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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PRPF8 inhibits ISPH. 2 / 2

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"Depletion of PRPF8 and treatment with a small molecule spliceosome inhibitor (PlaB) disrupts HDR, SSA, and end resection."

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"Using two independent siRNAs targeting PRPF8 (siPRPF8-2, siPRPF8-4), as well as a previously described siRNA targeting XAB2 (siXAB2-4), we found that PRPF8 and XAB2 depletion cause a significantly greater decrease in the frequency of HDR and SSA, compared to EJ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...