IndraLab

Statements

PRPF8 binds RBM22. 2 / 2
| 1 1
reach
"BEDtools also cannot show regions of unfavorable binding (the correlation is always positive) or differentiate between upstream and downstream binding geometries.The resolution limit of BEDtools is apparent when observing the binding of PRPF8, RBM22, U2AF2, and BUD13: PRPF8 and RBM22 appear to bind close to each other and U2AF2 and BUD13 bind close to each other as expected (Figures S8H and S8I); however, there is minimal difference in the correlation of U2AF2 with BUD13 versus U2AF2 with PRPF8 or RBM22 (Figure S8I), even though PRPF8 and RBM22 are known to generally bind further from U2AF2 than BUD13."
35474897
sparser
"This is in agreement with the association of PRPF8 and RBM22 with intron lariats as part of the human catalytic step I spliceosome xref ."
31570875