IndraLab

Statements

PRPF31 binds PRPF8. 11 / 11
5 | 6
reach
"The interaction of PRP31 or PRP3 and the U5 snRNP component PRP8 is reported to be regulated by the ubiquitination and deubiquitination status of PRP31 and PRP3, which is required for efficient RNA sp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31330151
biogrid
No evidence text available
28515276
biogrid
No evidence text available
35831314
biogrid
No evidence text available
28088760
reach
"In the spliceosome, ubiquitinated PRP3 and PRP31 bind PRP8 and stabilize the tri-snRNP complex [31] ."
30269981
reach
"These results indicated that PRP3 inhibits radioresistance at least in part due to promoting the production of FANCI‐12.2.6 PRP3 regulates FANCI alternative splicing by modulating the interaction between PRP31 and PRP8."
37168687
reach
"These observations indicated that PRP3 regulates FANCI alternative splicing by modulating the interaction between PRP31 and PRP8, the key components of complex B. Considering that PRP31 and PRP8 were downregulated in cells postradiation, these findings also demonstrate that PRP3 plays a functional role in the early step of cellular response to radiation.2.7 TXNL4B promotes radioresistance of lung cancer in vivo."
37168687
biogrid
No evidence text available
28515276
reach
"In addition, we found that PRP3 knockdown weakened the interaction of PRP31 and PRP8, which are key components for the assembly of U4/U6.U5 tri‐snRNP; this, in turn, led to FANCI exon skipping."
37168687
reach
"Mechanistically, PRP3 knockdown leads to the unstabilized U4/U6.U5 tri‐snRNP postradiation though affecting the physical interaction of PRP31 and PRP8."
37168687
biogrid
No evidence text available
26344197