IndraLab

Statements

SART3 binds PRPF8. 11 / 11
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"Furthermore, miR-10b- U6 chimeras have been detected in the cross-linked and ligated SART3 and PRPF8 complexes, similar to the Ago complexes (Fig. xref b) indicative of the miR-10b interaction with U6 snRNP in the splicing complex."
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"Conversely, Ago2 and pan-Ago were immunoprecipitated in the SART3 and PRPF8 complexes (Supplementary Fig. xref b-e)."
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No evidence text available
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"We further demonstrate that miR-10b modulates U6 N-6-adenosine methylation and pseudouridylation, U6 binding to splicing factors SART3 and PRPF8, and regulates U6 stability, conformation, and levels."
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"At least two pieces of evidence provide support for the nuclear miR-10b maturation scenario: first, the finding of Ago2 and, more recently, of Dicer in the nucleus of specific cells, including glioma (Suppementary Fig. 5a) and [12, 56–58], and second, the co-IP of the spliceosomal SART3 and PRPF8 complexes with Ago2, the core endonucleolytic components of RISC that efficiently pools-down the entire miR-10b population from glioma cells."
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"At least two pieces of evidence provide support for the nuclear miR-10b maturation scenario: first, the finding of Ago2 and, more recently, of Dicer in the nucleus of specific cells, including glioma (Suppementary Fig. xref a) and [ xref , xref – xref ], and second, the co-IP of the spliceosomal SART3 and PRPF8 complexes with Ago2, the core endonucleolytic components of RISC that efficiently pools-down the entire miR-10b population from glioma cells."
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"These results indicate that miR-10b interferes with U6 incorporation into SART3 and PRPF8 snRNPs."
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"Both U6 and miR-10b have been significantly enriched in the spliceosomal SART3 and PRPF8 complexes (Fig. xref a and Supplementary Fig. xref a, b)."
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"Conversely, Ago2 and pan-Ago were immunoprecipitated in the SART3 and PRPF8 complexes (Supplementary Fig. 5b-e)."
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"Both U6 and miR-10b have been significantly enriched in the spliceosomal SART3 and PRPF8 complexes (Fig. 3a and Supplementary Fig. 4a, b)."
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"Furthermore, miR-10b- U6 chimeras have been detected in the cross-linked and ligated SART3 and PRPF8 complexes, similar to the Ago complexes (Fig. 3b) indicative of the miR-10b interaction with U6 snRNP in the splicing complex."
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