IndraLab

Statements

R2TP binds PRPF8. 4 / 4
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sparser
"PRPF8 also associates with R2TP mostly by the direct interaction with the RUVBL1–RUVBL2 complex, but the in vitro pull-down experiments and the mass spectrometry in cells suggest that RPAP3-PIH1D1 also contributes to bring PRPF8 to the R2TP complex."
34951455
sparser
"We then analyzed if PRPF8 could also interact with the other components of R2TP using the same methodology PRPF8 interacted directly with RPAP3-PIH1D1 in the presence and absence of RUVBL1–RUVBL2 (Figure xref , top panels, xref ) and this was confirmed when pulling down from GST-RPAP3 pull-down (Figure xref , bottom panels)."
34951455
sparser
"PRPF8 can interact with R2TP without the help of any additional factor, at least in vitro ."
34951455
sparser
"S2118F and H2309R mutations both increased the association of PRPF8 with R2TP ( xref ) and also with ZNHIT2 ( xref )."
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