IndraLab

Statements

PRPF8 inhibits TP53. 2 / 2
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"Mechanistically, loss of function mutations in zebrafishPRPF8 have been shown to result in missplicing of TP53, 36 while PRPF8 knockdown in mammalian cells led to increased compensatory transcriptional activity of TP53, 39 suggesting another possibility of synergetic interaction between PRPF8 defects and TP53."
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reach
"PRPF8 knockdown (KD) induces p53 protein accumulation and activates the p53 pathway, leading to apoptosis in hESCs."
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