IndraLab

"For correct determination of the IPSS-R score FISH for MECOM rearrangements should be included.OTHER RECURRENT FOCAL COPY NUMBER ABNORMALITIES IN MDSGenetic abnormalityNF1 loss RUNX1 loss RASSF1 loss CCND1 loss TET2 loss DNMT3A loss HRAS loss PDGFRA loss FIP1L1 loss ASXL1 loss ETV6 loss EZH2 loss KRAS loss NCOR2 loss NPM1 loss PRPF8 loss TP53 lossPrognostic impact not known locusReference17q11 21q22 3p21 11q13 4q24 2p23 11p15 4q12 4q12 20q11 12p13 7q36 12p12 12q24 5q35 17p13 17p13 (Kolquist et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011; Thiel et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011) (Kolquist et al., 2011) (Kolquist et al., 2011; Thiel et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011) (Kolquist et al., 2011; Haferlach et al., 2014) (Kolquist et al., 2011) (Kolquist et al., 2011) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) (Haferlach et al., 2014) Genes, Chromosomes & Cancer DOI 10.1002/gcc ARRAY GUIDELINES FOR HAEMATOLOGICAL NEOPLASIA489REFERENCESAffer M, Chesi M, Chen WD, Keats JJ, Demchenko YN, Tamizhmani K, Garbitt VM, Riggs DL, Brents LA, Roschke AV, Van Wier S, Fonseca R, Bergsagel PL, Kuehl WM. 2014."

"Strikingly, silencing of p53 rescues PRPF8 KD-induced apoptosis, indicating that PRPF8 KD triggers hESC apoptosis through activating the p53 pathway."