser
"The association of TP53 and PRPF8 is of particular interest considering their genomic proximity (both mapping to 17p) and the appearance of RS in cases without SF3B1 mutations and high-risk features. xref When we performed a sub-analysis of RNA splicing and GE of patients with single PRPF8 (n = 34), SF3B1 (n = 281), and TP53 (n = 52) mutations, we found high covariance features for the alpha-globin ( HBA2 ) gene, which was previously shown to correlate with impaired erythrocyte maturation in SF3B1 mutant MDS. xref Furthermore, by applying gene set overrepresentation analysis to PRPF8 and TP53 mutants, we clustered the top five categories (FDR< 0.001) in erythrocytes differentiation (KLF1 and EPB42), homeostasis, and development (ALAS2, GATA1, RHAG, and SLC4A1) suggesting that these genes might inversely correlate with HBA2 expression and be responsible for the formation of RS in SF3B1 wild-type cases ( data not shown )."
36926651
biogrid
No evidence text available
32807901
biogrid
No evidence text available
31152661
PRPF8 activates TP53.
| 3
PRPF8 activates TP53. 3 / 3
| 3
reach
"Strikingly, silencing of p53 rescues PRPF8 KD-induced apoptosis, indicating that PRPF8 KD triggers hESC apoptosis through activating the p53 pathway."
37357506
reach
"PRPF8 controls alternative splicing of PIRH2 to modulate the p53 pathway and survival of human ESCs."
37357506
reach
"In search for the mechanism by which p53 pathway is activated by PRPF8 KD, we find that PRPF8 KD alters alternative splicing of many genes, including PIRH2 which encodes an E3 ubiquitin ligase of p53."
37357506
PRPF8 inhibits TP53.
| 2
PRPF8 inhibits TP53. 2 / 2
| 2
reach
"PRPF8 knockdown (KD) induces p53 protein accumulation and activates the p53 pathway, leading to apoptosis in hESCs."
37357506
reach
"Mechanistically, loss of function mutations in zebrafishPRPF8 have been shown to result in missplicing of TP53, 36 while PRPF8 knockdown in mammalian cells led to increased compensatory transcriptional activity of TP53, 39 suggesting another possibility of synergetic interaction between PRPF8 defects and TP53."
24781015
PRPF8 affects PRPF19
8 |
PRPF19 binds PRPF8. 8 / 8
8 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
26344197
biogrid
No evidence text available
34079125
biogrid
No evidence text available
22365833
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22365833
biogrid
No evidence text available
33961781
biogrid
No evidence text available
22939629
EFTUD2 affects SNRNP200
| 1 7
PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
sparser
"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
34131137
sparser
"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
sparser
"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
sparser
"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
sparser
"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
26392272
reach
"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
25450007
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
Rep affects PRPF8
6 | 1
Rep binds PRPF8. 6 / 6
6 |
biogrid
No evidence text available
34709727
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
34901782
biogrid
No evidence text available
34901782
biogrid
No evidence text available
36180527
biogrid
No evidence text available
34901782
PRPF8 binds rep. 1 / 1
| 1
sparser
"A Jab1/MPN domain resides in the C-terminal region of PRPF8, which interacts with the SNRNP200 helicase to regulate U4/U6 snRNA duplex unwinding during B complex activation ( xref ; xref , xref ; xref )."
34395430
SNRPD2 affects PRPF8
7 |
PRPF8 binds SNRPD2. 7 / 7
7 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
biogrid
No evidence text available
39358380
biogrid
No evidence text available
35271311
SLU7 affects PRPF8
4 | 2 1
SLU7 binds PRPF8.
4 | 1 1
PRPF8 binds SLU7. 6 / 6
4 | 1 1
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
sparser
"Using sorted germ cells from Cwf19l2 ‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2 ‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure  xref )."
38889293
reach
"Using sorted germ cells from Cwf19l2‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure 6F)."
38889293
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
SLU7 decreases the amount of PRPF8.
| 1
SLU7 decreases the amount of PRPF8. 1 / 1
| 1
reach
"Although the mRNA expression levels of Prpf8, Slu7, and Prpf43 did not significantly differ between Cwf19l2‐SKO and control mice (Figure 6D), immunoblotting revealed normal SLU7 expression, slightly reduced PRPF8 expression, and moderately reduced PRPF43 expression in Cwf19l2‐SKO testes at both PD6 and PD10 (Figure 6E; Figure S8A, Supporting Information)."
38889293
SERPINB2 affects PRPF8
2 1 | 2 2
SERPINB2 binds PRPF8. 7 / 7
2 1 | 2 2
sparser
"Co-immunoprecipitation experiments confirmed that PAI-2 could interact with PRPF8 in vivo."
15346200
reach
"Co-immunoprecipitation experiments confirmed that PAI-2 could interact with PRPF8 in vivo."
15346200
reach
"PAI-2 could bind PRPF8 C-terminal in both the inside and outside of nuclear."
15346200
sparser
"PAI-2 could bind PRPF8 C-terminal in both the inside and outside of nuclear."
15346200
hprd
No evidence text available
15346200
biogrid
No evidence text available
15346200
biogrid
No evidence text available
15346200
RPAP3 affects PRPF8
3 | 1 3
PRPF8 binds RPAP3. 7 / 7
3 | 1 3
biogrid
No evidence text available
34079125
sparser
"When ZNHIT2 is knocked out, the interactions between RPAP3-EFTUD2 and RPAP3-PRPF8 were absent [ xref ]."
36008939
reach
"This demonstrated that the interaction between PRPF8 and RPAP3 can take place in the cytoplasm and is independent of EFTUD2."
28515276
sparser
"This demonstrated that the interaction between PRPF8 and RPAP3 can take place in the cytoplasm and is independent of EFTUD2."
28515276
biogrid
No evidence text available
28515276
sparser
"Hsp90 was also shown to mediate the interaction between PRPF8 and cytoplasmic RPAP3 [ xref ]."
36008939
biogrid
No evidence text available
28515276
PRPF8 affects rep
6 | 1
Rep binds PRPF8. 6 / 6
6 |
biogrid
No evidence text available
34709727
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
34901782
biogrid
No evidence text available
34901782
biogrid
No evidence text available
36180527
biogrid
No evidence text available
34901782
PRPF8 binds rep. 1 / 1
| 1
sparser
"A Jab1/MPN domain resides in the C-terminal region of PRPF8, which interacts with the SNRNP200 helicase to regulate U4/U6 snRNA duplex unwinding during B complex activation ( xref ; xref , xref ; xref )."
34395430
PRPF8 affects SNRPD2
7 |
PRPF8 binds SNRPD2. 7 / 7
7 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
22939629
biogrid
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35271311
PRPF8 affects SERPINB2
2 1 | 2 2
SERPINB2 binds PRPF8. 7 / 7
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"Co-immunoprecipitation experiments confirmed that PAI-2 could interact with PRPF8 in vivo."
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"Co-immunoprecipitation experiments confirmed that PAI-2 could interact with PRPF8 in vivo."
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"PAI-2 could bind PRPF8 C-terminal in both the inside and outside of nuclear."
15346200
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"PAI-2 could bind PRPF8 C-terminal in both the inside and outside of nuclear."
15346200
hprd
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15346200
PRPF8 affects RPAP3
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"When ZNHIT2 is knocked out, the interactions between RPAP3-EFTUD2 and RPAP3-PRPF8 were absent [ xref ]."
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"This demonstrated that the interaction between PRPF8 and RPAP3 can take place in the cytoplasm and is independent of EFTUD2."
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"This demonstrated that the interaction between PRPF8 and RPAP3 can take place in the cytoplasm and is independent of EFTUD2."
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"Hsp90 was also shown to mediate the interaction between PRPF8 and cytoplasmic RPAP3 [ xref ]."
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PRPF8 affects PRPF4
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26344197
PRPF8 affects MT-ATP6
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PRPF8 activates MT-ATP6.
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"Thus, myelinosomes called “membrane swirls” were found in cone photoreceptors of a rodent model of RP caused by the mutation in PRPC8 gene (encoding the pre-mRNA processing factor 8 that is the homolog of yeast Prp8) (To et al., 2004)."
36254982
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"Interestingly , while Snu114p / EFTUD2 interacts with both Brr2p / SNRNP200 and Prp8p / PRPF8 , EFTUD2 is associated with a craniofacial phenotype while SNRNP200 and PRPF8 both cause RP ( Figure 1 ) ."
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"The spliceosome is composed of 5 small nuclear RNAs (snRNAs), U1–U5, and many proteins including pre-mRNA splicing factors PRPF3, PRPF4, PRPF6, PRPF8, and SNRNP200, all of which are also genetic causes of RP (Ruzickova and Stanek, 2016)."
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"Several of the RP-causing PRPF8 missense mutations have been recapitulated in model organisms."
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"PRPF8-mediated RP is a result of ciliary dysfunctioning."
35791117
PRPF8 binds MT-ATP6.
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Bloc1s3 binds MT-ATP6, PRPF8, and PRP8. 2 / 2
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"Thus the Prp8p-Aar2p complex that accumulates in the prp8-rp mutants is nuclear and therefore, unlike the situation with ΔNLS-Prp8p, has the possibility to interact with Brr2p but does so with reduced efficiency as a consequence of the poor association of Brr2p with Prp8-rp mutant proteins."
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"Compared to wild-type Prp8p ( xref ), the Prp8-rp mutant proteins were associated with less Brr2p ( xref , lanes 1-7) and with more Aar2p ( xref , lanes 9-13)."
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PRPF8 affects EAPP
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PRPF8 affects CDC5L
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PRPF8 affects BCAS2
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PRPF4 affects PRPF8
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26344197
EFTUD2 affects PRPF8, and SNRNP200
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PRPF8 binds EFTUD2 and SNRNP200. 7 / 7
| 1 6
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"Remarkably, the GFP-ZNHIT2 SILAC IP revealed a strong association of this factor with EFTUD2, PRPF8, and SNRNP200."
28515276
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"Specifically, TSSC4 interacts with U5-specific proteins PRPF8, EFTUD2 and SNRNP200."
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"Importantly, our results suggest that components of Complex B, and more specifically BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP complex [ xref ], phenocopy PRPF8 most strongly."
26392272
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"AAR2, ZNHIT2, and the HSP90/R2TP complex associate with the U5-specific proteins EFTUD2, PRPF8, and SNRNP200."
28515276
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"Similarly, in humans, yeast two-hybrid and in vitro binding assays have demonstrated physical interactions between EFTUD2, SNRNP200 and PRPF8 proteins ( xref , xref ), and these interactions have been confirmed by recent cryo-EM structures of the human U4/U6."
33584830
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"Notably, depletion of the spliceosome components BRR2 and EFTUD2, which interact directly with PRPF8 to form the U5 snRNP [ xref ], most strongly phenocopy PRPF8 deficiency (Fig.  xref ; Additional file xref b, c)."
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"In addition to the PRPF8, EFTUD2, and SNRNP200 complex, our proteomics analysis as well as previous analyses found that SNW1 was in complex with another splicing subcomplex, PRP19 complex."
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EAPP affects PRPF8
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CDC5L affects PRPF8
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BCAS2 affects PRPF8
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Bisphenol A affects PRPF8
6 |
Bisphenol A increases the amount of PRPF8.
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Bisphenol A increases the amount of PRPF8. 4 / 4
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ctd
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Bisphenol A decreases the amount of PRPF8.
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Bisphenol A decreases the amount of PRPF8. 2 / 2
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36041667
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31675489
TXNL4A affects PRPF8
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"In the U4/U6.U5 tri-snRNP, DIM1 binds similar PRP8 and PRP8 interfaces as the CD2BP2 ‘Hook’ in the U5 snRNP (Fig. 2d)."
38467876
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"However, DIM1 binds an altered conformation of the PRP8 α-finger in the U4/U6.U5 tri-snRNP, which forms an extended α-helix (Fig. 2e)."
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TSSC4 affects PRPF8
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SRRM2 affects PRPF8
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"FBN2-FLNA , PRPF8-SRRM2 , and SRRM2-MKI67 all have positive patch correlation."
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26344197
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"When comparing the patch correlation of both cell populations, both SRRM2-PRPF8 and IGF2R-PRPF8 pairs show significant differences ( xref E)."
37323566
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"Module M1 includes gene pairs whose protein products are known to interact, e.g., FASN-SPTBN1 xref and PRPF8-SRRM2 xref , xref ."
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SNRPE affects PRPF8
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SNRPB affects PRPF8
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SF3B2 affects PRPF8
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22365833
PRPF8 affects apoptotic process
| 6
PRPF8 inhibits apoptotic process.
| 4
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"In ovarian cancer, PRPF8 expression significantly promotes ovarian cancer cell proliferation and inhibits apoptosis through the circRNA-UBAP2/miR-382-5p/PRPF8 pathway [69]."
40136404
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"CircRNA-UBAP2 can be used as a ceRNA of spongy miR-382-5p in ovarian cancer, increasing the expression level of PRPF8, promoting the proliferation of ovarian cancer cells, and inhibiting cell apoptosis (Xu et al., 2020)."
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"Consequently, circRNA-UBAP2 upregulated expression level of PRPF8 by sponged miR-382-5p acted as a ceRNA, promoted proliferation and inhibited apoptosis in ovarian cancer cells."
32690086
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"Knockdown of pan-cancer drivers PRPF8 caused cell apoptosis in breast cancer, which dedicated that PRPF8 is a proto-oncogene regulating cell viability [10]."
32690086
PRPF8 activates apoptotic process.
| 2
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| 2
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"Strikingly, silencing of p53 rescues PRPF8 KD-induced apoptosis, indicating that PRPF8 KD triggers hESC apoptosis through activating the p53 pathway."
37357506
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"Expression of pathogenic PRPF8 variants responsible for retinitis pigmentosa induced apoptosis [61]."
36560714
PRPF8 affects TXNL4A
4 | 2
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"In the U4/U6.U5 tri-snRNP, DIM1 binds similar PRP8 and PRP8 interfaces as the CD2BP2 ‘Hook’ in the U5 snRNP (Fig. 2d)."
38467876
reach
"However, DIM1 binds an altered conformation of the PRP8 α-finger in the U4/U6.U5 tri-snRNP, which forms an extended α-helix (Fig. 2e)."
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33961781
PRPF8 affects TSSC4
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PRPF8 affects SRRM2
3 | 3
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"FBN2-FLNA , PRPF8-SRRM2 , and SRRM2-MKI67 all have positive patch correlation."
37323566
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26344197
sparser
"When comparing the patch correlation of both cell populations, both SRRM2-PRPF8 and IGF2R-PRPF8 pairs show significant differences ( xref E)."
37323566
sparser
"Module M1 includes gene pairs whose protein products are known to interact, e.g., FASN-SPTBN1 xref and PRPF8-SRRM2 xref , xref ."
36747718
PRPF8 affects SNRPE
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PRPF8 affects SNRPB
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PRPF8 affects SLU7
4 | 1 1
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"Using sorted germ cells from Cwf19l2 ‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2 ‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure  xref )."
38889293
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"Using sorted germ cells from Cwf19l2‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure 6F)."
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PRPF8 affects SF3B2
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22365833
PRPF8 affects CCP110
| 5 1
PRPF8 activates CCP110.
| 4
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"PRPF8 promotes CP110 removal to initiate ciliogenesis by binding to the linear ubiquitin chains."
34813648
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"Subsequently, PRPF8 at the distal end of the mother centriole interacts with the linear ubiquitin chains of CP110 and promotes the removal of CP110 from the mother centriole, thus initiating ciliogenesis (Fig. 7 G)."
34813648
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"At the beginning of ciliogenesis, PRPF8 serves as the receptor for linear ubiquitin chains of CP110 and disappears from the mother centriole to promote CP110 removal."
34813648
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"Strikingly, depletion of PRPF8 in RPE-1 cells dramatically suppressed CP110 removal from the mother centrioles after serum starvation and significantly inhibited ciliogenesis (Fig. 5, C–E; and Fig. S5 C)."
34813648
PRPF8 binds CCP110.
| 1 1
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| 1 1
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"Thus, LUBAC-catalyzed linear ubiquitin chains construct a CP110–PRPF8 complex in which PRPF8 takes CP110 away from the mother centriole to promote ciliogenesis."
34813648
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"Thus, LUBAC-catalyzed linear ubiquitin chains construct a CP110–PRPF8 complex in which PRPF8 takes CP110 away from the mother centriole to promote ciliogenesis."
34813648
PRPF8 affects AR
3 | 2 1
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26371515
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"PRPF8 interacts with the androgen receptor, regulating its function in prostate cancer cells and controlling its transcriptional activity."
40136404
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"Splicing Factor Prp8 Interacts With NES (AR) and Regulates Androgen Receptor in Prostate Cancer Cells."
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35785414
PRPF8 ubiquitinates AR.
| 1
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| 1
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"As an evidence, the downregulation of Prp8 is reported to increase the nuclear enrichment of AR tagged with GFP, decrease its transcriptional activity, and enhance the polyubiquitination of AR [85] ."
29107180
NPAT affects PRPF8
| 6
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| 6
sparser
"Despite only partial conservation of the C-terminus, both human and mouse p57 KIP2 are similarly effective in blocking p220 NPAT phosphorylation ( xref )."
19170105
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"Hence, our data suggest that the selective ability of human p57 KIP2 to prevent p220 NPAT phosphorylation is mediated in part by its unique C-terminus."
19170105
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"Both human and mouse wild type proteins are equally effective in blocking p220 NPAT phosphorylation ( xref )."
19170105
sparser
"We tested the specificity of p57 KIP2 to block p220 NPAT phosphorylation at subnuclear foci using p57 KIP2 mutants ( xref )."
19170105
sparser
"The data indicate that p220 NPAT phosphorylation may occur despite a reduction in cellular CDK kinase activity upon elevation of p21 CIP1/WAF1 levels."
19170105
sparser
"Our data suggest that p57 KIP2 is more effective in blocking p220 NPAT phosphorylation in situ than the other two CKIs."
19170105
DHX15 affects PRPF8
3 | 2 1
DHX15 binds PRPF8.
3 | 1 1
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3 | 1 1
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"Using sorted germ cells from Cwf19l2 ‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2 ‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure  xref )."
38889293
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"Using sorted germ cells from Cwf19l2‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure 6F)."
38889293
DHX15 increases the amount of PRPF8.
| 1
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| 1
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"Although the mRNA expression levels of Prpf8, Slu7, and Prpf43 did not significantly differ between Cwf19l2‐SKO and control mice (Figure 6D), immunoblotting revealed normal SLU7 expression, slightly reduced PRPF8 expression, and moderately reduced PRPF43 expression in Cwf19l2‐SKO testes at both PD6 and PD10 (Figure 6E; Figure S8A, Supporting Information)."
38889293
USP39 affects PRPF8
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TP53 affects PRPF8
2 | 2 1
TP53 binds PRPF8.
2 | 1
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"The association of TP53 and PRPF8 is of particular interest considering their genomic proximity (both mapping to 17p) and the appearance of RS in cases without SF3B1 mutations and high-risk features. xref When we performed a sub-analysis of RNA splicing and GE of patients with single PRPF8 (n = 34), SF3B1 (n = 281), and TP53 (n = 52) mutations, we found high covariance features for the alpha-globin ( HBA2 ) gene, which was previously shown to correlate with impaired erythrocyte maturation in SF3B1 mutant MDS. xref Furthermore, by applying gene set overrepresentation analysis to PRPF8 and TP53 mutants, we clustered the top five categories (FDR< 0.001) in erythrocytes differentiation (KLF1 and EPB42), homeostasis, and development (ALAS2, GATA1, RHAG, and SLC4A1) suggesting that these genes might inversely correlate with HBA2 expression and be responsible for the formation of RS in SF3B1 wild-type cases ( data not shown )."
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31152661
TP53 inhibits PRPF8.
| 2
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| 2
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"For correct determination of the IPSS-R score FISH for MECOM rearrangements should be included.OTHER RECURRENT FOCAL COPY NUMBER ABNORMALITIES IN MDSGenetic abnormalityNF1 loss RUNX1 loss RASSF1 loss CCND1 loss TET2 loss DNMT3A loss HRAS loss PDGFRA loss FIP1L1 loss ASXL1 loss ETV6 loss EZH2 loss KRAS loss NCOR2 loss NPM1 loss PRPF8 loss TP53 lossPrognostic impact not known locusReference17q11 21q22 3p21 11q13 4q24 2p23 11p15 4q12 4q12 20q11 12p13 7q36 12p12 12q24 5q35 17p13 17p13 (Kolquist et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011; Thiel et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011) (Kolquist et al., 2011) (Kolquist et al., 2011; Thiel et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011) (Kolquist et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011) (Kolquist et al., 2011) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) Genes, Chromosomes & Cancer DOI 10.1002/gcc ARRAY GUIDELINES FOR HAEMATOLOGICAL NEOPLASIA489REFERENCESAffer M, Chesi M, Chen WD, Keats JJ, Demchenko YN, Tamizhmani K, Garbitt VM, Riggs DL, Brents LA, Roschke AV, Van Wier S, Fonseca R, Bergsagel PL, Kuehl WM. 2014."
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"Strikingly, silencing of p53 rescues PRPF8 KD-induced apoptosis, indicating that PRPF8 KD triggers hESC apoptosis through activating the p53 pathway."
37357506
SNRPF affects PRPF8
5 |
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SNRPD3 affects PRPF8
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SF3B1 affects PRPF8
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No evidence text available
22939629
biogrid
No evidence text available
28515276
PRPF8 binds PRPF3, U2AF1, and SF3B1. 1 / 1
| 1
sparser
"Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, xref )."
28703423
SF3A1 affects PRPF8
5 |
PRPF8 binds SF3A1. 5 / 5
5 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35271311
biogrid
No evidence text available
34079125
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
RUVBL2 affects PRPF8
5 |
RUVBL2 binds PRPF8. 5 / 5
5 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35271311
biogrid
No evidence text available
34079125
RNF113A affects PRPF8
1 | 4
RNF113A activates PRPF8.
| 3
RNF113A activates PRPF8. 3 / 3
| 3
reach
"Cwc24 modulates the interaction of Prp8 with the 5' splice site."
31504764
reach
"Nevertheless, Prp8 crosslinking was more specific in the presence of Cwc24 (lane 8), and spread through positions -3 to -9 in the absence of Cwc24 (lane 7) (tracing of lanes 7 and 8 shown in Supplementary Figure S2), suggesting that Cwc24 may promote specific interactions of Prp8 with the 5′ splice site.Interestingly, our previous study demonstrated that Prp8 and Cwc24 displayed major crosslinks at positions +1 and +2 of the 5′ splice site on post-activation spliceosomes (32)."
31504764
reach
"The absence of NTC or Cwc24 allows Prp8 to interact immediately with the 5′ splice site upon the release of U4, but results in mislocalization of U5 and U6 on the 5′ splice site.A model for how Cwc24 may mediate formation of the RNA catalytic core through Prp2-mediated spliceosome remodeling is presented in Figure 8. Upon the release of U4, Cwc24 may bind onto the 5′ splice site immediately upon the binding of NTC, with its ZF-domain contacting the +1 and +2 positions of the intron."
31504764
RNF113A inhibits PRPF8.
| 1
RNF113A inhibits PRPF8. 1 / 1
| 1
reach
"Interestingly, Prp8 was not detected to crosslink to the 5′ splice site on the Cwc24-associated spliceosomes, except for rather weak crosslinks at the -5 and -6 positions, indicating that the presence of Cwc24 prevents Prp8 from contacting the 5′ splice site on activated spliceosomes."
31504764
RNF113A binds PRPF8.
1 |
RNF113A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35819319
RBM22 affects PRPF8
2 | 1 2
PRPF8 binds RBM22. 4 / 4
2 | 1 1
biogrid
No evidence text available
34079125
sparser
"This is in agreement with the association of PRPF8 and RBM22 with intron lariats as part of the human catalytic step I spliceosome xref ."
31570875
reach
"BEDtools also cannot show regions of unfavorable binding (the correlation is always positive) or differentiate between upstream and downstream binding geometries.The resolution limit of BEDtools is apparent when observing the binding of PRPF8, RBM22, U2AF2, and BUD13: PRPF8 and RBM22 appear to bind close to each other and U2AF2 and BUD13 bind close to each other as expected (Figures S8H and S8I); however, there is minimal difference in the correlation of U2AF2 with BUD13 versus U2AF2 with PRPF8 or RBM22 (Figure S8I), even though PRPF8 and RBM22 are known to generally bind further from U2AF2 than BUD13."
35474897
biogrid
No evidence text available
28515276
TPS-sab binds RBM22 and PRPF8. 1 / 1
| 1
sparser
"At 5’ SSs, RBM22 and PRPF8 were bound at the exonic end, which has been shown to be critical for splicesome assembly [ xref , xref ]."
32584815
R2TP affects PRPF8
| 5
R2TP binds PRPF8. 4 / 4
| 4
sparser
"PRPF8 also associates with R2TP mostly by the direct interaction with the RUVBL1–RUVBL2 complex, but the in vitro pull-down experiments and the mass spectrometry in cells suggest that RPAP3-PIH1D1 also contributes to bring PRPF8 to the R2TP complex."
34951455
sparser
"We then analyzed if PRPF8 could also interact with the other components of R2TP using the same methodology PRPF8 interacted directly with RPAP3-PIH1D1 in the presence and absence of RUVBL1–RUVBL2 (Figure xref , top panels, xref ) and this was confirmed when pulling down from GST-RPAP3 pull-down (Figure xref , bottom panels)."
34951455
sparser
"PRPF8 can interact with R2TP without the help of any additional factor, at least in vitro ."
34951455
sparser
"S2118F and H2309R mutations both increased the association of PRPF8 with R2TP ( xref ) and also with ZNHIT2 ( xref )."
28515276
R2TP binds PRPF8 and EFTUD2. 1 / 1
| 1
sparser
"Depletion of U5 proteins and PRPF8 RP mutation both increase the association of PRPF8 and EFTUD2 with R2TP."
28515276
PRPF8
3 | 1 1
PRPF8 binds.
3 | 1
PRPF8 binds PRPF8. 4 / 4
3 | 1
biogrid
No evidence text available
17317632
biogrid
No evidence text available
16723661
reach
"In addition, we found increased binding of PRPF8 to C/D and H/ACA box snoRNAs in RP13 retinal cells."
38605034
biogrid
No evidence text available
28515276
PRPF8 translocates.
| 1
PRPF8 translocates to the membrane. 1 / 1
| 1
sparser
"Besides the loss-of-function approaches, transfection experiments showed that pEP84R is able to recruit pp220 to perinuclear ER and Golgi membranes, where pEP84R preferentially targets."
36716344
PRPF8 affects cell death
| 5
PRPF8 activates cell death.
| 3
PRPF8 activates cell death. 3 / 3
| 3
reach
"In Drosophila, loss of PRPF8 decreases cell proliferation, increases cell death and modulates cell differentiation and polarity, and PRPF8-mediated hyperplastic growth is induced by different oncogenes ."
36609600
reach
"Knockdown of c-MYC attenuated cell death caused by depletion of PRPF8 or SF3B1 in SCCRDEBMet cells and depletion of PRPF8 in SCCRDEB4 cells."
29796170
reach
"Knockdown of SF3B1, PRPF8, UBL5 and USP39 increased cell death in all cSCC cell lines."
29796170
PRPF8 inhibits cell death.
| 2
PRPF8 inhibits cell death. 2 / 2
| 2
reach
"Our results support these findings, as depleting PRPF8 led to enhanced annexin V staining (Figure 2B) and enhanced cell death (Figure 2C) in uninfected cells."
36560714
reach
"In colorectal cancer, Abdel-Wahab et al. demonstrated that silencing PRPF8 in DLD1 colon cancer cells led to cell death, indicating that PRPF8 regulates both cell growth and apoptosis in colorectal cancer [51]."
40136404
PRPF8 affects USP39
5 |
USP39 binds PRPF8. 5 / 5
5 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
37071682
biogrid
No evidence text available
40437099
biogrid
No evidence text available
19615732
biogrid
No evidence text available
35271311
PRPF8 affects SNRPF
5 |
SNRPF binds PRPF8. 5 / 5
5 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35271311
biogrid
No evidence text available
28514442
biogrid
No evidence text available
35271311
PRPF8 affects SNRPD3
5 |
PRPF8 binds SNRPD3. 5 / 5
5 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28515276
PRPF8 affects SF3B1
4 | 1
PRPF8 binds SF3B1. 4 / 4
4 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
35271311
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
PRPF8 binds PRPF3, U2AF1, and SF3B1. 1 / 1
| 1
sparser
"Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, xref )."
28703423
PRPF8 affects SF3A1
5 |
PRPF8 binds SF3A1. 5 / 5
5 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35271311
biogrid
No evidence text available
34079125
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
PRPF8 affects RUVBL2
5 |
RUVBL2 binds PRPF8. 5 / 5
5 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35271311
biogrid
No evidence text available
34079125
PRPF8 affects RBM22
2 | 1 2
PRPF8 binds RBM22. 4 / 4
2 | 1 1
biogrid
No evidence text available
34079125
sparser
"This is in agreement with the association of PRPF8 and RBM22 with intron lariats as part of the human catalytic step I spliceosome xref ."
31570875
reach
"BEDtools also cannot show regions of unfavorable binding (the correlation is always positive) or differentiate between upstream and downstream binding geometries.The resolution limit of BEDtools is apparent when observing the binding of PRPF8, RBM22, U2AF2, and BUD13: PRPF8 and RBM22 appear to bind close to each other and U2AF2 and BUD13 bind close to each other as expected (Figures S8H and S8I); however, there is minimal difference in the correlation of U2AF2 with BUD13 versus U2AF2 with PRPF8 or RBM22 (Figure S8I), even though PRPF8 and RBM22 are known to generally bind further from U2AF2 than BUD13."
35474897
biogrid
No evidence text available
28515276
TPS-sab binds RBM22 and PRPF8. 1 / 1
| 1
sparser
"At 5’ SSs, RBM22 and PRPF8 were bound at the exonic end, which has been shown to be critical for splicesome assembly [ xref , xref ]."
32584815
PRPF8 affects R2TP
| 5
R2TP binds PRPF8. 4 / 4
| 4
sparser
"PRPF8 also associates with R2TP mostly by the direct interaction with the RUVBL1–RUVBL2 complex, but the in vitro pull-down experiments and the mass spectrometry in cells suggest that RPAP3-PIH1D1 also contributes to bring PRPF8 to the R2TP complex."
34951455
sparser
"We then analyzed if PRPF8 could also interact with the other components of R2TP using the same methodology PRPF8 interacted directly with RPAP3-PIH1D1 in the presence and absence of RUVBL1–RUVBL2 (Figure xref , top panels, xref ) and this was confirmed when pulling down from GST-RPAP3 pull-down (Figure xref , bottom panels)."
34951455
sparser
"PRPF8 can interact with R2TP without the help of any additional factor, at least in vitro ."
34951455
sparser
"S2118F and H2309R mutations both increased the association of PRPF8 with R2TP ( xref ) and also with ZNHIT2 ( xref )."
28515276
R2TP binds PRPF8 and EFTUD2. 1 / 1
| 1
sparser
"Depletion of U5 proteins and PRPF8 RP mutation both increase the association of PRPF8 and EFTUD2 with R2TP."
28515276
PRPF8 affects PCBP1
5 |
PRPF8 binds PCBP1. 5 / 5
5 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
PRPF8 affects MYC
5 |
MYC binds PRPF8. 5 / 5
5 |
biogrid
No evidence text available
17353931
biogrid
No evidence text available
29467282
biogrid
No evidence text available
35013218
biogrid
No evidence text available
36424410
biogrid
No evidence text available
30415952
PRPF8 affects DHX15
3 | 1 1
DHX15 binds PRPF8. 5 / 5
3 | 1 1
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
sparser
"Using sorted germ cells from Cwf19l2 ‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2 ‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure  xref )."
38889293
biogrid
No evidence text available
35831314
reach
"Using sorted germ cells from Cwf19l2‐SKO and control mice, co‐IP assays showed PRPF8 specifically co‐precipitated with both PRPF43 and SLU7 in controls, while in Cwf19l2‐SKO mice, the interaction between PRPF8 and SLU7 was detectable, but the interaction between PRPF8 and PRPF43 was barely noticeable (Figure 6F)."
38889293
PRPF8 affects Cell Survival
| 4 1
PRPF8 activates Cell Survival. 5 / 5
| 4 1
reach
"Downregulation of PRPF8 promoted increased cell viability, proliferation, and clonogenicity of K-562 chronic myelogenous cells (CML) supporting PRPF8 as a tumor suppressor."
28888996
eidos
"Upregulation of Prp8 promoted cell viability and migration in a human hepatic astrocyte line ."
32547101
eidos
"Functionally , the loss of Prp8 may specifically inhibit cell viability and metastasis and activated EMT and PI3K / Akt in HCC cells ."
32547101
eidos
"The upregulation of Prp8 promoted cell viability , metastasis and the activity of the PI3K / Akt pathway in hepatic astrocytes cells and HCC cells ."
32547101
eidos
"Upregulation of Prp8 promoted cell viability and migration in HCC cells ."
32547101
PCBP1 affects PRPF8
5 |
PRPF8 binds PCBP1. 5 / 5
5 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
MYC affects PRPF8
5 |
MYC binds PRPF8. 5 / 5
5 |
biogrid
No evidence text available
17353931
biogrid
No evidence text available
29467282
biogrid
No evidence text available
35013218
biogrid
No evidence text available
36424410
biogrid
No evidence text available
30415952
AR affects PRPF8
3 | 1 1
AR binds PRPF8. 5 / 5
3 | 1 1
biogrid
No evidence text available
26371515
sparser
"PRPF8 interacts with the androgen receptor, regulating its function in prostate cancer cells and controlling its transcriptional activity."
40136404
reach
"Splicing Factor Prp8 Interacts With NES (AR) and Regulates Androgen Receptor in Prostate Cancer Cells."
26371515
biogrid
No evidence text available
32814769
biogrid
No evidence text available
35785414
Sodium arsenite affects PRPF8
4 |
Sodium arsenite increases the amount of PRPF8.
2 |
Sodium arsenite increases the amount of PRPF8. 2 / 2
2 |
ctd
No evidence text available
36209798
ctd
No evidence text available
39836092
Sodium arsenite decreases the amount of PRPF8.
2 |
Sodium arsenite decreases the amount of PRPF8. 2 / 2
2 |
ctd
No evidence text available
39836092
ctd
No evidence text available
38568856
Cisplatin affects PRPF8
| 4
Cisplatin binds PRPF8.
| 3
reach
"A likewise interaction has also been found in Prp8-cisplatin complex [ 97 ]."
33727137
reach
"Mass spectrometric analysis unequivocally supported the previous data and ruled out the role of TCEP in cisplatin interaction with prp8 intein."
33727137
reach
"Similar to RecA-cisplatin complex, two cisplatin molecules in a completely dissociated form in the Prp8-cisplatin complex were found [ 64 , 97 ]."
33727137
Cisplatin inhibits PRPF8.
| 1
Cisplatin inhibits PRPF8. 1 / 1
| 1
reach
"Cisplatin also inhibits the C. neoformans Prp8 intein splicing with IC 50 of 2.5 µM in an in vitro splicing assay based on split Renilla luciferase; and the MIC 90 was 4.5-20 μg/ml in various strains of C. neoformans and C. gattii ."
35211511
ZNHIT2 affects PRPF8
3 | 1
ZNHIT2 binds PRPF8. 4 / 4
3 | 1
reach
"ZNHIT2, ECD, AAR2 and PRPF8 can form complexes with R2TP."
34951455
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
WDR83 affects PRPF8
4 |
PRPF8 binds WDR83. 4 / 4
4 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
SNRPD1 affects PRPF8
4 |
PRPF8 binds SNRPD1. 4 / 4
4 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
SHOX affects PRPF8
| 4
PRPF8 binds SHOX. 4 / 4
| 4
reach
"Prp8 then binds to the 3′SS while retaining interaction with the 5′-exon for exon ligation."
30395327
reach
"Our results show that Prp8 directly binds over the 5′SS and the BS during the first catalytic step, and over the 5′SS and 3′SS during the second step."
30395327
reach
"For pre-mRNA transcripts, PRPF8 preferentially bound to the 5’SS of pre-mRNA transcripts, consistent with previous work , but weak 5’SS were more affected by the PRPF8 p.H2309P mutation in retinal cells."
38605034
reach
"Interestingly, changes in PRPF8 binding to the affected exons with weak 5’SS were sequence-dependent (i.e., downregulated exons were cytidine-rich and upregulated exons were thymidine-rich)."
38605034
SF3B3 affects PRPF8
4 |
PRPF8 binds SF3B3. 4 / 4
4 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
RUVBL1 affects PRPF8
4 |
RUVBL1 binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
PRPF8 affects prp16-302
| 4
PRPF8 inhibits prp16-302. 4 / 4
| 4
reach
"This allowed us to analyze combinations of prp8 and U6 alleles that individually suppress prp16-302 defects to establish if they act by the same or distinct mechanisms."
38876504
reach
"We carried out a genetic screen for prp8 alleles within the Prp8 N-terminal domain that suppress cs defects of prp16-302."
38876504
reach
"Each of the prp8 alleles suppresses prp16-302 defects (Fig. 4E) to a different extent, with K603I and K611I/T exerting the strongest suppression."
38876504
reach
"Only a combination of T589P + K611I alleles does not follow this pattern as they act additively both for suppression of prp16-302 defects (Supplemental Fig. S1A) and for ts growth phenotypes (Supplemental Fig. S1B), consistent with their partial allele status.Together, we identified multiple alleles of cwc2, U6, and prp8 that suppress defects of prp16-302 and thus facilitate the first-to-second steps transition."
38876504
PRPF8 affects ZNHIT2
3 | 1
ZNHIT2 binds PRPF8. 4 / 4
3 | 1
reach
"ZNHIT2, ECD, AAR2 and PRPF8 can form complexes with R2TP."
34951455
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
PRPF8 affects WDR83
4 |
PRPF8 binds WDR83. 4 / 4
4 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
PRPF8 affects SNRPD1
4 |
PRPF8 binds SNRPD1. 4 / 4
4 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
PRPF8 affects SHOX
| 4
PRPF8 binds SHOX. 4 / 4
| 4
reach
"Prp8 then binds to the 3′SS while retaining interaction with the 5′-exon for exon ligation."
30395327
reach
"Our results show that Prp8 directly binds over the 5′SS and the BS during the first catalytic step, and over the 5′SS and 3′SS during the second step."
30395327
reach
"For pre-mRNA transcripts, PRPF8 preferentially bound to the 5’SS of pre-mRNA transcripts, consistent with previous work , but weak 5’SS were more affected by the PRPF8 p.H2309P mutation in retinal cells."
38605034
reach
"Interestingly, changes in PRPF8 binding to the affected exons with weak 5’SS were sequence-dependent (i.e., downregulated exons were cytidine-rich and upregulated exons were thymidine-rich)."
38605034
PRPF8 affects SF3B3
4 |
PRPF8 binds SF3B3. 4 / 4
4 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
PRPF8 affects RUVBL1
4 |
RUVBL1 binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
PRPF8 affects PRP8
| 4
PRPF8 binds PRP8. 2 / 2
| 2
sparser
"Thus, one major function of YJU2 and ISY1 is to stabilize the position of the U2/BS helix, which may still be flexible even after interacting with its PRP8 scaffold."
33007253
sparser
"K63-linked ubiquitylation of PRP31 by PRP19 regulates its association with PRP8 and the U5 snRNP."
35205626
Bloc1s3 binds MT-ATP6, PRPF8, and PRP8. 2 / 2
| 2
sparser
"Thus the Prp8p-Aar2p complex that accumulates in the prp8-rp mutants is nuclear and therefore, unlike the situation with ΔNLS-Prp8p, has the possibility to interact with Brr2p but does so with reduced efficiency as a consequence of the poor association of Brr2p with Prp8-rp mutant proteins."
17934474
sparser
"Compared to wild-type Prp8p ( xref ), the Prp8-rp mutant proteins were associated with less Brr2p ( xref , lanes 1-7) and with more Aar2p ( xref , lanes 9-13)."
17934474
PRPF8 affects PRP4K
4 |
PRP4K binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
biogrid
No evidence text available
23602568
biogrid
No evidence text available
35271311
PRPF8 affects PLIN2
| 4
PRPF8 activates PLIN2. 4 / 4
| 4
reach
"PRPF8 C-terminal mutations cause an early onset and severe form of adRP, and structural analysis of this region shows that it inserts into the RNA binding tunnel of the SNRNP200 helicase."
26593421
reach
"Relevant to both these interpretations is the observation that adRP linked to chromosome 17p is caused by mutations in PRPC8 (McKie et al., 2001), the human ortholog of yeast splicing factor Prp8p (Br[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11545739
reach
"In addition, both truncation and missense mutations in PRPF8 have been reported to cause adRP, but the pathogenicity of missense mutations in PRPF8 is suspicious in some cases since missense variants in PRPF8 are common based on the gnomAD database; rare damaging variants in PRPF8 had a sum allele frequency of 2.17 × 10 (614/282896), which is higher than the prevalence of RP (1/3000)."
30689892
reach
"Nine mutations, six of which are novel, in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31, causing adRP have been identified in the Spanish population."
12714658
PRPF8 affects GCFC2
3 | 1
GCFC2 binds PRPF8. 4 / 4
3 | 1
reach
"Specifically, the TFIP11–GCFC2 dimer interacts with SKIP (scPrp45), while GCFC2 directly binds to PRP8, blocking the recruitment of the RNA helicases DHX16 (scPrp2), DHX38 (scPrp16) and DHX8 (scPrp22), all of which are needed for further splicing progression (Supplementary information, Fig. S10c, d)."
40016598
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
PRPF8 affects DHX9
3 1 |
DHX9 binds PRPF8. 4 / 4
3 1 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
hprd
No evidence text available
15034300
biogrid
No evidence text available
35831314
PRPF8 affects CRNKL1
4 |
CRNKL1 binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
biogrid
No evidence text available
26344197
PRPF8 affects C9orf78
4 |
C9orf78 binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35241646
biogrid
No evidence text available
35271311
biogrid
No evidence text available
26472760
PRPF8 affects Bloc1s3
| 2 2
PRPF8 binds Bloc1s3.
| 2
Bloc1s3 binds MT-ATP6, PRPF8, and PRP8. 2 / 2
| 2
sparser
"Thus the Prp8p-Aar2p complex that accumulates in the prp8-rp mutants is nuclear and therefore, unlike the situation with ΔNLS-Prp8p, has the possibility to interact with Brr2p but does so with reduced efficiency as a consequence of the poor association of Brr2p with Prp8-rp mutant proteins."
17934474
sparser
"Compared to wild-type Prp8p ( xref ), the Prp8-rp mutant proteins were associated with less Brr2p ( xref , lanes 1-7) and with more Aar2p ( xref , lanes 9-13)."
17934474
PRPF8 activates Bloc1s3.
| 2
PRPF8 activates Bloc1s3. 2 / 2
| 2
reach
"For example, a previous study suggested that mutations in PRPF8 may cause RP by disrupting the nuclear association of Brr2p with the U5 snRNP and, consequently, the assembly of the triple snRNP."
19878916
reach
"Herein, we sought to correlate the retinal cell-type-specific disease phenotype with the splicing profile shown by a patient with autosomal recessive RP, caused by a mutation in pre-mRNA splicing factor 8 (PRPF8)."
33994920
PRP8 affects PRPF8
| 4
PRPF8 binds PRP8. 2 / 2
| 2
sparser
"Thus, one major function of YJU2 and ISY1 is to stabilize the position of the U2/BS helix, which may still be flexible even after interacting with its PRP8 scaffold."
33007253
sparser
"K63-linked ubiquitylation of PRP31 by PRP19 regulates its association with PRP8 and the U5 snRNP."
35205626
Bloc1s3 binds MT-ATP6, PRPF8, and PRP8. 2 / 2
| 2
sparser
"Thus the Prp8p-Aar2p complex that accumulates in the prp8-rp mutants is nuclear and therefore, unlike the situation with ΔNLS-Prp8p, has the possibility to interact with Brr2p but does so with reduced efficiency as a consequence of the poor association of Brr2p with Prp8-rp mutant proteins."
17934474
sparser
"Compared to wild-type Prp8p ( xref ), the Prp8-rp mutant proteins were associated with less Brr2p ( xref , lanes 1-7) and with more Aar2p ( xref , lanes 9-13)."
17934474
PRP4K affects PRPF8
4 |
PRP4K binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
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23602568
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No evidence text available
35271311
GCFC2 affects PRPF8
3 | 1
GCFC2 binds PRPF8. 4 / 4
3 | 1
reach
"Specifically, the TFIP11–GCFC2 dimer interacts with SKIP (scPrp45), while GCFC2 directly binds to PRP8, blocking the recruitment of the RNA helicases DHX16 (scPrp2), DHX38 (scPrp16) and DHX8 (scPrp22), all of which are needed for further splicing progression (Supplementary information, Fig. S10c, d)."
40016598
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
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No evidence text available
33961781
DHX9 affects PRPF8
3 1 |
DHX9 binds PRPF8. 4 / 4
3 1 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
hprd
No evidence text available
15034300
biogrid
No evidence text available
35831314
CRNKL1 affects PRPF8
4 |
CRNKL1 binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
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No evidence text available
26344197
C9orf78 affects PRPF8
4 |
C9orf78 binds PRPF8. 4 / 4
4 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35241646
biogrid
No evidence text available
35271311
biogrid
No evidence text available
26472760
ZNF830 affects PRPF8
3 |
PRPF8 binds ZNF830. 3 / 3
3 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
XAB2 affects PRPF8
2 | 1
PRPF8 binds XAB2. 3 / 3
2 | 1
reach
"First, we examined whether PRPF8 and XAB2 form a complex in the human osteosarcoma U2OS cell line, by performing co-IP analysis."
29212152
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
U2AF2 affects PRPF8
2 | 1
U2AF2 binds PRPF8. 3 / 3
2 | 1
reach
"BEDtools also cannot show regions of unfavorable binding (the correlation is always positive) or differentiate between upstream and downstream binding geometries.The resolution limit of BEDtools is apparent when observing the binding of PRPF8, RBM22, U2AF2, and BUD13: PRPF8 and RBM22 appear to bind close to each other and U2AF2 and BUD13 bind close to each other as expected (Figures S8H and S8I); however, there is minimal difference in the correlation of U2AF2 with BUD13 versus U2AF2 with PRPF8 or RBM22 (Figure S8I), even though PRPF8 and RBM22 are known to generally bind further from U2AF2 than BUD13."
35474897
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No evidence text available
35271311
biogrid
No evidence text available
26641092
TTC27 affects PRPF8
3 |
TTC27 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26472760
biogrid
No evidence text available
28515276
TCERG1 affects PRPF8
3 |
PRPF8 binds TCERG1. 3 / 3
3 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
biogrid
No evidence text available
37071682
STIP1 affects PRPF8
3 |
PRPF8 binds STIP1. 3 / 3
3 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
33239621
biogrid
No evidence text available
28515276
STAU1 affects PRPF8
3 |
STAU1 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
36232890
biogrid
No evidence text available
30948266
biogrid
No evidence text available
23125841
SNRPN affects PRPF8
3 |
SNRPN binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
SNRPG affects PRPF8
3 |
SNRPG binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
33961781
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No evidence text available
28514442
SNRPA1 affects PRPF8
3 |
PRPF8 binds SNRPA1. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
SNRNP70 affects PRPF8
3 |
PRPF8 binds SNRNP70. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
biogrid
No evidence text available
29802200
SMU1 affects PRPF8
3 |
PRPF8 binds SMU1. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
27173435
biogrid
No evidence text available
28515276
SF3B6 affects PRPF8
3 |
SF3B6 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
SF3A2 affects PRPF8
3 |
SF3A2 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
17332742
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35271311
RBM39 affects PRPF8
2 | 1
RBM39 binds PRPF8. 3 / 3
2 | 1
reach
"In addition, physical interactions between RBM39 and SF3A1/2/3, SF3B4, PRPF8 and MBNL1 have also been reported (Figure 5A) (10,83)."
36477312
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No evidence text available
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35271311
reach
"Interestingly, we found a positive association of PRPF8 with chromosomal instability, which is in line with a previous study in osteosarcoma cells wherein PRPF8 silencing induces defects in Homologous Recombination (HR) through the specific inhibition of BRCA1 [54]."
39725737
reach
"Interestingly, we found a positive association of PRPF8 with chromosomal instability, which is in line with a previous study in osteosarcoma cells wherein PRPF8 silencing induces defects in Homologous Recombination (HR) through the specific inhibition of BRCA1 [54]."
39725737
reach
"Depletion of p53 binding protein 1 (53BP1) suppressed the HR defect induced by both BRCA1 loss and PRPF8 knockdown, suggesting that PRPF8 functions during HR at least in part via facilitating BRCA1 function."
34395430
PRPF8 affects cisplatin
| 3
reach
"A likewise interaction has also been found in Prp8-cisplatin complex [ 97 ]."
33727137
reach
"Mass spectrometric analysis unequivocally supported the previous data and ruled out the role of TCEP in cisplatin interaction with prp8 intein."
33727137
reach
"Similar to RecA-cisplatin complex, two cisplatin molecules in a completely dissociated form in the Prp8-cisplatin complex were found [ 64 , 97 ]."
33727137
PRPF8 affects cilium assembly
| 3
PRPF8 activates cilium assembly. 3 / 3
| 3
reach
"These data suggest that PRPF8 regulates CP110 removal and further promotes ciliogenesis, depending on its ability to bind to the linear ubiquitin chains."
34813648
reach
"Strikingly, depletion of PRPF8 in RPE-1 cells dramatically suppressed CP110 removal from the mother centrioles after serum starvation and significantly inhibited ciliogenesis (Fig. 5, C–E; and Fig. S5 C)."
34813648
reach
"PRPF8 promotes CP110 removal to initiate ciliogenesis by binding to the linear ubiquitin chains."
34813648
reach
"3D polymerase (3D ) of EV71 entered the nucleus and targeted the central pre-mRNA processing factor 8 (Prp8) to block pre-mRNA splicing and mRNA synthesis ."
34079066
reach
"Moreover, 3Dpol, the enteroviral RNA-dependent RNA polymerase, enters the nucleus and targets the pre-mRNA processing factor 8 (Prp8) to block pre-mRNA splicing and mRNA synthesis [49]."
38457376
reach
"Picornavirus genome synthesis occurs in the cytoplasm, whereas 3D has a nuclear localization signal that enters the nucleus and targets the pre-mRNA processing factor 8 (Prp8) to block host pre-mRNA splicing and mRNA synthesis [39]."
38622757
PRPF8 affects ZNF830
3 |
PRPF8 binds ZNF830. 3 / 3
3 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
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No evidence text available
22365833
PRPF8 affects XAB2
2 | 1
PRPF8 binds XAB2. 3 / 3
2 | 1
reach
"First, we examined whether PRPF8 and XAB2 form a complex in the human osteosarcoma U2OS cell line, by performing co-IP analysis."
29212152
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
PRPF8 affects U2AF2
2 | 1
U2AF2 binds PRPF8. 3 / 3
2 | 1
reach
"BEDtools also cannot show regions of unfavorable binding (the correlation is always positive) or differentiate between upstream and downstream binding geometries.The resolution limit of BEDtools is apparent when observing the binding of PRPF8, RBM22, U2AF2, and BUD13: PRPF8 and RBM22 appear to bind close to each other and U2AF2 and BUD13 bind close to each other as expected (Figures S8H and S8I); however, there is minimal difference in the correlation of U2AF2 with BUD13 versus U2AF2 with PRPF8 or RBM22 (Figure S8I), even though PRPF8 and RBM22 are known to generally bind further from U2AF2 than BUD13."
35474897
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No evidence text available
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No evidence text available
26641092
PRPF8 affects TTC27
3 |
TTC27 binds PRPF8. 3 / 3
3 |
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No evidence text available
33961781
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No evidence text available
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No evidence text available
28515276
PRPF8 affects TCERG1
3 |
PRPF8 binds TCERG1. 3 / 3
3 |
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No evidence text available
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No evidence text available
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No evidence text available
37071682
PRPF8 affects STIP1
3 |
PRPF8 binds STIP1. 3 / 3
3 |
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No evidence text available
34079125
biogrid
No evidence text available
33239621
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No evidence text available
28515276
PRPF8 affects STAU1
3 |
STAU1 binds PRPF8. 3 / 3
3 |
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No evidence text available
36232890
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No evidence text available
30948266
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No evidence text available
23125841
PRPF8 affects SNRPN
3 |
SNRPN binds PRPF8. 3 / 3
3 |
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No evidence text available
28515276
biogrid
No evidence text available
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No evidence text available
28514442
PRPF8 affects SNRPG
3 |
SNRPG binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
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No evidence text available
28514442
PRPF8 affects SNRPA1
3 |
PRPF8 binds SNRPA1. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
PRPF8 affects SNRNP70
3 |
PRPF8 binds SNRNP70. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
biogrid
No evidence text available
29802200
PRPF8 affects SMU1
3 |
PRPF8 binds SMU1. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
27173435
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No evidence text available
28515276
PRPF8 affects SF3B6
3 |
SF3B6 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
PRPF8 affects SF3A2
3 |
SF3A2 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
17332742
biogrid
No evidence text available
22939629
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No evidence text available
35271311
PRPF8 affects RNA splicing
| 3
PRPF8 activates RNA splicing. 3 / 3
| 3
reach
"Further examples include human LINE-1 and other eukaryotic non-LTR retrotransposon RTs, which evolved variations of their reverse transcription and DNA integration mechanisms adapted to eukaryotic genomes and nuclear-cytoplasmic compartmentalization, and the core spliceosomal protein PRP8, which evolved from a group II intron-like RT and promotes RNA splicing by binding small nuclear RNAs derived from group II intron RNA domains (72)."
38608016
reach
"Other striking examples are the evolution of mobile group II introns or their close relatives into the eukaryotic RNA splicing apparatus, including the core spliceosomal protein PrP8, which evolved from a group II intron-like RT and promotes RNA splicing by interacting with snRNAs, which evolved from group II intron RNA domains, as well as closely related RTs encoded by LINE and other eukaryotic non-LTR retrotransposons, which use variations of the reverse transcription and DNA integration mechanisms adapted to eukaryotic genomes and nuclear-cytoplasmic compartmention."
37693417
reach
"Alterations of PRPF8 increase the proliferation of CD34+ primary bone marrow cells and of a myeloid cell line, as well as resulting in defects of the second step of the RNA splicing process [58]."
35885562
PRPF8 affects RBM39
2 | 1
RBM39 binds PRPF8. 3 / 3
2 | 1
reach
"In addition, physical interactions between RBM39 and SF3A1/2/3, SF3B4, PRPF8 and MBNL1 have also been reported (Figure 5A) (10,83)."
36477312
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No evidence text available
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35271311
PRPF8 affects PTK2
| 3
PRPF8 activates PTK2. 3 / 3
| 3
reach
"PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing."
36609600
reach
"PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating the FAK/AKT pathway via fibronectin 1 splicing [5]."
40136404
reach
"PRPF8 changes FN1 splicing and stimulates FAK/Akt axis in increasing HCC progression [85]."
38997297
PRPF8 affects PPIH
3 |
PRPF8 binds PPIH. 3 / 3
3 |
biogrid
No evidence text available
28515276
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No evidence text available
35271311
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No evidence text available
35831314
PRPF8 affects PLRG1
3 |
PRPF8 binds PLRG1. 3 / 3
3 |
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No evidence text available
34079125
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No evidence text available
28515276
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No evidence text available
26344197
PRPF8 affects PIH1D1
3 |
PRPF8 binds PIH1D1. 3 / 3
3 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28515276
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No evidence text available
34079125
PRPF8 affects N
3 |
N binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
34901782
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No evidence text available
39506849
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No evidence text available
33080218
PRPF8 affects ISY1
3 |
PRPF8 binds ISY1. 3 / 3
3 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
26344197
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No evidence text available
28515276
PRPF8 affects Hypoxia
| 3
PRPF8 activates Hypoxia. 3 / 3
| 3
reach
"CCK8 results revealed that transfection with PRP8 siRNA reversed hypoxia‐induced HPASMC proliferation, and this effect was eliminated after silencing circNAP1L4 (Figure 6E)."
39102213
reach
"Importantly, our results also showed that PRP8 siRNA reversed hypoxia‐induced HPASMC glycolysis and proliferation, suggesting that PH might be due in part to the aberrant NAP1L4 pre‐mRNA splicing caused by PRP8 in PASMCs."
39102213
reach
"These data suggest that PRPF8 supports hypoxia-induced mitochondrial clearance by ensuring correct ULK1 splicing, also with a likely effect on general autophagy, suggested by a global effect on autoph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32828649
PRPF8 affects HSF1
3 |
PRPF8 binds HSF1. 3 / 3
3 |
biogrid
No evidence text available
35906200
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No evidence text available
28515276
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No evidence text available
36339263
PRPF8 affects HNRNPU
3 |
HNRNPU binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
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No evidence text available
28515276
PRPF8 affects GPKOW
3 |
PRPF8 binds GPKOW. 3 / 3
3 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
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No evidence text available
22365833
PRPF8 affects Flag
| 3
PRPF8 binds Flag. 3 / 3
| 3
sparser
"Immunostaining of Drosophila S2 cells ( xref E–P) and imaginal discs ( xref Q,R,) further revealed that the transgenic wild-type Prp8 (Prp8 wt ) as well as the RP-Prp8 mutant variants primarily localized to the cytoplasm where the endogenous Drosophila Prp8 or transgenic human Flag::PRPF8 proteins were also mostly confined."
32424050
sparser
"Interestingly, when RUVBL1–RUVBL2, AAR2, ECD, RPAP3-PIH1D1 and ZNHIT2ΔC were added to the Flag-affinity resin loaded with Flag-PRPF8, all these proteins eluted with PRPF8 (Figure xref , xref )."
34951455
sparser
"However, when Flag-PRPF8 was present in the lysates, RUVBL1–RUVBL2 formed a direct complex with PRPF8, and this interaction was still detected when ATP was added to the reaction (Figure xref )."
34951455
PRPF8 affects FlaG
| 3
FlaG binds PRPF8. 3 / 3
| 3
sparser
"We therefore co-transfected constant amounts of plasmids encoding EFTUD2-FLAG, PRPF8-FLAG, and SNRNP200-FLAG, alongside increasing amounts of the plasmid encoding GFP-μ2."
36614170
sparser
"Even when the lowest amount of GFP-μ2 is expressed, the expression of both PRPF8-FLAG and SNRNP200-FLAG is nearly completely suppressed compared to the GFP control ( xref )."
36614170
sparser
"Moreover, we also tested a PRPF6-FLAG construct, which expression was suppressed by the presence of μ2 in the same fashion as PRPF8-FLAG and SNRNP200-FLAG."
36614170
PRPF8 affects ERG
3 |
ERG binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
21575865
biogrid
No evidence text available
24591637
biogrid
No evidence text available
24591637
PRPF8 affects EIF4G1
| 3
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
Docking protein-1 binds PRPF8 and EIF4G1. 1 / 1
| 1
sparser
"As a polymeric protein, pp62 protein is co-assembled with another polymeric protein, pp220, to form the inner core shell of ASFV ( xref )."
35097046
PRPF8 affects DNAAF10
3 |
DNAAF10 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
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No evidence text available
34079125
PRPF8 affects CDC40
2 | 1
PRPF8 binds CDC40.
2 |
PRPF8 binds CDC40. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
26344197
PRPF8 activates CDC40.
| 1
PRPF8 activates CDC40. 1 / 1
| 1
reach
"The other subdomain binds the RNaseH-like domain of Prp8 and is in close proximity of the Jab1/MPN domain of Prp8 ( Figures 3 B and 3C), which forms a stable complex with Brr2 throughout the two steps[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28502770
PRPF8 affects BSG
3 |
BSG binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
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No evidence text available
28514442
PRPF8 affects AQR
2 | 1
PRPF8 binds AQR. 3 / 3
2 | 1
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
sparser
"Focusing on SE events, for instance, we observed that AQR and PRPF8 binding at the flanking intronic regions of event body (location features γ and ζ ) associated with differential SE significantly (at FDR level of 0.05, Fig.  xref b and Additional file  xref : Figs."
| PMC
PRPF8 affects AKT
| 3
PRPF8 activates AKT. 3 / 3
| 3
reach
"PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing."
36609600
reach
"PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating the FAK/AKT pathway via fibronectin 1 splicing [5]."
40136404
reach
"PRPF8 changes FN1 splicing and stimulates FAK/Akt axis in increasing HCC progression [85]."
38997297
PPIH affects PRPF8
3 |
PRPF8 binds PPIH. 3 / 3
3 |
biogrid
No evidence text available
28515276
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No evidence text available
35271311
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No evidence text available
35831314
PLRG1 affects PRPF8
3 |
PRPF8 binds PLRG1. 3 / 3
3 |
biogrid
No evidence text available
34079125
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No evidence text available
28515276
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No evidence text available
26344197
PIH1D1 affects PRPF8
3 |
PRPF8 binds PIH1D1. 3 / 3
3 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28515276
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No evidence text available
34079125
N affects PRPF8
3 |
N binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
34901782
biogrid
No evidence text available
39506849
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No evidence text available
33080218
ISY1 affects PRPF8
3 |
PRPF8 binds ISY1. 3 / 3
3 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
HSP90 affects PRPF8
| 3
HSP90 binds PRPF8.
| 2
HSP90 binds PRPF8. 2 / 2
| 2
reach
"In this study, we show that the U5 specific proteins PRPF8 and EFTUD2 interact in vivo with HSP90 and R2TP and that these interactions arise early in the cytoplasm."
28515276
reach
"The HSP90 and R2TP machinery binds unassembled cytoplasmic forms of PRPF8 and EFTUD2."
28515276
HSP90 increases the amount of PRPF8.
| 1
HSP90 increases the amount of PRPF8. 1 / 1
| 1
reach
"First, inhibiting HSP90 leads to decreased levels of PRPF8 and SNRNP200."
28515276
HSF1 affects PRPF8
3 |
PRPF8 binds HSF1. 3 / 3
3 |
biogrid
No evidence text available
35906200
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No evidence text available
28515276
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No evidence text available
36339263
HNRNPU affects PRPF8
3 |
HNRNPU binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
22939629
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No evidence text available
35831314
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No evidence text available
28515276
GPKOW affects PRPF8
3 |
PRPF8 binds GPKOW. 3 / 3
3 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
Flag affects PRPF8
| 3
PRPF8 binds Flag. 3 / 3
| 3
sparser
"Immunostaining of Drosophila S2 cells ( xref E–P) and imaginal discs ( xref Q,R,) further revealed that the transgenic wild-type Prp8 (Prp8 wt ) as well as the RP-Prp8 mutant variants primarily localized to the cytoplasm where the endogenous Drosophila Prp8 or transgenic human Flag::PRPF8 proteins were also mostly confined."
32424050
sparser
"Interestingly, when RUVBL1–RUVBL2, AAR2, ECD, RPAP3-PIH1D1 and ZNHIT2ΔC were added to the Flag-affinity resin loaded with Flag-PRPF8, all these proteins eluted with PRPF8 (Figure xref , xref )."
34951455
sparser
"However, when Flag-PRPF8 was present in the lysates, RUVBL1–RUVBL2 formed a direct complex with PRPF8, and this interaction was still detected when ATP was added to the reaction (Figure xref )."
34951455
FlaG affects PRPF8
| 3
FlaG binds PRPF8. 3 / 3
| 3
sparser
"We therefore co-transfected constant amounts of plasmids encoding EFTUD2-FLAG, PRPF8-FLAG, and SNRNP200-FLAG, alongside increasing amounts of the plasmid encoding GFP-μ2."
36614170
sparser
"Even when the lowest amount of GFP-μ2 is expressed, the expression of both PRPF8-FLAG and SNRNP200-FLAG is nearly completely suppressed compared to the GFP control ( xref )."
36614170
sparser
"Moreover, we also tested a PRPF6-FLAG construct, which expression was suppressed by the presence of μ2 in the same fashion as PRPF8-FLAG and SNRNP200-FLAG."
36614170
ERG affects PRPF8
3 |
ERG binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
21575865
biogrid
No evidence text available
24591637
biogrid
No evidence text available
24591637
EIF4G1 affects PRPF8
| 3
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
Docking protein-1 binds PRPF8 and EIF4G1. 1 / 1
| 1
sparser
"As a polymeric protein, pp62 protein is co-assembled with another polymeric protein, pp220, to form the inner core shell of ASFV ( xref )."
35097046
DNAAF10 affects PRPF8
3 |
DNAAF10 binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
28561026
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
CDK2 affects PRPF8
| 3
CDK2 phosphorylates PRPF8. 3 / 3
| 3
sparser
"In somatic cells, histone H4 gene expression is controlled by CDK2 phosphorylation of p220(NPAT) and localization of HiNF-P/p220(NPAT) complexes with histone genes at Cajal body related subnuclear foci."
17520687
sparser
"Although appearance of CDK2-phosphorylated p220(NPAT) in these domains occurs at the time of S-phase entry, histone locus bodies are formed approximately 1 to 2 h before S phase in embryonic cells but 6 h before S phase in somatic cells."
18957539
sparser
"Basal histone H4 expression in G0/G1, although p220 dependent, occurs in the absence of detectable phosphorylation of p220 on Cdk2 sites."
14612403
BSG affects PRPF8
3 |
BSG binds PRPF8. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
AQR affects PRPF8
2 | 1
PRPF8 binds AQR. 3 / 3
2 | 1
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
sparser
"Focusing on SE events, for instance, we observed that AQR and PRPF8 binding at the flanking intronic regions of event body (location features γ and ζ ) associated with differential SE significantly (at FDR level of 0.05, Fig.  xref b and Additional file  xref : Figs."
| PMC
17alpha-ethynylestradiol increases the amount of PRPF8. 3 / 3
3 |
ctd
No evidence text available
17108234
ctd
No evidence text available
24096037
ctd
No evidence text available
17942748
Copper(2+) affects PRPF8
| 2
Copper(2+) inhibits PRPF8. 2 / 2
| 2
reach
"Biologically relevant metal ions Cu 2+ and Zn 2+ at 0.5 mM and 2 mM respectively could inhibit splicing of the C. neoformans Prp8 intein in an in vitro Prp8 intein splicing assay, whereas Mg 2+ at 0.5 mM and 2 mM did not ."
35211511
reach
"Like other stressors known to inhibit RNA splicing, copper and zinc would act post-translationally to block Prp8 intein splicing and inhibit spliceosome function until levels of the metals are diminished by scavenger proteins or metal transporters [73]."
31600193
Cadmium dichloride increases the amount of PRPF8. 2 / 2
2 |
ctd
No evidence text available
38382870
ctd
No evidence text available
19187980
Bisphenol F affects PRPF8
2 |
Bisphenol F decreases the amount of PRPF8. 2 / 2
2 |
ctd
No evidence text available
28628672
ctd
No evidence text available
36041667
ZGPAT affects PRPF8
2 |
ZGPAT binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28878014
biogrid
No evidence text available
28515276
ZC3H18 affects PRPF8
2 |
PRPF8 binds ZC3H18. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
29298432
YBX1 affects PRPF8
2 |
PRPF8 binds YBX1. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
VIRMA affects PRPF8
2 |
VIRMA binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
29507755
biogrid
No evidence text available
29507755
USP9X affects PRPF8
2 |
USP9X binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
35831314
URI1 affects PRPF8
2 |
URI1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
UBR5 affects PRPF8
2 |
UBR5 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
31365120
biogrid
No evidence text available
35831314
U6 RNA affects PRPF8
| 2
PRPF8 binds U6 RNA. 2 / 2
| 2
reach
"In yeast, CWC15 stabilizes the interaction between U6 RNA and PRP8 ."
38493158
reach
"Prpf3 is part of U4/U6-U 5 tri-snRNP, whereas Prpf31 binds to the U4 snRNP and Prpc8 interacts with U6 RNA."
21283520
U2SURP affects PRPF8
1 | 1
U2SURP binds PRPF8. 2 / 2
1 | 1
biogrid
No evidence text available
35831314
reach
"Interactions between PRPF8, U2SURP, or DDX5 with SMG1 did not change in the presence or absence of radiation (Fig. 3D and E and Supplementary fig."
36921295
TUBB affects PRPF8
2 |
PRPF8 binds TUBB. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
TUBA4A affects PRPF8
2 |
TUBA4A binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
TOP1 affects PRPF8
2 |
TOP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
15848144
TMED9 affects PRPF8
| 2
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
Snw1 affects PRPF8
2 |
Snw1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
20360068
biogrid
No evidence text available
26496610
STUB1 affects PRPF8
2 |
PRPF8 binds STUB1. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
SSs affects PRPF8
| 2
SSs binds PRPF8. 2 / 2
| 2
reach
"RP13-ROs had significantly fewer weak 5’SSs bound to PRPF8 in transcripts encoding proteins mediating transcription, and ciliary functions (Fig. 7B, C), corroborating the enrichment of ciliary transcripts that undergo alternative exon usage in this tissue (Fig. 3F)."
38605034
reach
"RP13-RPE had slightly more weak 5’SSs bound to PRPF8 (Fig. 7B and Supplementary data 8) affecting similar pathways (Fig. 7D; RNA binding, nucleolus, nuclear lumen; cilium assembly, cilium)."
38605034
SSRP1 affects PRPF8
2 |
SSRP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
35831314
SRRM1 affects PRPF8
2 |
SRRM1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
10809668
biogrid
No evidence text available
16159877
SRPK2 affects PRPF8
2 |
SRPK2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
32707033
biogrid
No evidence text available
26344197
SRPK1 affects PRPF8
2 |
SRPK1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
15034300
SLC7A6OS affects PRPF8
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
SERBP1 affects PRPF8
2 |
PRPF8 binds SERBP1. 2 / 2
2 |
biogrid
No evidence text available
37223481
biogrid
No evidence text available
28515276
SCARB2 affects PRPF8
2 |
SCARB2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
30833792
reach
"Retinitis pigmentosa-linked mutations impair the snRNA unwinding activity of SNRNP200 and reduce pre-mRNA binding of PRPF8."
40045025
reach
"Variants in PRPF8 cause retinitis pigmentosa type 13 (RP-13)."
40264708
RPS25 affects PRPF8
2 |
PRPF8 binds RPS25. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
RPS14 affects PRPF8
2 |
PRPF8 binds RPS14. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
RPLP0 affects PRPF8
2 |
RPLP0 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
RPL6 affects PRPF8
2 |
PRPF8 binds RPL6. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
RPL11 affects PRPF8
2 |
PRPF8 binds RPL11. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
RPA3 affects PRPF8
2 |
RPA3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
37827155
biogrid
No evidence text available
24332808
RPA2 affects PRPF8
2 |
RPA2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
24332808
biogrid
No evidence text available
37827155
RPA1 affects PRPF8
2 |
RPA1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
37827155
biogrid
No evidence text available
24332808
RNPS1 affects PRPF8
2 |
RNPS1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
17353931
RIOK1 affects PRPF8
2 |
PRPF8 binds RIOK1. 2 / 2
2 |
biogrid
No evidence text available
27173435
biogrid
No evidence text available
21081503
Particulate Matter increases the amount of PRPF8. 2 / 2
2 |
ctd
No evidence text available
35964746
ctd
No evidence text available
36877189
PTGES3 affects PRPF8
2 |
PRPF8 binds PTGES3. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
28515276
PRPF8 affects Δ
| 2
PRPF8 inhibits Δ. 2 / 2
| 2
reach
"Identification of mutants in Prp8 that suppress fyv6Δ is not surprising since many different alleles of Prp8 are known to modulate the conformational equilibrium between the 1 and 2 steps (Fica and Nagai, 2017; L. Liu et al., 2007; Query and Konarska, 2004) or other steps in splicing."
38746449
reach
"Identification of mutants in Prp8 that suppress fyv6Δ is not surprising since many different alleles of Prp8 are known to modulate the conformational equilibrium between the first and second steps (Fica and Nagai, 2017; Liu et al., 2007b; Query and Konarska, 2004) or other steps in splicing."
39688371
PRPF8 affects prp16-302 allele
| 2
PRPF8 inhibits prp16-302 allele. 2 / 2
| 2
reach
"Furthermore, whereas second-step alleles improve the second step, the N-terminal alleles inhibit both catalytic steps, indicating that they act by different mechanisms.Alleles in three spliceosomal factors: U6, Cwc2, and Prp8, that suppress defects of the prp16-302 allele, identified important catalytic interactions stabilizing the first-step conformation but destabilized by the Prp16 ATPase at the transition to the second step."
38876504
reach
"These prp8 alleles significantly suppress growth defects of prp16-302 allele (Fig. 4B), and most of them (prp8-F331L, Y356C, Y590C/F, K603I, K611I/T, and S613T) also correct growth defects of prp16-R686I, demonstrating the generality of these effects (Fig. 4C)."
38876504
PRPF8 affects proliferative migratory invasive cells
| 2
PRPF8 activates proliferative migratory invasive cells. 2 / 2
| 2
eidos
"Taken together , Prp8 knockdown reduced the proliferative , migratory and invasive abilities of HCC cells ."
32547101
eidos
"Collectively , Prp8 promoted the proliferative , migratory and invasive abilities of HCC cells ."
32547101
PRPF8 affects migration
| 2
PRPF8 activates migration. 2 / 2
| 2
eidos
"Upregulation of Prp8 promoted cell viability and migration in a human hepatic astrocyte line ."
32547101
eidos
"Upregulation of Prp8 promoted cell viability and migration in HCC cells ."
32547101
PRPF8 affects immune response
| 1 1
PRPF8 activates immune response. 2 / 2
| 1 1
eidos
"Furthermore , PRPF8 , AKAP9 , UVRAG , HDAC10 and NFE2L1 are known to mediate the immune response ."
33468065
reach
"Furthermore, PRPF8, AKAP9, UVRAG, HDAC10 and NFE2L1 are known to mediate the immune response."
33468065
PRPF8 activates glycolytic process. 2 / 2
| 2
reach
"Moreover, HPASMC glycolysis was abrogated by PRP8 siRNA under hypoxia, and circNAP1L4 siRNA enhanced this effect (Figure 6I)."
39102213
reach
"Taken together, these findings suggest that PRP8 leads to abnormal activation of HPASMC proliferation and glycolysis under hypoxia, which is achieved mainly through circNAP1L4.3.9 CircNAP1L4 alleviates SuHx-induced PH in mice."
39102213
reach
"PRP8 Induces the Biogenesis of CircMaml2."
36359856
reach
"Furthermore, PRP8 was discovered to promote the biogenesis of circMaml2."
36359856
PRPF8 affects ZGPAT
2 |
ZGPAT binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28878014
biogrid
No evidence text available
28515276
PRPF8 affects ZC3H18
2 |
PRPF8 binds ZC3H18. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
29298432
PRPF8 affects YBX1
2 |
PRPF8 binds YBX1. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
PRPF8 affects VIRMA
2 |
VIRMA binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
29507755
biogrid
No evidence text available
29507755
PRPF8 affects USP9X
2 |
USP9X binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
35831314
PRPF8 affects URI1
2 |
URI1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
PRPF8 affects UBR5
2 |
UBR5 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
31365120
biogrid
No evidence text available
35831314
PRPF8 affects U6 RNA
| 2
PRPF8 binds U6 RNA. 2 / 2
| 2
reach
"In yeast, CWC15 stabilizes the interaction between U6 RNA and PRP8 ."
38493158
reach
"Prpf3 is part of U4/U6-U 5 tri-snRNP, whereas Prpf31 binds to the U4 snRNP and Prpc8 interacts with U6 RNA."
21283520
PRPF8 affects U4/U6
| 2
PRPF8 activates U4/U6. 2 / 2
| 2
reach
"Following de-ubiquitination of Prp8, Brr2 is free to promote unwinding of U4/U6, resulting in activation of the spliceosome [48]."
| PMC
reach
"Indeed a C-terminal fragment of Prp8 — encompassing the RNaseH-like and Jab/MPN1-like domains — strongly stimulates Brr2-dependent U4/U6 unwinding in vitro [ 44 ]."
20089394
PRPF8 affects U2SURP
1 | 1
U2SURP binds PRPF8. 2 / 2
1 | 1
biogrid
No evidence text available
35831314
reach
"Interactions between PRPF8, U2SURP, or DDX5 with SMG1 did not change in the presence or absence of radiation (Fig. 3D and E and Supplementary fig."
36921295
PRPF8 affects TUBB
2 |
PRPF8 binds TUBB. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
PRPF8 affects TUBA4A
2 |
TUBA4A binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
PRPF8 affects TOP1
2 |
TOP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
15848144
PRPF8 affects TMED9
| 2
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
PRPF8 affects Snw1
2 |
Snw1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
20360068
biogrid
No evidence text available
26496610
PRPF8 affects STUB1
2 |
PRPF8 binds STUB1. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
PRPF8 affects SSs
| 2
SSs binds PRPF8. 2 / 2
| 2
reach
"RP13-ROs had significantly fewer weak 5’SSs bound to PRPF8 in transcripts encoding proteins mediating transcription, and ciliary functions (Fig. 7B, C), corroborating the enrichment of ciliary transcripts that undergo alternative exon usage in this tissue (Fig. 3F)."
38605034
reach
"RP13-RPE had slightly more weak 5’SSs bound to PRPF8 (Fig. 7B and Supplementary data 8) affecting similar pathways (Fig. 7D; RNA binding, nucleolus, nuclear lumen; cilium assembly, cilium)."
38605034
PRPF8 affects SSRP1
2 |
SSRP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
35831314
PRPF8 affects SRRM1
2 |
SRRM1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
10809668
biogrid
No evidence text available
16159877
PRPF8 affects SRPK2
2 |
SRPK2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
32707033
biogrid
No evidence text available
26344197
PRPF8 affects SRPK1
2 |
SRPK1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
15034300
PRPF8 affects SLC7A6OS
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
28561026
PRPF8 affects SERBP1
2 |
PRPF8 binds SERBP1. 2 / 2
2 |
biogrid
No evidence text available
37223481
biogrid
No evidence text available
28515276
PRPF8 affects SCARB2
2 |
SCARB2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
30833792
PRPF8 activates Retinitis Pigmentosa. 2 / 2
| 2
reach
"The authors differentiated gene-corrected patient urinary iPSCs to RPE cells and generated 3D ROs rescuing photoreceptor structure and electrophysiological properties, reversing the observed ciliopathy and restoring gene expression to a level in accordance with that in the control using transcriptome-based analysis.A study by Foltz and colleagues [100] describes the use of genome editing technology in patient-derived iPSCs to correct the c.6901C>T point mutation in the PRPF8 gene that causes Retinitis Pigmentosa 13 (RP13), thus generating an isogenic control line for cellular modelling."
36499601
reach
"A better knowledge of how Prp8 suppresses the effect of mutations at well-conserved 5′-GU and 3′-branch-point sites under the control of various DExD/H-box proteins could open a novel way to correct t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16009556
PRPF8 affects RPS3
1 | 1
PRPF8 inhibits RPS3.
| 1
Mutated PRPF8 inhibits RPS3. 1 / 1
| 1
reach
"These RPE abnormalities are more severe in the homozygous Prpf3-T494M and Prpf8-H2309P mice, suggesting that RP18 and RP13 are caused by the gain-of-function or dominant negative effect of Prpf3 and Prpf8 mutations."
34395430
PRPF8 binds RPS3.
1 |
PRPF8 binds RPS3. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPS25
2 |
PRPF8 binds RPS25. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
PRPF8 affects RPS14
2 |
PRPF8 binds RPS14. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
PRPF8 affects RPLP0
2 |
RPLP0 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
PRPF8 affects RPL6
2 |
PRPF8 binds RPL6. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
PRPF8 affects RPL11
2 |
PRPF8 binds RPL11. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
PRPF8 affects RPA3
2 |
RPA3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
37827155
biogrid
No evidence text available
24332808
PRPF8 affects RPA2
2 |
RPA2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
24332808
biogrid
No evidence text available
37827155
PRPF8 affects RPA1
2 |
RPA1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
37827155
biogrid
No evidence text available
24332808
PRPF8 affects RNPS1
2 |
RNPS1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
17353931
PRPF8 affects RIOK1
2 |
PRPF8 binds RIOK1. 2 / 2
2 |
biogrid
No evidence text available
27173435
biogrid
No evidence text available
21081503
PRPF8 affects PTGES3
2 |
PRPF8 binds PTGES3. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
28515276
PRPF8 affects PRKN
2 |
PRKN binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35509820
biogrid
No evidence text available
35256949
PRPF8 affects PRKDC
2 |
PRKDC binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
PRPF8 affects PPWD1
1 | 1
PRPF8 binds PPWD1. 2 / 2
1 | 1
biogrid
No evidence text available
28515276
sparser
"We find PPWD1 interacting with PRPF8 through both its PPI and WD40-domains, which also interacts with U5 snRNP 200 kDa ( xref )."
30518120
PRPF8 affects PPP1CA
2 |
PRPF8 binds PPP1CA. 2 / 2
2 |
biogrid
No evidence text available
29669786
biogrid
No evidence text available
28515276
PRPF8 affects PPIL1
2 |
PRPF8 binds PPIL1. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
PRPF8 affects PPIE
2 |
PPIE binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
27684187
biogrid
No evidence text available
28515276
PRPF8 affects PHB1
2 |
PRPF8 binds PHB1. 2 / 2
2 |
biogrid
No evidence text available
27025967
biogrid
No evidence text available
28515276
PRPF8 affects PABPC1
2 |
PABPC1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
PRPF8 affects ORF9c
2 |
ORF9c binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35180394
biogrid
No evidence text available
| DOI
PRPF8 affects Neoplasms
| 2
PRPF8 activates Neoplasms. 2 / 2
| 2
reach
"Therefore, further investigation into the widely applicable downstream targets activated by PRPF8 across different tumors or at various stages of tumor progression may enhance the understanding of cancer development mechanisms and offer promising implications for cancer therapy."
40136404
reach
"PRPF8 silencing ameliorated aggressiveness in vitro and decreased tumor growth in vivo."
36609600
PRPF8 activates Neoplasm Metastasis. 2 / 2
| 2
eidos
"Functionally , the loss of Prp8 may specifically inhibit cell viability and metastasis and activated EMT and PI3K / Akt in HCC cells ."
32547101
eidos
"The upregulation of Prp8 promoted cell viability , metastasis and the activity of the PI3K / Akt pathway in hepatic astrocytes cells and HCC cells ."
32547101
PRPF8 affects NUDCD2
2 |
PRPF8 binds NUDCD2. 2 / 2
2 |
biogrid
No evidence text available
32665550
biogrid
No evidence text available
34079125
PRPF8 affects NPM1
2 |
PRPF8 binds NPM1. 2 / 2
2 |
biogrid
No evidence text available
39501047
biogrid
No evidence text available
28515276
PRPF8 affects NCL
2 |
NCL binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
27049334
biogrid
No evidence text available
28515276
PRPF8 affects NCDN
2 |
PRPF8 binds NCDN. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
PRPF8 affects MFAP1
2 |
MFAP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
40437099
biogrid
No evidence text available
37071682
PRPF8 affects METTL14
2 |
METTL14 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
29507755
biogrid
No evidence text available
36597993
PRPF8 affects MATR3
2 |
MATR3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
29511296
PRPF8 affects LUC7L2
2 |
PRPF8 binds LUC7L2. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
PRPF8 affects LSM2
2 |
PRPF8 binds LSM2. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
29395067
PRPF8 affects LRRC59
2 |
PRPF8 binds LRRC59. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
32788342
PRPF8 affects LCN2
| 2
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
PRPF8 affects KPNB1
2 |
PRPF8 binds KPNB1. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
PRPF8 affects KPNA4
2 |
PRPF8 binds KPNA4. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
26344197
PRPF8 affects KIAA1143
2 |
KIAA1143 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
PRPF8 affects ISPH
| 2
PRPF8 inhibits ISPH. 2 / 2
| 2
reach
"Using two independent siRNAs targeting PRPF8 (siPRPF8-2, siPRPF8-4), as well as a previously described siRNA targeting XAB2 (siXAB2-4), we found that PRPF8 and XAB2 depletion cause a significantly greater decrease in the frequency of HDR and SSA, compared to EJ."
29212152
reach
"Depletion of PRPF8 and treatment with a small molecule spliceosome inhibitor (PlaB) disrupts HDR, SSA, and end resection."
29212152
PRPF8 affects IPO7
2 |
PRPF8 binds IPO7. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
PRPF8 affects IK
2 |
PRPF8 binds IK. 2 / 2
2 |
biogrid
No evidence text available
39358380
biogrid
No evidence text available
28515276
PRPF8 affects Histone_H4
| 2
PRPF8 activates Histone_H4. 2 / 2
| 2
sparser
"In cells where HiNF-P and p220(NPAT) do not activate the H4 gene promoter, HiNF-P instead represses transcription."
17163457
sparser
"Here we find that γ-irradiation induces p21 CIP1/WAF1 but not the other two CKIs, while reducing histone H4 mRNA levels but not histone H4 gene promoter activation by the p220 NPAT /HiNF-P complex."
19170105
PRPF8 affects Histone
| 2
PRPF8 activates Histone. 2 / 2
| 2
sparser
"Irradiation reduces histone mRNA levels but not histone gene promoter activation by the p220 NPAT /HiNF-P complex."
19170105
sparser
"Hence, physiological induction of p21 CIP1/WAF1 during a genotoxic stress response contributes to a reduction of histone mRNA accumulation but does not impinge on the CDK2 dependent transcriptional activation of histone genes by the p220 NPAT /HiNF-P complex."
19170105
PRPF8 affects HUWE1
2 |
HUWE1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
PRPF8 affects HSPA8
2 |
HSPA8 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
27684187
biogrid
No evidence text available
28515276
PRPF8 affects HSPA5
2 |
PRPF8 binds HSPA5. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
PRPF8 affects HSPA1A
2 |
PRPF8 binds HSPA1A. 2 / 2
2 |
biogrid
No evidence text available
32687490
biogrid
No evidence text available
28515276
PRPF8 affects HSP90AA1
2 |
HSP90AA1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
19875381
biogrid
No evidence text available
28515276
PRPF8 affects HSP90
| 2
HSP90 binds PRPF8. 2 / 2
| 2
reach
"In this study, we show that the U5 specific proteins PRPF8 and EFTUD2 interact in vivo with HSP90 and R2TP and that these interactions arise early in the cytoplasm."
28515276
reach
"The HSP90 and R2TP machinery binds unassembled cytoplasmic forms of PRPF8 and EFTUD2."
28515276
PRPF8 affects HRES1
| 2
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
PRPF8 affects HNRNPM
2 |
HNRNPM binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
PRPF8 affects HNRNPK
1 | 1
PRPF8 binds HNRNPK. 2 / 2
1 | 1
sparser
"These results suggested that C'2 and D are probably the functional domains, which affect the binding of snoRD126 to hnRNPK and PRPF8 proteins."
33891563
biogrid
No evidence text available
28515276
PRPF8 affects HNRNPH2
2 |
PRPF8 binds HNRNPH2. 2 / 2
2 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
PRPF8 affects HNRNPC
2 |
PRPF8 binds HNRNPC. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
PRPF8 affects HNRNPA1
2 |
HNRNPA1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
22446626
biogrid
No evidence text available
28515276
PRPF8 affects HMGB1
2 |
HMGB1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
29721183
biogrid
No evidence text available
35235311
PRPF8 affects HDLBP
2 |
PRPF8 binds HDLBP. 2 / 2
2 |
biogrid
No evidence text available
36244648
biogrid
No evidence text available
28515276
PRPF8 affects HADHA
2 |
PRPF8 binds HADHA. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
PRPF8 affects H4C16
2 |
PRPF8 binds H4C16. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
30804502
PRPF8 affects H2BC5
2 |
PRPF8 binds H2BC5. 2 / 2
2 |
biogrid
No evidence text available
31152661
biogrid
No evidence text available
31152661
PRPF8 affects H2BC21
2 |
H2BC21 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
30021884
biogrid
No evidence text available
35271311
PRPF8 affects G3BP2
2 |
PRPF8 binds G3BP2. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
34901782
PRPF8 affects FYV6
| 2
FYV6 binds PRPF8. 2 / 2
| 2
reach
"Genetic interactions between Fyv6 and Prp8 first or second-step alleles."
37625852
reach
"Genetic Interactions between Fyv6 and Prp8 1 st or 2 nd -Step Alleles."
36778415
PRPF8 affects FN1
| 2
PRPF8 activates FN1. 2 / 2
| 2
reach
"These results showed that PRPF8 silencing induced a reduction in the PSI value of FN1 exon 40.2 inclusion, while restoration of PRPF8 expression in silenced Hep3B cells by PRPF8 overexpression restored the PSI value of FN1 in parental cells (Fig. 5j)."
36609600
reach
"To further confirm the role of PRPF8 in cell invasion, we investigated whether PRPF8 silencing can block the secretion of proinvasive molecules, including FN1 splice variants."
36609600
PRPF8 affects FBXO22
2 |
PRPF8 binds FBXO22. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
36774506
PRPF8 affects EP300
2 |
EP300 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
33742100
biogrid
No evidence text available
30110629
PRPF8 affects EIF4A3
2 |
EIF4A3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
23084401
biogrid
No evidence text available
28515276
PRPF8 affects EEF1G
2 |
PRPF8 binds EEF1G. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
PRPF8 affects EEF1D
2 |
PRPF8 binds EEF1D. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
PRPF8 affects EBNA-LP
1 1 |
PRPF8 binds EBNA-LP. 2 / 2
1 1 |
biogrid
No evidence text available
18457437
virhostnet
No evidence text available
18457437
PRPF8 affects E6
1 | 1
PRPF8 decreases the amount of E6.
| 1
PRPF8 decreases the amount of E6. 1 / 1
| 1
reach
"Although KD of ECD and PRPF8 appeared to decrease the expression of intact E6 (intron-containing) RNA, there was no difference among the three groups (Fig. 4B; Supplementary Table S5)."
34670863
PRPF8 binds E6.
1 |
PRPF8 binds E6. 1 / 1
1 |
virhostnet
No evidence text available
22898364
PRPF8 affects Disease
| 2
Mutated PRPF8 activates Disease. 2 / 2
| 2
reach
"It is reported that PRPF8 mutation caused aberrant splicing in some human diseases, such as myeloid malignancies and autosomal-dominant retinitis pigmentosa (Kurtovic-Kozaric et al., 2015; Xiao et al., 2020)."
34434935
reach
"Additionally, the reasons why different PRPF8 mutations and/or varying expression levels contribute to distinct diseases, such as various cancers or retinal diseases, remain elusive."
40136404
PRPF8 affects DSG1
2 |
PRPF8 binds DSG1. 2 / 2
2 |
biogrid
No evidence text available
40437099
biogrid
No evidence text available
28515276
PRPF8 affects DNAJC17
2 |
PRPF8 binds DNAJC17. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
33957083
PRPF8 affects DHX8
1 | 1
PRPF8 binds DHX8. 2 / 2
1 | 1
biogrid
No evidence text available
28515276
sparser
"DHX8 also directly interacts with PRPF8 and plays a role in positioning the 3′ splice site for step II catalysis, and this is similar to what occurs after exon ligation, which is thought to bind and pull the 3′ sequences of the ligated exon, releasing the exon of the P complex ( xref ; xref ) ( xref )."
36609432
PRPF8 affects DHX38
2 |
PRPF8 binds DHX38. 2 / 2
2 |
biogrid
No evidence text available
37071682
biogrid
No evidence text available
28515276
PRPF8 affects DHX16
| 2
DHX16 binds PRPF8. 2 / 2
| 2
reach
"This flexible anchoring is conditioned by the hook of PRP2 binding to PRP8, the presence of which may serve as a signature for the occurrence of the translocation of PRP2."
37165190
reach
"Moreover, the clip of PRP2 replaced SNIP1 by interacting with the α3 helix of SKIP, whereas new interactions between PRP2 , SKIP and PRP8 replace those between BUD13 and SKIP in the B complex (Fig. 3a and Extended Data Fig. 4c,d)."
37165190
PRPF8 affects DDX5
1 | 1
PRPF8 binds DDX5. 2 / 2
1 | 1
biogrid
No evidence text available
28515276
reach
"Interactions between PRPF8, U2SURP, or DDX5 with SMG1 did not change in the presence or absence of radiation (Fig. 3D and E and Supplementary fig."
36921295
PRPF8 affects DDX3X
2 |
DDX3X binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
PRPF8 affects DDX21
2 |
DDX21 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
35831314
PRPF8 affects DDB1
2 |
PRPF8 binds DDB1. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
PRPF8 affects CircMaml2
| 2
PRPF8 activates CircMaml2. 2 / 2
| 2
reach
"PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62."
36359856
reach
"PRP8 Induces the Biogenesis of CircMaml2."
36359856
reach
"PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing."
36609600
reach
"PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating the FAK/AKT pathway via fibronectin 1 splicing [5]."
40136404
PRPF8 affects CWF19L1
2 |
PRPF8 binds CWF19L1. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
PRPF8 affects CUL3
2 |
CUL3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
21145461
biogrid
No evidence text available
35563538
PRPF8 affects COPS5
| 2
PRPF8 binds COPS5. 2 / 2
| 2
sparser
"In contrast, the C-terminal Jab1 domain of the large spliceosomal PRPF8 scaffold that can activate the SNRNP200 helicase directly binds the active NC xref , xref ."
37019967
sparser
"For crystallographic analyses, we used N-terminally truncated hBrr2 T1 in complex with the Jab1 domain of the hPrp8 protein lacking a Brr2-inhibiting C-terminal tail (hJab1 ΔC )."
34048711
PRPF8 affects CCNF
2 |
CCNF binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
33729478
biogrid
No evidence text available
36114006
PRPF8 affects Brr2p
| 2
Mutated PRPF8 inhibits Brr2p. 1 / 1
| 1
reach
"The fact that the U4-cs1 mutation, which blocks splicing at low temperature by hyperstabilizing the U4/U6 duplex [71] , becomes synthetically lethal in combination with either brr2 - 1 or prp28 - 1 mu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23454554
PRPF8 inhibits Brr2p. 1 / 1
| 1
reach
"For example, a previous study suggested that mutations in PRPF8 may cause RP by disrupting the nuclear association of Brr2p with the U5 snRNP and, consequently, the assembly of the triple snRNP."
19878916
PRPF8 affects BUD31
2 |
PRPF8 binds BUD31. 2 / 2
2 |
biogrid
No evidence text available
37071682
biogrid
No evidence text available
34079125
PRPF8 affects BLM
| 2
PRPF8 inhibits mutated BLM. 2 / 2
| 2
reach
"Two of these SS/BS suppressors represent alleles of PRP8 ( prp8 - 161 and prp8 - 162 ); furthermore, previously characterized splice site prp8 alleles also suppress BS mutations."
15125837
reach
"This confirms that BS suppressors 1 and 2 represent prp8 alleles and thus that some prp8 alleles can suppress BS mutations.These results suggested that the previously isolated splice site prp8 suppres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15125837
PRPF8 affects BAP1
2 |
BAP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
34591877
biogrid
No evidence text available
35446349
PRPF8 affects BAG5
2 |
PRPF8 binds BAG5. 2 / 2
2 |
biogrid
No evidence text available
32850835
biogrid
No evidence text available
28515276
PRPF8 affects BAG2
2 |
PRPF8 binds BAG2. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
PRPF8 inhibits ATP hydrolysis activity. 2 / 2
| 2
sparser
"Interestingly, in contrast to its stimulation of Brr2 helicase activity, the wild-type Prp8 fragment actually inhibited the RNA-dependent ATPase activity of Brr2."
19098916
sparser
"WT Brr2 also demonstrates RNA stimulated ATPase activity which is inhibited by Prp8-CTR ( xref )."
19525970
PRPF8 affects ANXA2
2 |
PRPF8 binds ANXA2. 2 / 2
2 |
biogrid
No evidence text available
30021884
biogrid
No evidence text available
28515276
PRPF8 affects ANLN
2 |
ANLN binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
31586073
biogrid
No evidence text available
36526897
PRPF8 affects AGR2
2 |
AGR2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
30575818
biogrid
No evidence text available
30575818
PRPF8 affects 3D
| 2
3D binds PRPF8. 2 / 2
| 2
reach
"For example, 3D polymerase from enterovirus 71 directly binds to pre-mRNA processing factor 8 (PRPF8) and disrupts the pre-mRNA splicing processes, contributing to the invasion of the virus (Liu et al., 2014)."
36891156
reach
"In the case of picornaviruses, it has been shown recently that the viral polymerase 3D binds to PRPF8, a core components of U5, and blocks mRNA maturation, with the consequent accumulation of the lariat intermediate [XREF_BIBR]."
27575636
PRP8 affects MT-ATP6
| 2
Bloc1s3 binds MT-ATP6, PRPF8, and PRP8. 2 / 2
| 2
sparser
"Thus the Prp8p-Aar2p complex that accumulates in the prp8-rp mutants is nuclear and therefore, unlike the situation with ΔNLS-Prp8p, has the possibility to interact with Brr2p but does so with reduced efficiency as a consequence of the poor association of Brr2p with Prp8-rp mutant proteins."
17934474
sparser
"Compared to wild-type Prp8p ( xref ), the Prp8-rp mutant proteins were associated with less Brr2p ( xref , lanes 1-7) and with more Aar2p ( xref , lanes 9-13)."
17934474
PRKN affects PRPF8
2 |
PRKN binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35509820
biogrid
No evidence text available
35256949
PRKDC affects PRPF8
2 |
PRKDC binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
PPWD1 affects PRPF8
1 | 1
PRPF8 binds PPWD1. 2 / 2
1 | 1
biogrid
No evidence text available
28515276
sparser
"We find PPWD1 interacting with PRPF8 through both its PPI and WD40-domains, which also interacts with U5 snRNP 200 kDa ( xref )."
30518120
PPP1CA affects PRPF8
2 |
PRPF8 binds PPP1CA. 2 / 2
2 |
biogrid
No evidence text available
29669786
biogrid
No evidence text available
28515276
PPIL1 affects PRPF8
2 |
PRPF8 binds PPIL1. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
PPIE affects PRPF8
2 |
PPIE binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
27684187
biogrid
No evidence text available
28515276
PKC affects PRPF8
| 2
PKC phosphorylates PRPF8. 2 / 2
| 2
sparser
"This distinguishes this kinase, tentatively ca/led 4E kinase, from protein kinase C which phosphorylates p220 at a more rapid rate than p25 of elF-4F (24)."
2967701
sparser
"This is an important point because protein kinase C phosphorylates both p220 and p25 of elF-4F (24)."
2967701
PHB1 affects PRPF8
2 |
PRPF8 binds PHB1. 2 / 2
2 |
biogrid
No evidence text available
27025967
biogrid
No evidence text available
28515276
PABPC1 affects PRPF8
2 |
PABPC1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
ORF9c affects PRPF8
2 |
ORF9c binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35180394
biogrid
No evidence text available
| DOI
NUDCD2 affects PRPF8
2 |
PRPF8 binds NUDCD2. 2 / 2
2 |
biogrid
No evidence text available
32665550
biogrid
No evidence text available
34079125
NPM1 affects PRPF8
2 |
PRPF8 binds NPM1. 2 / 2
2 |
biogrid
No evidence text available
39501047
biogrid
No evidence text available
28515276
NCL affects PRPF8
2 |
NCL binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
27049334
biogrid
No evidence text available
28515276
NCDN affects PRPF8
2 |
PRPF8 binds NCDN. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
MT-ATP6 affects PRPF8
| 2
Bloc1s3 binds MT-ATP6, PRPF8, and PRP8. 2 / 2
| 2
sparser
"Thus the Prp8p-Aar2p complex that accumulates in the prp8-rp mutants is nuclear and therefore, unlike the situation with ΔNLS-Prp8p, has the possibility to interact with Brr2p but does so with reduced efficiency as a consequence of the poor association of Brr2p with Prp8-rp mutant proteins."
17934474
sparser
"Compared to wild-type Prp8p ( xref ), the Prp8-rp mutant proteins were associated with less Brr2p ( xref , lanes 1-7) and with more Aar2p ( xref , lanes 9-13)."
17934474
MFAP1 affects PRPF8
2 |
MFAP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
40437099
biogrid
No evidence text available
37071682
METTL14 affects PRPF8
2 |
METTL14 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
29507755
biogrid
No evidence text available
36597993
MATR3 affects PRPF8
2 |
MATR3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
29511296
LUC7L2 affects PRPF8
2 |
PRPF8 binds LUC7L2. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28515276
LSM2 affects PRPF8
2 |
PRPF8 binds LSM2. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
29395067
LRRC59 affects PRPF8
2 |
PRPF8 binds LRRC59. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
32788342
LCN2 affects TMED9
| 2
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
KPNB1 affects PRPF8
2 |
PRPF8 binds KPNB1. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
KPNA4 affects PRPF8
2 |
PRPF8 binds KPNA4. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
26344197
KIAA1143 affects PRPF8
2 |
KIAA1143 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
IPO7 affects PRPF8
2 |
PRPF8 binds IPO7. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
IK affects PRPF8
2 |
PRPF8 binds IK. 2 / 2
2 |
biogrid
No evidence text available
39358380
biogrid
No evidence text available
28515276
HUWE1 affects PRPF8
2 |
HUWE1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
HSPA8 affects PRPF8
2 |
HSPA8 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
27684187
biogrid
No evidence text available
28515276
HSPA5 affects PRPF8
2 |
PRPF8 binds HSPA5. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
HSPA1A affects PRPF8
2 |
PRPF8 binds HSPA1A. 2 / 2
2 |
biogrid
No evidence text available
32687490
biogrid
No evidence text available
28515276
HSP90AA1 affects PRPF8
2 |
HSP90AA1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
19875381
biogrid
No evidence text available
28515276
HRES1 affects TMED9
| 2
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
HNRNPM affects PRPF8
2 |
HNRNPM binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
22939629
HNRNPK affects PRPF8
1 | 1
PRPF8 binds HNRNPK. 2 / 2
1 | 1
sparser
"These results suggested that C'2 and D are probably the functional domains, which affect the binding of snoRD126 to hnRNPK and PRPF8 proteins."
33891563
biogrid
No evidence text available
28515276
HNRNPH2 affects PRPF8
2 |
PRPF8 binds HNRNPH2. 2 / 2
2 |
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
HNRNPC affects PRPF8
2 |
PRPF8 binds HNRNPC. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28515276
HNRNPA1 affects PRPF8
2 |
HNRNPA1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
22446626
biogrid
No evidence text available
28515276
HMGB1 affects PRPF8
2 |
HMGB1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
29721183
biogrid
No evidence text available
35235311
HDLBP affects PRPF8
2 |
PRPF8 binds HDLBP. 2 / 2
2 |
biogrid
No evidence text available
36244648
biogrid
No evidence text available
28515276
HADHA affects PRPF8
2 |
PRPF8 binds HADHA. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
H4C16 affects PRPF8
2 |
PRPF8 binds H4C16. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
30804502
H2BC5 affects PRPF8
2 |
PRPF8 binds H2BC5. 2 / 2
2 |
biogrid
No evidence text available
31152661
biogrid
No evidence text available
31152661
H2BC21 affects PRPF8
2 |
H2BC21 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
30021884
biogrid
No evidence text available
35271311
G3BP2 affects PRPF8
2 |
PRPF8 binds G3BP2. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
34901782
FYV6 affects PRPF8
| 2
FYV6 binds PRPF8. 2 / 2
| 2
reach
"Genetic interactions between Fyv6 and Prp8 first or second-step alleles."
37625852
reach
"Genetic Interactions between Fyv6 and Prp8 1 st or 2 nd -Step Alleles."
36778415
FBXO22 affects PRPF8
2 |
PRPF8 binds FBXO22. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
36774506
EP300 affects PRPF8
2 |
EP300 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
33742100
biogrid
No evidence text available
30110629
EIF4G1 affects TMED9
| 2
TMED9 binds LCN2, HRES1, PRPF8, and EIF4G1. 2 / 2
| 2
sparser
"Chemical cross-linking of eIF-4F to cap-labeled mRNA, showed that phosphorylation increased the interaction of both the p25 and p220 subunits of eIF-4F with the 5' end of mRNA."
2002015
sparser
"J Biol Chem 266, 4669-4672 62 Bu X. Haas DW, Hagedorn CH (1993) Novel phosphorylation sites of eukaryotic initiation factor 4F and evidence that phosphorylation stabilizes interactions of the p25 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7880899
EIF4A3 affects PRPF8
2 |
EIF4A3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
23084401
biogrid
No evidence text available
28515276
EFTUD2 affects AAR2
| 2
PRPF8 binds AAR2 and EFTUD2. 2 / 2
| 2
sparser
"Collectively, these data provide strong support for the idea that PRPF8 associates with EFTUD2 and AAR2 early in its assembly pathway."
28515276
sparser
"These results support the idea that PRPF8, AAR2, and EFTUD2 form an assembly intermediate in human cells and that some of the mutants are trapped at this stage."
28515276
EEF1G affects PRPF8
2 |
PRPF8 binds EEF1G. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
EEF1D affects PRPF8
2 |
PRPF8 binds EEF1D. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
EBNA-LP affects PRPF8
1 1 |
PRPF8 binds EBNA-LP. 2 / 2
1 1 |
biogrid
No evidence text available
18457437
virhostnet
No evidence text available
18457437
DSG1 affects PRPF8
2 |
PRPF8 binds DSG1. 2 / 2
2 |
biogrid
No evidence text available
40437099
biogrid
No evidence text available
28515276
DNAJC17 affects PRPF8
2 |
PRPF8 binds DNAJC17. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
33957083
DHX8 affects PRPF8
1 | 1
PRPF8 binds DHX8. 2 / 2
1 | 1
biogrid
No evidence text available
28515276
sparser
"DHX8 also directly interacts with PRPF8 and plays a role in positioning the 3′ splice site for step II catalysis, and this is similar to what occurs after exon ligation, which is thought to bind and pull the 3′ sequences of the ligated exon, releasing the exon of the P complex ( xref ; xref ) ( xref )."
36609432
DHX38 affects PRPF8
2 |
PRPF8 binds DHX38. 2 / 2
2 |
biogrid
No evidence text available
37071682
biogrid
No evidence text available
28515276
DHX16 affects PRPF8
| 2
DHX16 binds PRPF8. 2 / 2
| 2
reach
"This flexible anchoring is conditioned by the hook of PRP2 binding to PRP8, the presence of which may serve as a signature for the occurrence of the translocation of PRP2."
37165190
reach
"Moreover, the clip of PRP2 replaced SNIP1 by interacting with the α3 helix of SKIP, whereas new interactions between PRP2 , SKIP and PRP8 replace those between BUD13 and SKIP in the B complex (Fig. 3a and Extended Data Fig. 4c,d)."
37165190
DDX5 affects PRPF8
1 | 1
PRPF8 binds DDX5. 2 / 2
1 | 1
biogrid
No evidence text available
28515276
reach
"Interactions between PRPF8, U2SURP, or DDX5 with SMG1 did not change in the presence or absence of radiation (Fig. 3D and E and Supplementary fig."
36921295
DDX3X affects PRPF8
2 |
DDX3X binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28515276
DDX21 affects PRPF8
2 |
DDX21 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
35831314
DDB1 affects PRPF8
2 |
PRPF8 binds DDB1. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
CWF19L1 affects PRPF8
2 |
PRPF8 binds CWF19L1. 2 / 2
2 |
biogrid
No evidence text available
28515276
biogrid
No evidence text available
34079125
CUL3 affects PRPF8
2 |
CUL3 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
21145461
biogrid
No evidence text available
35563538
COPS5 affects PRPF8
| 2
PRPF8 binds COPS5. 2 / 2
| 2
sparser
"In contrast, the C-terminal Jab1 domain of the large spliceosomal PRPF8 scaffold that can activate the SNRNP200 helicase directly binds the active NC xref , xref ."
37019967
sparser
"For crystallographic analyses, we used N-terminally truncated hBrr2 T1 in complex with the Jab1 domain of the hPrp8 protein lacking a Brr2-inhibiting C-terminal tail (hJab1 ΔC )."
34048711
CDC40 affects PRPF8
2 |
PRPF8 binds CDC40. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
26344197
CCP110 affects PRPF8
| 1 1
PRPF8 binds CCP110. 2 / 2
| 1 1
sparser
"Thus, LUBAC-catalyzed linear ubiquitin chains construct a CP110–PRPF8 complex in which PRPF8 takes CP110 away from the mother centriole to promote ciliogenesis."
34813648
reach
"Thus, LUBAC-catalyzed linear ubiquitin chains construct a CP110–PRPF8 complex in which PRPF8 takes CP110 away from the mother centriole to promote ciliogenesis."
34813648
CCNF affects PRPF8
2 |
CCNF binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
33729478
biogrid
No evidence text available
36114006
Bloc1s3 affects PRPF8
| 2
Bloc1s3 binds MT-ATP6, PRPF8, and PRP8. 2 / 2
| 2
sparser
"Thus the Prp8p-Aar2p complex that accumulates in the prp8-rp mutants is nuclear and therefore, unlike the situation with ΔNLS-Prp8p, has the possibility to interact with Brr2p but does so with reduced efficiency as a consequence of the poor association of Brr2p with Prp8-rp mutant proteins."
17934474
sparser
"Compared to wild-type Prp8p ( xref ), the Prp8-rp mutant proteins were associated with less Brr2p ( xref , lanes 1-7) and with more Aar2p ( xref , lanes 9-13)."
17934474
BUD31 affects PRPF8
2 |
PRPF8 binds BUD31. 2 / 2
2 |
biogrid
No evidence text available
37071682
biogrid
No evidence text available
34079125
BAP1 affects PRPF8
2 |
BAP1 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
34591877
biogrid
No evidence text available
35446349
BAG5 affects PRPF8
2 |
PRPF8 binds BAG5. 2 / 2
2 |
biogrid
No evidence text available
32850835
biogrid
No evidence text available
28515276
BAG2 affects PRPF8
2 |
PRPF8 binds BAG2. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
28515276
ANXA2 affects PRPF8
2 |
PRPF8 binds ANXA2. 2 / 2
2 |
biogrid
No evidence text available
30021884
biogrid
No evidence text available
28515276
ANLN affects PRPF8
2 |
ANLN binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
31586073
biogrid
No evidence text available
36526897
AGR2 affects PRPF8
2 |
AGR2 binds PRPF8. 2 / 2
2 |
biogrid
No evidence text available
30575818
biogrid
No evidence text available
30575818
AAR2 affects EFTUD2, and PRPF8
| 2
PRPF8 binds AAR2 and EFTUD2. 2 / 2
| 2
sparser
"Collectively, these data provide strong support for the idea that PRPF8 associates with EFTUD2 and AAR2 early in its assembly pathway."
28515276
sparser
"These results support the idea that PRPF8, AAR2, and EFTUD2 form an assembly intermediate in human cells and that some of the mutants are trapped at this stage."
28515276
3D affects PRPF8
| 2
3D binds PRPF8. 2 / 2
| 2
reach
"For example, 3D polymerase from enterovirus 71 directly binds to pre-mRNA processing factor 8 (PRPF8) and disrupts the pre-mRNA splicing processes, contributing to the invasion of the virus (Liu et al., 2014)."
36891156
reach
"In the case of picornaviruses, it has been shown recently that the viral polymerase 3D binds to PRPF8, a core components of U5, and blocks mRNA maturation, with the consequent accumulation of the lariat intermediate [XREF_BIBR]."
27575636
2,3,7,8-tetrachlorodibenzodioxine increases the amount of PRPF8. 2 / 2
2 |
ctd
No evidence text available
19770486
ctd
No evidence text available
17942748
4,4'-sulfonyldiphenol decreases the amount of PRPF8. 2 / 2
2 |
ctd
No evidence text available
36041667
ctd
No evidence text available
39298647
Valproic acid affects PRPF8
1 |
Valproic acid decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
15901671
Tungsten affects PRPF8
1 |
Tungsten decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
30912803
Triptonide affects PRPF8
1 |
Triptonide decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
33045310
Thiram affects PRPF8
1 |
Thiram decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
38568856
Sevoflurane affects PRPF8
1 |
Sevoflurane increases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
35249202
Reactive nitrogen species activates PRPF8. 1 / 1
| 1
reach
"Mutagenesis of active site residues C1 and H169 abolished the binding of cisplatin to the Prp8 intein.In addition to metal-containing inhibitors, reactive nitrogen species compounds (DEA NONOate at 1.2 mM and 12 mM) and Angeli's salt at 2 mM and 20 mM) were found to inhibit splicing of the C. neoformans Prp8 intein in an in vitro Prp8 intein splicing assay, whereas H 2 O 2 (.8 and 8 mM) did not ."
35211511
Perfluorooctane-1-sulfonic acid decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
36331819
P.R86M variant affects PRPF8
| 1
P.R86M variant inhibits PRPF8. 1 / 1
| 1
reach
"It is conceivable that the p.R86M variant disrupts PRPF8 function, potentially leading to impaired splicing activity."
40066647
LncRNA affects PRPF8
| 1
LncRNA activates PRPF8. 1 / 1
| 1
reach
"Furthermore, lncRNA ASCO contributed to the assembly of key splicing composition PREMRNA PROCESSING 8 (PRP8) and SmD1, which influenced the binding of PRP8 to a subset of its pre-mRNA targets in Arabidopsis [63]."
38156284
Hsa-miR-532-3p affects PRPF8
1 |
Hsa-miR-532-3p decreases the amount of PRPF8. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-361-5p affects PRPF8
1 |
Hsa-miR-361-5p decreases the amount of PRPF8. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-27b-3p affects PRPF8
1 |
Hsa-miR-27b-3p decreases the amount of PRPF8. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-196a-5p affects PRPF8
1 |
Hsa-miR-196a-5p decreases the amount of PRPF8. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-16-5p affects PRPF8
1 |
Hsa-miR-16-5p decreases the amount of PRPF8. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
HBrr2 proteins affects PRPF8
| 1
PRPF8 binds hBrr2 proteins. 1 / 1
| 1
reach
"The level of free hBrr2 was unchanged (Fig. 2C, bottom panel), and both PRPF8 and hBrr2 proteins complexed in stoichiometric amounts suggesting that the human tri-snRNP complex is stable under physiological conditions in RPE cells."
38605034
Folic acid affects PRPF8
1 |
Folic acid methylates PRPF8. 1 / 1
1 |
ctd
No evidence text available
20938992
Docking protein-1 affects PRPF8
| 1
Docking protein-1 binds PRPF8 and EIF4G1. 1 / 1
| 1
sparser
"As a polymeric protein, pp62 protein is co-assembled with another polymeric protein, pp220, to form the inner core shell of ASFV ( xref )."
35097046
Dicrotophos affects PRPF8
1 |
Dicrotophos increases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
28302478
Choline affects PRPF8
1 |
Choline methylates PRPF8. 1 / 1
1 |
ctd
No evidence text available
20938992
Bisphenol B affects PRPF8
1 |
Bisphenol B increases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
34186270
Arsenous acid affects PRPF8
1 |
Arsenous acid increases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
15894607
Arsenic atom affects PRPF8
1 |
Arsenic atom increases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
39836092
Ametryn affects PRPF8
1 |
Ametryn decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
29427468
ZBTB46 affects PRPF8
1 |
ZBTB46 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26186194
YWHAQ affects PRPF8
1 |
PRPF8 binds YWHAQ. 1 / 1
1 |
biogrid
No evidence text available
28515276
WWP2 affects PRPF8
1 |
WWP2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31048545
WWOX affects PRPF8
1 |
WWOX binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24550385
WDR5 affects PRPF8
1 |
WDR5 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33022573
VIM affects PRPF8
1 |
PRPF8 binds VIM. 1 / 1
1 |
biogrid
No evidence text available
28515276
VARS1 affects PRPF8
1 |
PRPF8 binds VARS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
UXT affects PRPF8
1 |
PRPF8 binds UXT. 1 / 1
1 |
biogrid
No evidence text available
28515276
USP36 affects PRPF8
1 |
USP36 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
36912080
UHRF1 affects PRPF8
1 |
UHRF1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
28803780
UBE2I affects PRPF8
1 |
UBE2I binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
19596686
UBC affects PRPF8
1 |
PRPF8 binds UBC. 1 / 1
1 |
biogrid
No evidence text available
20595234
U4/U6 di-snRNP proteins affects PRPF8
| 1
U4/U6 di-snRNP proteins activates PRPF8. 1 / 1
| 1
reach
"The subsequent association of the U4/U6 di-snRNP proteins and USP39 could promote the stable association of the PRP6 N-terminal regions along PRP8 , PRP8 α-helical bundle (PRP8 ), and PRP8 domains (Extended Data Fig. 4f)."
38467876
U2AF1 affects SF3B1
| 1
PRPF8 binds PRPF3, U2AF1, and SF3B1. 1 / 1
| 1
sparser
"Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, xref )."
28703423
TXNL1 affects PRPF8
1 |
PRPF8 binds TXNL1. 1 / 1
1 |
biogrid
No evidence text available
34079125
TXNDC5 affects PRPF8
1 |
PRPF8 binds TXNDC5. 1 / 1
1 |
biogrid
No evidence text available
28515276
TRIM55 affects PRPF8
1 |
PRPF8 binds TRIM55. 1 / 1
1 |
biogrid
No evidence text available
22939629
TRIM31 affects PRPF8
1 |
TRIM31 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
34650049
TRIM28 affects PRPF8
1 |
TRIM28 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
29955894
TPS-sab affects RBM22
| 1
TPS-sab binds RBM22 and PRPF8. 1 / 1
| 1
sparser
"At 5’ SSs, RBM22 and PRPF8 were bound at the exonic end, which has been shown to be critical for splicesome assembly [ xref , xref ]."
32584815
TPM3 affects PRPF8
1 |
TPM3 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33961781
TECPR1 affects PRPF8
1 |
PRPF8 binds TECPR1. 1 / 1
1 |
biogrid
No evidence text available
30021884
SRP9 affects PRPF8
1 |
PRPF8 binds SRP9. 1 / 1
1 |
biogrid
No evidence text available
28515276
SOX2 affects PRPF8
1 |
SOX2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
34732716
SNW1 affects CWC15
| 1
SNW1 binds CWC15 and PRPF8. 1 / 1
| 1
sparser
"Finally, PPIG interacts with SNW1, CWC15, and PRPF8, all through the isomerase domain ( xref )."
30518120
SNRNP200 affects LAP
| 1
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
SLC25A5 affects PRPF8
1 |
PRPF8 binds SLC25A5. 1 / 1
1 |
biogrid
No evidence text available
28515276
SLC25A10 affects PRPF8
1 |
PRPF8 binds SLC25A10. 1 / 1
1 |
biogrid
No evidence text available
28515276
SLC25A1 affects PRPF8
1 |
PRPF8 binds SLC25A1. 1 / 1
1 |
biogrid
No evidence text available
28515276
SIRT6 affects PRPF8
1 |
SIRT6 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24169447
SF3B1 affects U2AF1
| 1
PRPF8 binds PRPF3, U2AF1, and SF3B1. 1 / 1
| 1
sparser
"Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, xref )."
28703423
SERPINB6 affects PRPF8
1 |
PRPF8 binds SERPINB6. 1 / 1
1 |
biogrid
No evidence text available
28515276
SEPTIN7 affects PRPF8
1 |
PRPF8 binds SEPTIN7. 1 / 1
1 |
biogrid
No evidence text available
22939629
SEC16A affects PRPF8
1 |
PRPF8 binds SEC16A. 1 / 1
1 |
biogrid
No evidence text available
28515276
S affects PRPF8
1 |
S binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
39147351
RRM1 affects PRPF8
| 1
RRM1 activates PRPF8. 1 / 1
| 1
reach
"PRPF8, SNRNP200, GTPBP4, SMCHD1, DHX15, PRPF6, A8KAP3, DHX9 and EPRS were significantly reduced by RRM1 or ZnF1 deletion with no trend of> 2-fold for any other deletion mutant (Supplemental Table S4)."
29511296
RREB1 affects PRPF8
1 |
PRPF8 binds RREB1. 1 / 1
1 |
biogrid
No evidence text available
30021884
RPS9 affects PRPF8
1 |
PRPF8 binds RPS9. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPS4X affects PRPF8
1 |
PRPF8 binds RPS4X. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPS3 affects PRPF8
1 |
PRPF8 binds RPS3. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPS23 affects PRPF8
1 |
PRPF8 binds RPS23. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPS20 affects PRPF8
1 |
PRPF8 binds RPS20. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPS17 affects PRPF8
1 |
PRPF8 binds RPS17. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPS13 affects PRPF8
1 |
PRPF8 binds RPS13. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPS12 affects PRPF8
1 |
PRPF8 binds RPS12. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPLP1 affects PRPF8
1 |
PRPF8 binds RPLP1. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL9 affects PRPF8
1 |
PRPF8 binds RPL9. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL8 affects PRPF8
1 |
PRPF8 binds RPL8. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL38 affects PRPF8
1 |
PRPF8 binds RPL38. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL26 affects PRPF8
1 |
PRPF8 binds RPL26. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL23 affects PRPF8
1 |
PRPF8 binds RPL23. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL21 affects PRPF8
1 |
PRPF8 binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL14 affects PRPF8
1 |
PRPF8 binds RPL14. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL12 affects PRPF8
1 |
PRPF8 binds RPL12. 1 / 1
1 |
biogrid
No evidence text available
28515276
RPL10 affects PRPF8
1 |
PRPF8 binds RPL10. 1 / 1
1 |
biogrid
No evidence text available
28515276
RNU12 affects PRPF8
1 |
RNU12 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
15146077
RCC2 affects PRPF8
1 |
PRPF8 binds RCC2. 1 / 1
1 |
biogrid
No evidence text available
28515276
RC3H2 affects PRPF8
1 |
RC3H2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30209976
RC3H1 affects PRPF8
1 |
RC3H1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30209976
RBM8A affects PRPF8
1 |
RBM8A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35271311
RBM6 affects PRPF8
1 |
RBM6 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35271311
RBM22 affects TPS-sab
| 1
TPS-sab binds RBM22 and PRPF8. 1 / 1
| 1
sparser
"At 5’ SSs, RBM22 and PRPF8 were bound at the exonic end, which has been shown to be critical for splicesome assembly [ xref , xref ]."
32584815
RANBP2 affects PRPF8
1 |
PRPF8 binds RANBP2. 1 / 1
1 |
biogrid
No evidence text available
26344197
RALY affects PRPF8
1 |
RALY binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26344197
RAB27A affects PRPF8
1 |
RAB27A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30833792
R2TP affects EFTUD2
| 1
R2TP binds PRPF8 and EFTUD2. 1 / 1
| 1
sparser
"Depletion of U5 proteins and PRPF8 RP mutation both increase the association of PRPF8 and EFTUD2 with R2TP."
28515276
Pqbp1 affects PRPF8
1 |
Pqbp1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26496610
Pectins affects PRPF8
1 |
Pectins decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
36331819
PSME2 affects PRPF8
1 |
PRPF8 binds PSME2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PSMB2 affects PRPF8
1 |
PRPF8 binds PSMB2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects translation
| 1
PRPF8 activates translation. 1 / 1
| 1
reach
"However, this raises an interesting question: if μ2 only blocks translation, how can it induce such a sharp decrease in PRPF8 (80%), as recently described [16], during the course of a 16 h infection?"
36614170
PRPF8 affects prp16-R686I
| 1
PRPF8 inhibits prp16-R686I. 1 / 1
| 1
reach
"These prp8 alleles significantly suppress growth defects of prp16-302 allele (Fig. 4B), and most of them (prp8-F331L, Y356C, Y590C/F, K603I, K611I/T, and S613T) also correct growth defects of prp16-R686I, demonstrating the generality of these effects (Fig. 4C)."
38876504
PRPF8 affects proliferative migratory invasive hepatic astrocytes
| 1
PRPF8 activates proliferative migratory invasive hepatic astrocytes. 1 / 1
| 1
eidos
"Collectively , Prp8 promoted the proliferative , migratory and invasive abilities of hepatic astrocytes ."
32547101
PRPF8 inhibits necroptotic process. 1 / 1
| 1
reach
"Nevertheless, the observation that depletion of PRPF8 triggers necroptosis raises further important questions."
36560714
PRPF8 affects lysis
| 1
PRPF8 inhibits lysis. 1 / 1
| 1
sparser
"However, the plasmids p182, p186, and p220 (Lac+R+) could inhibit the visible lysis of all the 30 phages in S. typhimurium."
3107002
PRPF8 activates intein-mediated protein splicing. 1 / 1
| 1
reach
"The recent discovery of a small molecule inhibitor of the Prp8 intein that selectively inhibits splicing without targeting proteases and inhibits the growth of intein-containing C. gattii and C. neoformans is a particularly exciting breakthrough that suggests intein inhibitors may have therapeutic benefits (Li et al., 2021)."
34692773
PRPF8 affects helicase
| 1
PRPF8 inhibits helicase. 1 / 1
| 1
reach
"Thus, how BRCA2 inactivation may increase intracellular ROS levels remains an open question.A further clue to the link between BRCA2 deficiency and ROS accumulation comes from our observation that depletion of the R-loop helicase, SETX, or the spliceosome factor, PRPF8, also suffices to induce endogenous oxidative stress and mitochondrial defects (Figure 7)."
34348152
PRPF8 affects hBrr2 proteins
| 1
PRPF8 binds hBrr2 proteins. 1 / 1
| 1
reach
"The level of free hBrr2 was unchanged (Fig. 2C, bottom panel), and both PRPF8 and hBrr2 proteins complexed in stoichiometric amounts suggesting that the human tri-snRNP complex is stable under physiological conditions in RPE cells."
38605034
PRPF8 affects hBrr2
| 1
PRPF8 inhibits hBrr2. 1 / 1
| 1
reach
"PRPF8 RP patient mutations, through dysregulation of hBrr2 by PRPF8, therefore provide a valuable opportunity to delineate regulatory mechanisms of hBrr2 on human splicing in health and disease."
38605034
PRPF8 affects europium atom
| 1
PRPF8 inhibits europium atom. 1 / 1
| 1
reach
"The knock-down of the spliceosomal components IK (72), CWC22 (73), PRP8 (74), BCAS2 (75), CRNKL1 (76) and AQR (77), as well as the splicing factor SRSF10 (78) reduced EU incorporation in U2OS cells."
39698826
PRPF8 affects docking protein-1
| 1
Docking protein-1 binds PRPF8 and EIF4G1. 1 / 1
| 1
sparser
"As a polymeric protein, pp62 protein is co-assembled with another polymeric protein, pp220, to form the inner core shell of ASFV ( xref )."
35097046
PRPF8 affects curcumin-induced apoptosis HCT116 cells
| 1
PRPF8 inhibits curcumin-induced apoptosis HCT116 cells. 1 / 1
| 1
eidos
"Subsequently , we repeated the assays outlined in Fig. 1 and found that PRP8 was not able to inhibit curcumin-induced apoptosis in HCT116 cells ( Fig. 2B-2E ) ."
32576716
PRPF8 affects cell viability cells
| 1
PRPF8 activates cell viability cells. 1 / 1
| 1
eidos
"CCK8 and colony formation assay revealed that loss of Prp8 reduced cell proliferation and viability in Hep3B cells ( P < 0.01 , Figure 3D and E ) ."
32547101
PRPF8 affects androgen receptors
| 1
PRPF8 leads to the deubiquitination of androgen receptors. 1 / 1
| 1
reach
"Additionally, knockdown of PRPF8 increases the polyubiquitination of endogenous androgen receptors [65], which could serve as a potential mechanism through which PRPF8 regulates androgen receptor activity."
40136404
PRPF8 affects ZBTB46
1 |
ZBTB46 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26186194
PRPF8 affects YWHAQ
1 |
PRPF8 binds YWHAQ. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects WWP2
1 |
WWP2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31048545
PRPF8 affects WWOX
1 |
WWOX binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24550385
PRPF8 affects WDR5
1 |
WDR5 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33022573
PRPF8 affects VIM
1 |
PRPF8 binds VIM. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects VARS1
1 |
PRPF8 binds VARS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects UXT
1 |
PRPF8 binds UXT. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects USP36
1 |
USP36 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
36912080
PRPF8 affects UHRF1
1 |
UHRF1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
28803780
PRPF8 affects UBE2I
1 |
UBE2I binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
19596686
PRPF8 affects UBC
1 |
PRPF8 binds UBC. 1 / 1
1 |
biogrid
No evidence text available
20595234
PRPF8 affects U2AF1
| 1
PRPF8 binds PRPF3, U2AF1, and SF3B1. 1 / 1
| 1
sparser
"Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, xref )."
28703423
PRPF8 affects U1/5′ss
| 1
Mutated PRPF8 inhibits U1/5′ss. 1 / 1
| 1
reach
"The fact that the U4-cs1 mutation, which blocks splicing at low temperature by hyperstabilizing the U4/U6 duplex [71] , becomes synthetically lethal in combination with either brr2 - 1 or prp28 - 1 mu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23454554
PRPF8 affects TXNL1
1 |
PRPF8 binds TXNL1. 1 / 1
1 |
biogrid
No evidence text available
34079125
PRPF8 affects TXNDC5
1 |
PRPF8 binds TXNDC5. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects TWIST1
| 1
PRPF8 activates TWIST1. 1 / 1
| 1
reach
"Knockout of the Rp13 proteasomal component impairs the ability of SCs to proliferate, survive, and differentiate, resulting in defective muscle regeneration ."
32152291
PRPF8 affects TRIM55
1 |
PRPF8 binds TRIM55. 1 / 1
1 |
biogrid
No evidence text available
22939629
PRPF8 affects TRIM31
1 |
TRIM31 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
34650049
PRPF8 affects TRIM28
1 |
TRIM28 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
29955894
PRPF8 affects TPS-sab
| 1
TPS-sab binds RBM22 and PRPF8. 1 / 1
| 1
sparser
"At 5’ SSs, RBM22 and PRPF8 were bound at the exonic end, which has been shown to be critical for splicesome assembly [ xref , xref ]."
32584815
PRPF8 affects TPM3
1 |
TPM3 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33961781
PRPF8 affects TECPR1
1 |
PRPF8 binds TECPR1. 1 / 1
1 |
biogrid
No evidence text available
30021884
PRPF8 affects SRP9
1 |
PRPF8 binds SRP9. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects SOX2
1 |
SOX2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
34732716
PRPF8 affects SLC25A5
1 |
PRPF8 binds SLC25A5. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects SLC25A10
1 |
PRPF8 binds SLC25A10. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects SLC25A1
1 |
PRPF8 binds SLC25A1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects SIRT6
1 |
SIRT6 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24169447
PRPF8 affects SERPINB6
1 |
PRPF8 binds SERPINB6. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects SEPTIN7
1 |
PRPF8 binds SEPTIN7. 1 / 1
1 |
biogrid
No evidence text available
22939629
PRPF8 affects SEC16A
1 |
PRPF8 binds SEC16A. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects S
1 |
S binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
39147351
PRPF8 activates Retinal Pigment Epithelium. 1 / 1
| 1
reach
"Graziotto et al. and Farkas et al. demonstrated that PRPF3, PRPF8 and PRPF31 mutations could cause dysfunction of RPE XREF_BIBR XREF_BIBR."
28216641
PRPF8 affects RREB1
1 |
PRPF8 binds RREB1. 1 / 1
1 |
biogrid
No evidence text available
30021884
PRPF8 affects RPS9
1 |
PRPF8 binds RPS9. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPS4X
1 |
PRPF8 binds RPS4X. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPS23
1 |
PRPF8 binds RPS23. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPS20
1 |
PRPF8 binds RPS20. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPS17
1 |
PRPF8 binds RPS17. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPS13
1 |
PRPF8 binds RPS13. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPS12
1 |
PRPF8 binds RPS12. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPLP1
1 |
PRPF8 binds RPLP1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL9
1 |
PRPF8 binds RPL9. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL8
1 |
PRPF8 binds RPL8. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL38
1 |
PRPF8 binds RPL38. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL26
1 |
PRPF8 binds RPL26. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL23
1 |
PRPF8 binds RPL23. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL21
1 |
PRPF8 binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL14
1 |
PRPF8 binds RPL14. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL12
1 |
PRPF8 binds RPL12. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RPL10
1 |
PRPF8 binds RPL10. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RNaseH D10R-E48R
| 1
PRPF8 activates RNaseH D10R-E48R. 1 / 1
| 1
reach
"Thus, depletion of PRPF8 and PlaB treatment each cause an increase in chromatin bound RNaseH D10R-E48R, which is consistent with an accumulation of R-loops."
29212152
PRPF8 affects RNU12
1 |
RNU12 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
15146077
PRPF8 affects RNF113A
1 |
RNF113A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35819319
PRPF8 affects RCC2
1 |
PRPF8 binds RCC2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects RC3H2
1 |
RC3H2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30209976
PRPF8 affects RC3H1
1 |
RC3H1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30209976
PRPF8 affects RBM8A
1 |
RBM8A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35271311
PRPF8 affects RBM6
1 |
RBM6 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35271311
PRPF8 affects RBM22, and TPS-sab
| 1
TPS-sab binds RBM22 and PRPF8. 1 / 1
| 1
sparser
"At 5’ SSs, RBM22 and PRPF8 were bound at the exonic end, which has been shown to be critical for splicesome assembly [ xref , xref ]."
32584815
PRPF8 affects RANBP2
1 |
PRPF8 binds RANBP2. 1 / 1
1 |
biogrid
No evidence text available
26344197
PRPF8 affects RALY
1 |
RALY binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26344197
PRPF8 affects RAB27A
1 |
RAB27A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30833792
PRPF8 affects Pqbp1
1 |
Pqbp1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26496610
PRPF8 affects PSME2
1 |
PRPF8 binds PSME2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects PSMB2
1 |
PRPF8 binds PSMB2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects PRCC
1 |
PRPF8 binds PRCC. 1 / 1
1 |
biogrid
No evidence text available
34079125
PRPF8 affects PPP1CC
1 |
PPP1CC binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30344098
PRPF8 affects POLR2E
1 |
PRPF8 binds POLR2E. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects PKP1
1 |
PRPF8 binds PKP1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects PKM
1 |
PRPF8 binds PKM. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects PIP4K2C
1 |
PRPF8 binds PIP4K2C. 1 / 1
1 |
biogrid
No evidence text available
26344197
PRPF8 affects PGAM5
1 |
PRPF8 binds PGAM5. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects PDIA6
1 |
PRPF8 binds PDIA6. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects PB1
1 |
PRPF8 binds PB1. 1 / 1
1 |
virhostnet
No evidence text available
25464832
PRPF8 affects PAGE4
1 |
PAGE4 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32698014
PRPF8 affects ORF57
1 |
ORF57 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35545047
PRPF8 affects OBSL1
1 |
OBSL1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24711643
PRPF8 affects NUPR1
1 |
NUPR1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32780723
PRPF8 affects NT5C2
1 |
NT5C2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35831314
PRPF8 affects NR2C2
1 |
NR2C2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30463901
PRPF8 affects NOTCH1
1 |
NOTCH1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
23022380
PRPF8 affects NAP1L4
| 1
PRPF8 decreases the amount of NAP1L4. 1 / 1
| 1
reach
"qRT–PCR revealed decreased expression of circNAP1L4 and increased expression of linear NAP1L4 under hypoxia, which was reversed by PRP8 siRNA transfection, suggesting that the output of circNAP1L4 and linear NAP1L4 was mediated by PRP8 under hypoxia (Figure 6C)."
39102213
PRPF8 affects NA
1 |
PRPF8 binds NA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
PRPF8 inhibits Myelodysplastic Syndromes. 1 / 1
| 1
reach
"For example, the U5 component PRPF8, required for a catalytic step in pre-mRNA splicing, has functionally reduced protein levels in many myelodysplastic syndromes because of mutations or deletions."
36979496
PRPF8 affects MYCN
1 |
MYCN binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35013218
PRPF8 affects MYBBP1A
1 |
MYBBP1A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26344197
PRPF8 affects MLKL
| 1
PRPF8 increases the amount of MLKL. 1 / 1
| 1
reach
"Surprisingly, PRPF8 KD led to a considerable amount of pMLKL in the absence of infection, revealing that the enhanced cell death observed with this KD (Figure 2B) could be attributable, at least in part, to necroptosis (Figure 3A,B)."
36560714
PRPF8 affects MIF
1 |
PRPF8 binds MIF. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects MEN1
1 |
MEN1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35850772
PRPF8 affects MED12
1 |
MED12 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26344197
PRPF8 affects MCM5
1 |
MCM5 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
25963833
PRPF8 affects MARS1
1 |
PRPF8 binds MARS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects MAGOH
1 |
MAGOH binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
23084401
PRPF8 affects M
1 |
PRPF8 binds M. 1 / 1
1 |
virhostnet
No evidence text available
25464832
PRPF8 affects LUC7L3
1 |
PRPF8 binds LUC7L3. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects LSM4
1 |
PRPF8 binds LSM4. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects LOXL2
1 |
LOXL2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31409639
PRPF8 affects LMNA
1 |
PRPF8 binds LMNA. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects LGALS7B
1 |
PRPF8 binds LGALS7B. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects LDHB
1 |
PRPF8 binds LDHB. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects LARP7
1 |
LARP7 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26725010
PRPF8 affects LAP
| 1
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
PRPF8 affects KRT8
1 |
PRPF8 binds KRT8. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects KRT18
1 |
PRPF8 binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects KRT15
1 |
PRPF8 binds KRT15. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects KIF23
1 |
KIF23 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31586073
PRPF8 affects IQGAP1
1 |
PRPF8 binds IQGAP1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects ILF2
1 |
PRPF8 binds ILF2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects IGLC3
1 |
PRPF8 binds IGLC3. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects HSPA9
1 |
PRPF8 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects HSPA6
1 |
PRPF8 binds HSPA6. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects HSP90AB1
1 |
PRPF8 binds HSP90AB1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects HNRNPCL2
1 |
HNRNPCL2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33961781
PRPF8 affects HEXIM1
1 |
HEXIM1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
29845934
PRPF8 affects H3K9me3
| 1
PRPF8 activates H3K9me3. 1 / 1
| 1
reach
"Namely, we find that PRPF8 depletion and PlaB treatment cause a marked reduction in H3K9Ac and H4K16Ac, but not H3K9me3."
29212152
PRPF8 affects H2BC18
1 |
H2BC18 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30021884
PRPF8 affects H/ACA box snoRNAs
| 1
H/ACA box snoRNAs binds PRPF8. 1 / 1
| 1
reach
"In addition, we found increased binding of PRPF8 to C/D and H/ACA box snoRNAs in RP13 retinal cells."
38605034
PRPF8 affects GTF2I
1 |
PRPF8 binds GTF2I. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects GOLGA4
1 |
PRPF8 binds GOLGA4. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects GLS
1 |
GLS binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30021884
PRPF8 affects GIGYF2
1 |
GIGYF2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
20696395
PRPF8 affects FZR1
1 |
FZR1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33306668
PRPF8 affects FLG2
1 |
PRPF8 binds FLG2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects EZH2
1 |
EZH2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
36517590
PRPF8 affects ESR1
1 |
ESR1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26487511
PRPF8 affects ERCC6
1 |
ERCC6 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26030138
PRPF8 affects EPRS1
1 |
PRPF8 binds EPRS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects ELOC
1 |
PRPF8 binds ELOC. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects EIF3K
1 |
PRPF8 binds EIF3K. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects EIF2S3
1 |
PRPF8 binds EIF2S3. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects EEF1A1P5
1 |
PRPF8 binds EEF1A1P5. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects EBNA1BP2
1 |
PRPF8 binds EBNA1BP2. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects E-cadherin HCC Hep3B cells
| 1
PRPF8 inhibits E-cadherin HCC Hep3B cells. 1 / 1
| 1
eidos
"Conversely , Prp8 knockdown reduced the expression levels of N-cadherin and Vimentin , and increased the expression of E-cadherin in HCC Hep3B cells ( Figure 4C and D ) ."
32547101
PRPF8 affects DUSP2
1 |
DUSP2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
28675297
PRPF8 affects DPM1
1 |
PRPF8 binds DPM1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects DNAJB4
1 |
PRPF8 binds DNAJB4. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects DHX30
1 |
PRPF8 binds DHX30. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects DENR
| 1
PRPF8 binds DENR. 1 / 1
| 1
sparser
"Genes encoding proteins similar to NBS–LRR-type resistance proteins, such as r NBS41 , YR48 Nbs1-Pi9 , RGA3, RPP8 and DRP-RP13, were found in MQTL2.1, MQTL5.3, MQTL6.3, MQTL11.1, MQTL11.8 and MQTL11.9, respectively."
39013915
PRPF8 affects DDX46
1 |
PRPF8 binds DDX46. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects DARS1
1 |
PRPF8 binds DARS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects Cebpb
1 |
Cebpb binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30884312
PRPF8 affects Ccdc12
1 |
Ccdc12 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26496610
PRPF8 affects Carcinogenesis
| 1
Mutated PRPF8 activates Carcinogenesis. 1 / 1
| 1
reach
"Identifying specific splicing alterations in tumorigenesis driven by PRPF8 mutations could serve as biomarkers for early diagnosis and prediction of therapeutic responses."
40136404
PRPF8 affects CWC15
| 1
SNW1 binds CWC15 and PRPF8. 1 / 1
| 1
sparser
"Finally, PPIG interacts with SNW1, CWC15, and PRPF8, all through the isomerase domain ( xref )."
30518120
PRPF8 affects CUL7
1 |
CUL7 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24711643
PRPF8 affects CSTPP1
1 |
PRPF8 binds CSTPP1. 1 / 1
1 |
biogrid
No evidence text available
34079125
PRPF8 affects COPS2
1 |
COPS2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35831314
PRPF8 affects CHMP4B
1 |
CHMP4B binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31586073
PRPF8 affects CEBPB
1 |
CEBPB binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30884312
PRPF8 affects CDKN1A
| 1
PRPF8 activates CDKN1A. 1 / 1
| 1
reach
"Functionally, PIRH2B KD partially rescues the reduction in cell numbers and upregulation of P21 caused by PRPF8 KD in hESCs."
37357506
PRPF8 affects CAPRIN1
1 |
PRPF8 binds CAPRIN1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects C9orf72
1 |
C9orf72 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
37317656
PRPF8 affects BRD4
1 |
BRD4 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32416067
PRPF8 affects BP
| 1
PRPF8 binds BP. 1 / 1
| 1
reach
"It then facilitates the delocalization of Prp8, which was binding the 5′-SS and BP to make it bind both 5′-SS and 3′-SS, and it stabilizes this new conformation."
35885562
PRPF8 affects BAG3
1 |
PRPF8 binds BAG3. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects ATP5F1B
1 |
PRPF8 binds ATP5F1B. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects ATG5
1 |
ATG5 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
37054706
PRPF8 affects ASXL1
1 |
ASXL1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32683582
PRPF8 affects ARSI
| 1
PRPF8 activates ARSI. 1 / 1
| 1
reach
"The constituents of the autonomous pathway, FCA, FY, FPA, the cleavage polyadenylation machinery components CstF64 and CstF77, and the spliceosome factor PRP8, promote the choice of proximal polyadeny[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26342908
PRPF8 affects ALYREF
1 |
PRPF8 binds ALYREF. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects ALDOA
1 |
PRPF8 binds ALDOA. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF8 affects AHNAK
1 |
PRPF8 binds AHNAK. 1 / 1
1 |
biogrid
No evidence text available
28515276
PRPF3 affects U2AF1
| 1
PRPF8 binds PRPF3, U2AF1, and SF3B1. 1 / 1
| 1
sparser
"Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, xref )."
28703423
PRCC affects PRPF8
1 |
PRPF8 binds PRCC. 1 / 1
1 |
biogrid
No evidence text available
34079125
PPP1CC affects PRPF8
1 |
PPP1CC binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30344098
POLR2E affects PRPF8
1 |
PRPF8 binds POLR2E. 1 / 1
1 |
biogrid
No evidence text available
28515276
Pre-mRNA splicing factor binds PRPF3, PRPF8, PRPF31, RP9, and PLIN2. 1 / 1
| 1
sparser
"Trans-acting splicing mutations associated with adRP have also been found, and mutations in the pre-mRNA splicing factors PRPF3, PRPF8, PRPF31, and RP9 are associated with adRP in several populations."
18412284
PLIN2 affects PRPF3, PRPF31, PRPF8, REG3A, SNRNP200, and TOPORS
| 1
PRPF8 binds PRPF31, PRPF3, REG3A, TOPORS, SNRNP200, and PLIN2. 1 / 1
| 1
sparser
"Among the genes involved in mRNA splicing, mutations in PRPC8 (human homolog of yeast pre-mRNA splicing factor C8), PRP31 (human homolog of yeast pre-mRNA splicing factor 31), HPRP3 (human homolog of yeast pre-mRNA splicing factor 3), PAP-1 (PIM-1 kinase), TOPORS (topoisomerase-I-binding arginine/serine-rich protein) and SNRNP200 (small nuclear ribonucleoprotein, 200 kDa) are associated with adRP [ xref - xref ], although the mechanisms behind the process remain unclear."
20519033
PKP1 affects PRPF8
1 |
PRPF8 binds PKP1. 1 / 1
1 |
biogrid
No evidence text available
28515276
PKM affects PRPF8
1 |
PRPF8 binds PKM. 1 / 1
1 |
biogrid
No evidence text available
28515276
PIP4K2C affects PRPF8
1 |
PRPF8 binds PIP4K2C. 1 / 1
1 |
biogrid
No evidence text available
26344197
PHY1 affects PRPF8
| 1
PHY1 phosphorylates PRPF8. 1 / 1
| 1
sparser
"Protein kinase C and cAMP dependent protein kinase phosphorylate p220 of elF-4F at a more rapid rate than p25 of elF-4F (24)."
2967701
PGAM5 affects PRPF8
1 |
PRPF8 binds PGAM5. 1 / 1
1 |
biogrid
No evidence text available
28515276
PDIA6 affects PRPF8
1 |
PRPF8 binds PDIA6. 1 / 1
1 |
biogrid
No evidence text available
28515276
PBRM1 affects PRPF8
| 1
PBRM1 increases the amount of PRPF8. 1 / 1
| 1
reach
"Further investigation revealed that the expression of viral NS1 or PB1 triggered the elevation of PRPF8 levels [176]."
| PMC
PB1 affects PRPF8
1 |
PRPF8 binds PB1. 1 / 1
1 |
virhostnet
No evidence text available
25464832
PAGE4 affects PRPF8
1 |
PAGE4 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32698014
ORF57 affects PRPF8
1 |
ORF57 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35545047
OBSL1 affects PRPF8
1 |
OBSL1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24711643
NUPR1 affects PRPF8
1 |
NUPR1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32780723
NT5C2 affects PRPF8
1 |
NT5C2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35831314
NR2C2 affects PRPF8
1 |
NR2C2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30463901
NOTCH1 affects PRPF8
1 |
NOTCH1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
23022380
NA affects PRPF8
1 |
PRPF8 binds NA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
MYCN affects PRPF8
1 |
MYCN binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35013218
MYBBP1A affects PRPF8
1 |
MYBBP1A binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26344197
MIF affects PRPF8
1 |
PRPF8 binds MIF. 1 / 1
1 |
biogrid
No evidence text available
28515276
MEN1 affects PRPF8
1 |
MEN1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35850772
MED12 affects PRPF8
1 |
MED12 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26344197
MCM5 affects PRPF8
1 |
MCM5 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
25963833
MARS1 affects PRPF8
1 |
PRPF8 binds MARS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
MAGOH affects PRPF8
1 |
MAGOH binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
23084401
M affects PRPF8
1 |
PRPF8 binds M. 1 / 1
1 |
virhostnet
No evidence text available
25464832
LUC7L3 affects PRPF8
1 |
PRPF8 binds LUC7L3. 1 / 1
1 |
biogrid
No evidence text available
28515276
LSM4 affects PRPF8
1 |
PRPF8 binds LSM4. 1 / 1
1 |
biogrid
No evidence text available
28515276
LOXL2 affects PRPF8
1 |
LOXL2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31409639
LMNA affects PRPF8
1 |
PRPF8 binds LMNA. 1 / 1
1 |
biogrid
No evidence text available
28515276
LGALS7B affects PRPF8
1 |
PRPF8 binds LGALS7B. 1 / 1
1 |
biogrid
No evidence text available
28515276
LDHB affects PRPF8
1 |
PRPF8 binds LDHB. 1 / 1
1 |
biogrid
No evidence text available
28515276
LARP7 affects PRPF8
1 |
LARP7 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26725010
LAP affects SNRNP200
| 1
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
KRT8 affects PRPF8
1 |
PRPF8 binds KRT8. 1 / 1
1 |
biogrid
No evidence text available
28515276
KRT18 affects PRPF8
1 |
PRPF8 binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
28515276
KRT15 affects PRPF8
1 |
PRPF8 binds KRT15. 1 / 1
1 |
biogrid
No evidence text available
28515276
KIF23 affects PRPF8
1 |
KIF23 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31586073
IQGAP1 affects PRPF8
1 |
PRPF8 binds IQGAP1. 1 / 1
1 |
biogrid
No evidence text available
28515276
ILF2 affects PRPF8
1 |
PRPF8 binds ILF2. 1 / 1
1 |
biogrid
No evidence text available
28515276
IGLC3 affects PRPF8
1 |
PRPF8 binds IGLC3. 1 / 1
1 |
biogrid
No evidence text available
28515276
HSPA9 affects PRPF8
1 |
PRPF8 binds HSPA9. 1 / 1
1 |
biogrid
No evidence text available
28515276
HSPA6 affects PRPF8
1 |
PRPF8 binds HSPA6. 1 / 1
1 |
biogrid
No evidence text available
28515276
HSP90AB1 affects PRPF8
1 |
PRPF8 binds HSP90AB1. 1 / 1
1 |
biogrid
No evidence text available
28515276
HNRNPCL2 affects PRPF8
1 |
HNRNPCL2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33961781
HEXIM1 affects PRPF8
1 |
HEXIM1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
29845934
H2BC18 affects PRPF8
1 |
H2BC18 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30021884
H/ACA box snoRNAs affects PRPF8
| 1
H/ACA box snoRNAs binds PRPF8. 1 / 1
| 1
reach
"In addition, we found increased binding of PRPF8 to C/D and H/ACA box snoRNAs in RP13 retinal cells."
38605034
GstD1 affects PRPF8
| 1
GstD1 activates PRPF8. 1 / 1
| 1
reach
"Furthermore, gstD1-GFP and p53 upregulation was also observed in imaginal disc cells overexpressing the pathogenic RP13-linked mutant variant of Prp8 protein (Drosophila Prp8 /human PRPF8 ) (Supplementary Figure 1H–M), suggesting a shared response to U5 snRNP malfunction, inflicted either by scarcity of the biogenesis factor or mutation in the core splicing factor."
38303573
GTF2I affects PRPF8
1 |
PRPF8 binds GTF2I. 1 / 1
1 |
biogrid
No evidence text available
28515276
GOLGA4 affects PRPF8
1 |
PRPF8 binds GOLGA4. 1 / 1
1 |
biogrid
No evidence text available
28515276
GLS affects PRPF8
1 |
GLS binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30021884
GIGYF2 affects PRPF8
1 |
GIGYF2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
20696395
FZR1 affects PRPF8
1 |
FZR1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
33306668
FLG2 affects PRPF8
1 |
PRPF8 binds FLG2. 1 / 1
1 |
biogrid
No evidence text available
28515276
EZH2 affects PRPF8
1 |
EZH2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
36517590
ESR1 affects PRPF8
1 |
ESR1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26487511
ERCC6 affects PRPF8
1 |
ERCC6 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26030138
EPRS1 affects PRPF8
1 |
PRPF8 binds EPRS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
ELOC affects PRPF8
1 |
PRPF8 binds ELOC. 1 / 1
1 |
biogrid
No evidence text available
28515276
EIF4G1 affects docking protein-1
| 1
Docking protein-1 binds PRPF8 and EIF4G1. 1 / 1
| 1
sparser
"As a polymeric protein, pp62 protein is co-assembled with another polymeric protein, pp220, to form the inner core shell of ASFV ( xref )."
35097046
EIF3K affects PRPF8
1 |
PRPF8 binds EIF3K. 1 / 1
1 |
biogrid
No evidence text available
28515276
EIF2S3 affects PRPF8
1 |
PRPF8 binds EIF2S3. 1 / 1
1 |
biogrid
No evidence text available
28515276
EFTUD2 affects R2TP
| 1
R2TP binds PRPF8 and EFTUD2. 1 / 1
| 1
sparser
"Depletion of U5 proteins and PRPF8 RP mutation both increase the association of PRPF8 and EFTUD2 with R2TP."
28515276
EFTUD2 affects LAP, PRPF8, and SNRNP200
| 1
EFTUD2 binds SNRNP200, LAP, and PRPF8. 1 / 1
| 1
sparser
"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
EEF1A1P5 affects PRPF8
1 |
PRPF8 binds EEF1A1P5. 1 / 1
1 |
biogrid
No evidence text available
28515276
EBNA1BP2 affects PRPF8
1 |
PRPF8 binds EBNA1BP2. 1 / 1
1 |
biogrid
No evidence text available
28515276
E6 affects PRPF8
1 |
PRPF8 binds E6. 1 / 1
1 |
virhostnet
No evidence text available
22898364
Dietary Fats affects PRPF8
1 |
Dietary Fats increases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
19467301
DUSP2 affects PRPF8
1 |
DUSP2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
28675297
DPM1 affects PRPF8
1 |
PRPF8 binds DPM1. 1 / 1
1 |
biogrid
No evidence text available
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DNAJB4 affects PRPF8
1 |
PRPF8 binds DNAJB4. 1 / 1
1 |
biogrid
No evidence text available
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DHX30 affects PRPF8
1 |
PRPF8 binds DHX30. 1 / 1
1 |
biogrid
No evidence text available
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DENR affects PRPF8
| 1
PRPF8 binds DENR. 1 / 1
| 1
sparser
"Genes encoding proteins similar to NBS–LRR-type resistance proteins, such as r NBS41 , YR48 Nbs1-Pi9 , RGA3, RPP8 and DRP-RP13, were found in MQTL2.1, MQTL5.3, MQTL6.3, MQTL11.1, MQTL11.8 and MQTL11.9, respectively."
39013915
DDX50 affects DHX9, HNRNPC, PRPF8, SRPK1, SSRP1, and TOP2A
1 |
TOP2A binds SRPK1, PRPF8, DHX9, DDX50, SSRP1, and HNRNPC. 1 / 1
1 |
hprd
No evidence text available
15034300
DDX46 affects PRPF8
1 |
PRPF8 binds DDX46. 1 / 1
1 |
biogrid
No evidence text available
28515276
DARS1 affects PRPF8
1 |
PRPF8 binds DARS1. 1 / 1
1 |
biogrid
No evidence text available
28515276
Cebpb affects PRPF8
1 |
Cebpb binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30884312
Ccdc12 affects PRPF8
1 |
Ccdc12 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
26496610
CZF1 affects PRPF8
| 1
CZF1 activates PRPF8. 1 / 1
| 1
reach
"PRPF8, SNRNP200, GTPBP4, SMCHD1, DHX15, PRPF6, A8KAP3, DHX9 and EPRS were significantly reduced by RRM1 or ZnF1 deletion with no trend of> 2-fold for any other deletion mutant (Supplemental Table S4)."
29511296
CWC15 affects SNW1
| 1
SNW1 binds CWC15 and PRPF8. 1 / 1
| 1
sparser
"Finally, PPIG interacts with SNW1, CWC15, and PRPF8, all through the isomerase domain ( xref )."
30518120
CUL7 affects PRPF8
1 |
CUL7 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
24711643
CSTPP1 affects PRPF8
1 |
PRPF8 binds CSTPP1. 1 / 1
1 |
biogrid
No evidence text available
34079125
COPS2 affects PRPF8
1 |
COPS2 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
35831314
CHMP4B affects PRPF8
1 |
CHMP4B binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
31586073
CEBPB affects PRPF8
1 |
CEBPB binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
30884312
CAPRIN1 affects PRPF8
1 |
PRPF8 binds CAPRIN1. 1 / 1
1 |
biogrid
No evidence text available
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U2AF1 binds U2AF2, PTBP1, MRE11, TJP1, CAPRIN1, NUDT21, CPSF6, PRPF8, SFPQ, and PCF11. 1 / 1
1 |
hprd
No evidence text available
11060040
C9orf72 affects PRPF8
1 |
C9orf72 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
37317656
BRD4 affects PRPF8
1 |
BRD4 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32416067
BP affects PRPF8
| 1
PRPF8 binds BP. 1 / 1
| 1
reach
"It then facilitates the delocalization of Prp8, which was binding the 5′-SS and BP to make it bind both 5′-SS and 3′-SS, and it stabilizes this new conformation."
35885562
BAG3 affects PRPF8
1 |
PRPF8 binds BAG3. 1 / 1
1 |
biogrid
No evidence text available
28515276
ATP5F1B affects PRPF8
1 |
PRPF8 binds ATP5F1B. 1 / 1
1 |
biogrid
No evidence text available
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ATG5 affects PRPF8
1 |
ATG5 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
37054706
ASXL1 affects PRPF8
1 |
ASXL1 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
32683582
ALYREF affects PRPF8
1 |
PRPF8 binds ALYREF. 1 / 1
1 |
biogrid
No evidence text available
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ALDOA affects PRPF8
1 |
PRPF8 binds ALDOA. 1 / 1
1 |
biogrid
No evidence text available
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AHNAK affects PRPF8
1 |
PRPF8 binds AHNAK. 1 / 1
1 |
biogrid
No evidence text available
28515276
ACIN1 affects DDX21, DHX15, MATR3, PRPF8, S100A8, and SON
| 1
S100A8 binds ACIN1, DHX15, PRPF8, MATR3, DDX21, and SON. 1 / 1
| 1
sparser
"Calgranulin B was shown to interact directly with S100A8, ACIN1, DHX15, PRPF8, MATR3, DDX21, and SON (Figure xref )."
28036279
3-isobutyl-1-methyl-7H-xanthine decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
28628672
1,2-dimethylhydrazine increases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
22206623
3,4,3',4'-tetrachlorobiphenyl decreases the amount of PRPF8. 1 / 1
1 |
ctd
No evidence text available
19467301