IndraLab

Statements

PRPF8 binds EFTUD2. 37 / 37
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"The HSP90/R2TP machinery binds unassembled cytoplasmic forms of PRPF8 and EFTUD2."
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"To determine whether the interactions between R2TP and PRPF8 or EFTUD2 occur at an early cytoplasmic stage, we implemented a corecruitment assay using a fusion of RPAP3 with a fragment of p54, which targets the fusion protein to cytoplasmic P-bodies ( xref )."
28515276
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"To determine whether the interactions between R2TP and PRPF8 or EFTUD2 occur at an early cytoplasmic stage, we implemented a corecruitment assay using a fusion of RPAP3 with a fragment of p54, which targets the fusion protein to cytoplasmic P-bodies."
28515276
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28515276
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35271311
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35271311
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39358380
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"This indicated that EFTUD2 interacts with R2TP in the cytoplasm independently of PRPF8."
28515276
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25263594
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34079125
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"SNRNP200 is a large nuclear protein of 200 kDa, which interacts extensively with U5-specific proteins EFTUD2 (hSnu114) and Prpf8."
27302685
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"Collectively, our data confirm that interactions of the R2TP complex with PRPF8 and EFTUD2 occur early on in the cytoplasm and are independent of each other."
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"We also identified several U5 chaperones such as AAR2, ZNHIT2, RUVBL1, RUVBL2, and ECD and a putative chaperone EAPP that has been shown to interact with U5 proteins PRPF8 and EFTUD2 xref , xref , xref ."
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"In the nucleus, PRPF8 is forming a complex with EFTUD2 and SNRNP200 (also known as BRR2) as part of the spliceosome."
34951455
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"Yeast-2-hybrid experiments identified interactions between the U2-associated SF3b proteins and U5-specific proteins, especially hPrp8, hBrr2, and hSnu114 (Hegele et al. 2012)."
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40437099
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"PRPF8 also interacts with EFTUD2 and regulates SNRNP200 ATPase activity ( xref )."
40264708
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"These Prp8-RP mutants directly affect U5 snRNP and tri-snRNP maturation (Boon et al. 2007), Brr2 helicase, and ATPase activities (Pena et al. 2007; Maeder et al. 2009; Mozaffari-Jovin et al. 2013), and yeast-two-hybrid interactions between Brr2, Prp8, and Snu114 (Table 1; Pena et al. 2007)."
26968627
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17317632
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"Both domains make specific contacts with U5 subcomplexes where Hom3 primarily interacts with PRPF8 and EFTUD2 proteins that form a subcomplex early during biogenesis xref and Hom2 mediates interaction with the mature U5 particle."
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"An intermediate complex is formed with the recruitment of PRPF8 and EFTUD2 to the R2TP and HSP90 complex along with AAR2, ZNHIT2, and other assembly factors."
28884116
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26344197
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"EFTUD2 interacts with U5 RNA and spliceosomal proteins, including PRPF8, PRPF6, and SNRNP200, to form the U5 spliceosome complex. [ xref , xref ] PRPF8, a major structural protein, directly binds EFTUD2. [ xref , xref ] Co‐immunoprecipitation assays revealed significant binding deficits between PRPF8 and C476R or L637R mutants, whereas R262W and A823T maintained near‐WT interaction capacity (Figure xref , Supporting Information)."
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31839598
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35831314
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22939629
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9774689
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16723661
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39358380
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16723661
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9774689
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28515276
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"The proteomic analysis of the GFP IPs showed a strong association of PRPF8-LAP with its partners EFTUD2 and SNRNP200, and conversely, GFP-EFTUD2 strongly bound PRPF8 and SNRNP200."
28515276
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33961781